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According to some medical imaging techniques, breast histopathology images called Hematoxylin and Eosin are considered as the gold standard for cancer diagnoses. Based on the idea of dividing the pathologic image (WSI) into multiple…

Image and Video Processing · Electrical Eng. & Systems 2022-07-13 Tat-Bao-Thien Nguyen , Minh-Vuong Ngo , Van-Phong Nguyen

Accurate annotation of fixation type is a critical step in slide preparation for pathology laboratories. However, this manual process is prone to errors, impacting downstream analyses and diagnostic accuracy. Existing methods for verifying…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Oskar Thaeter , Tanja Niedermair , Jan E. G. Albin , Johannes Raffler , Ralf Huss , Peter J. Schüffler

Supervised deep learning methods have achieved considerable success in medical image analysis, owing to the availability of large-scale and well-annotated datasets. However, creating such datasets for whole slide images (WSIs) in…

Computer Vision and Pattern Recognition · Computer Science 2024-06-10 Hao Wang , Euijoon Ahn , Jinman Kim

To increase the objectivity and accuracy of pathologists' work, artificial neural network(ANN) methods have been generally needed in the segmentation, classification, and detection of histopathological WSI. In this paper, WSI analysis…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Xintong Li , Weiming Hu , Chen Li , Tao Jiang , Hongzan Sun , Xiaoyan Li , Xinyu Huang , Marcin Grzegorzek

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Patching gigapixel whole slide images (WSIs) is an important task in computational pathology. Some methods have been proposed to select a subset of patches as WSI representation for downstream tasks. While most of the computational…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Peyman Nejat , Areej Alsaafin , Ghazal Alabtah , Nneka Comfere , Aaron Mangold , Dennis Murphree , Patricija Zot , Saba Yasir , Joaquin J. Garcia , H. R. Tizhoosh

The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

Accurate diagnosis of disease often depends on the exhaustive examination of Whole Slide Images (WSI) at microscopic resolution. Efficient handling of these data-intensive images requires lossy compression techniques. This paper…

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Peihang Wu , Zehong Chen , Lijian Xu

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Jiawen Li , Qiehe Sun , Renao Yan , Yizhi Wang , Yuqiu Fu , Yani Wei , Tian Guan , Huijuan Shi , Yonghonghe He , Anjia Han

The integration of AI in digital pathology, particularly in whole slide image (WSI) and spatial transcriptomics (ST) analysis, holds immense potential for enhancing our understanding of diseases. Despite challenges such as training pattern…

Quantitative Methods · Quantitative Biology 2024-11-18 Chao-Hui Huang , Sara Lichtarge , Diane Fernandez

Transformer has been widely used in histopathology whole slide image (WSI) classification for the purpose of tumor grading, prognosis analysis, etc. However, the design of token-wise self-attention and positional embedding strategy in the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Yushan Zheng , Jun Li , Jun Shi , Fengying Xie , Zhiguo Jiang

This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Yanbo Feng , Adel Hafiane , Hélène Laurent

Survival analysis based on Whole Slide Images (WSIs) is crucial for evaluating cancer prognosis, as they offer detailed microscopic information essential for predicting patient outcomes. However, traditional WSI-based survival analysis…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Zheng Wang , Hong Liu , Zheng Wang , Danyi Li , Min Cen , Baptiste Magnier , Li Liang , Liansheng Wang

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-08 Hao Li , Ying Chen , Yifei Chen , Wenxian Yang , Bowen Ding , Yuchen Han , Liansheng Wang , Rongshan Yu

The histopathology analysis is of great significance for the diagnosis and prognosis of cancers, however, it has great challenges due to the enormous heterogeneity of gigapixel whole slide images (WSIs) and the intricate representation of…

Image and Video Processing · Electrical Eng. & Systems 2024-02-09 Mingxin Liu , Yunzan Liu , Pengbo Xu , Jiquan Ma

Due to the recent advancements in machine vision, digital pathology has gained significant attention. Histopathology images are distinctly rich in visual information. The tissue glass slide images are utilized for disease diagnosis.…

Image and Video Processing · Electrical Eng. & Systems 2020-11-02 Danial Maleki , Mehdi Afshari , Morteza Babaie , H. R. Tizhoosh

Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…

Computer Vision and Pattern Recognition · Computer Science 2022-07-13 Ming Feng , Kele Xu , Nanhui Wu , Weiquan Huang , Yan Bai , Changjian Wang , Huaimin Wang

This study introduces a new framework for the artificial intelligence-assisted characterization of Gram-stained whole-slide images (WSIs). As a test for the diagnosis of bloodstream infections, Gram stains provide critical early data to…

Image and Video Processing · Electrical Eng. & Systems 2024-09-30 Jack McMahon , Naofumi Tomita , Elizabeth S. Tatishev , Adrienne A. Workman , Cristina R Costales , Niaz Banaei , Isabella W. Martin , Saeed Hassanpour

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Cheng Jin , Luyang Luo , Huangjing Lin , Jun Hou , Hao Chen