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Computational pathology methods have the potential to improve access to precision medicine, as well as the reproducibility and accuracy of pathological diagnoses. Particularly the analysis of whole-slide-images (WSIs) of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Philippe Weitz , Viktoria Sartor , Balazs Acs , Stephanie Robertson , Daniel Budelmann , Johan Hartman , Mattias Rantalainen

Whole slide imaging is routinely adopted for carcinoma diagnosis and prognosis. Abundant experience is required for pathologists to achieve accurate and reliable diagnostic results of whole slide images (WSI). The huge size and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Pingyi Chen , Chenglu Zhu , Sunyi Zheng , Honglin Li , Lin Yang

Enhancing the robustness of deep learning models against adversarial attacks is crucial, especially in critical domains like healthcare where significant financial interests heighten the risk of such attacks. Whole slide images (WSIs) are…

Computer Vision and Pattern Recognition · Computer Science 2024-03-22 Saba Heidari Gheshlaghi , Milan Aryal , Nasim Yahyasoltani , Masoud Ganji

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Mycosis fungoides (MF) is a rare, potentially life threatening skin disease, which in early stages clinically and histologically strongly resembles Eczema, a very common and benign skin condition. In order to increase the survival rate, one…

Image and Video Processing · Electrical Eng. & Systems 2020-09-14 Jérémy Scheurer , Claudio Ferrari , Luis Berenguer Todo Bom , Michaela Beer , Werner Kempf , Luis Haug

Histopathological image analysis is the gold standard to diagnose cancer. Carcinoma is a subtype of cancer that constitutes more than 80% of all cancer cases. Squamous cell carcinoma and adenocarcinoma are two major subtypes of carcinoma,…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Swathi Prabhua , Keerthana Prasada , Antonio Robels-Kelly , Xuequan Lu

Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…

Image and Video Processing · Electrical Eng. & Systems 2023-02-23 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

The Segment Anything Model (SAM) marks a significant advancement in segmentation models, offering robust zero-shot abilities and dynamic prompting. However, existing medical SAMs are not suitable for the multi-scale nature of whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hong Liu , Haosen Yang , Paul J. van Diest , Josien P. W. Pluim , Mitko Veta

Histopathological images provide rich information for disease diagnosis. Large numbers of histopathological images have been digitized into high resolution whole slide images, opening opportunities in developing computational image analysis…

Image and Video Processing · Electrical Eng. & Systems 2020-11-06 Jiayun Li , Wenyuan Li , Anthony Sisk , Huihui Ye , W. Dean Wallace , William Speier , Corey W. Arnold

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

The last decade has seen significant advances in computer-aided diagnostics for cytological screening, mainly through the improvement and integration of scanning techniques such as whole slide imaging (WSI) and the combination with deep…

Signal Processing · Electrical Eng. & Systems 2026-01-23 Philip Groult , Julia D. Sistermanns , Ellen Emken , Oliver Hayden , Wolfgang Utschick

Specific and effective breast cancer therapy relies on the accurate quantification of PD-L1 positivity in tumors, which appears in the form of brown stainings in high resolution whole slide images (WSIs). However, the retrieval and…

Computational Engineering, Finance, and Science · Computer Science 2024-04-17 Giacomo Cignoni , Cristian Scatena , Chiara Frascarelli , Nicola Fusco , Antonio Giuseppe Naccarato , Giuseppe Nicoló Fanelli , Alina Sîrbu

Whole slide image (WSI) analysis in digital pathology presents unique challenges due to the gigapixel resolution of WSIs and the scarcity of dense supervision signals. While Multiple Instance Learning (MIL) is a natural fit for slide-level…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Sofiène Boutaj , Marin Scalbert , Pierre Marza , Florent Couzinie-Devy , Maria Vakalopoulou , Stergios Christodoulidis

High-fidelity registration of histopathological whole slide images (WSIs), such as hematoxylin & eosin (H&E) and immunohistochemistry (IHC), is vital for integrated molecular analysis but challenging to evaluate without ground-truth (GT)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Shikha Dubey , Patricia Raciti , Kristopher Standish , Albert Juan Ramon , Erik Ames Burlingame

Histological whole slide images (WSIs) can be usually compromised by artifacts, such as tissue folding and bubbles, which will increase the examination difficulty for both pathologists and Computer-Aided Diagnosis (CAD) systems. Existing…

Image and Video Processing · Electrical Eng. & Systems 2023-07-27 Zhenqi He , Junjun He , Jin Ye , Yiqing Shen

The expensive fine-grained annotation and data scarcity have become the primary obstacles for the widespread adoption of deep learning-based Whole Slide Images (WSI) classification algorithms in clinical practice. Unlike few-shot learning…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Kexue Fu , Xiaoyuan Luo , Linhao Qu , Shuo Wang , Ying Xiong , Ilias Maglogiannis , Longxiang Gao , Manning Wang

Presenting whole slide images (WSIs) as graph will enable a more efficient and accurate learning framework for cancer diagnosis. Due to the fact that a single WSI consists of billions of pixels and there is a lack of vast annotated datasets…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Milan Aryal , Nasim Yahyasoltani

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri

Whole Slide Images (WSIs) in histopathology pose a significant challenge for extensive medical image analysis due to their ultra-high resolution, massive scale, and intricate spatial relationships. Although existing Multiple Instance…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Jiaxuan Lu , Yuhui Lin , Junyan Shi , Fang Yan , Dongzhan Zhou , Yue Gao , Xiaosong Wang

Correct treatment of urothelial carcinoma patients is dependent on accurate grading and staging of the cancer tumour. This is determined manually by a pathologist by examining the histological whole-slide images (WSI). The large size of…

Image and Video Processing · Electrical Eng. & Systems 2019-09-12 Rune Wetteland , Kjersti Engan , Trygve Eftestøl , Vebjørn Kvikstad , Emilius A. M. Janssen