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The ubiquity and value of tables as semi-structured data across various domains necessitate advanced methods for understanding their complexity and vast amounts of information. Despite the impressive capabilities of large language models…

Computation and Language · Computer Science 2024-11-14 Deyi Ji , Lanyun Zhu , Siqi Gao , Peng Xu , Hongtao Lu , Jieping Ye , Feng Zhao

Tree-search-based reasoning methods have significantly enhanced the reasoning capability of large language models (LLMs) by facilitating the exploration of multiple intermediate reasoning steps, i.e., thoughts. However, these methods suffer…

Computation and Language · Computer Science 2025-05-27 Zhihai Wang , Jie Wang , Jilai Pan , Xilin Xia , Huiling Zhen , Mingxuan Yuan , Jianye Hao , Feng Wu

Large language models (LLMs) demonstrate impressive language understanding and contextual learning abilities, making them suitable for natural language processing (NLP) tasks and complex mathematical reasoning. However, when applied to…

Artificial Intelligence · Computer Science 2023-09-13 Haotian Xu

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful and widely used tools for molecular structure elucidation in organic chemistry. However, the interpretation of NMR spectra to determine unknown molecular structures…

Chemical Physics · Physics 2025-09-03 Yongqi Jin , Jun-Jie Wang , Fanjie Xu , Xiaohong Ji , Zhifeng Gao , Linfeng Zhang , Guolin Ke , Rong Zhu , Weinan E

Understanding complex biomolecular mechanisms requires multi-step reasoning across molecular interactions, signaling cascades, and metabolic pathways. While large language models(LLMs) show promise in such tasks, their application to…

Artificial Intelligence · Computer Science 2025-11-12 Tianwen Lyu , Xiang Zhuang , Keyan Ding , Xinzhe Cao , Lei Liang , Wei Zhao , Qiang Zhang , Huajun Chen

Molecular Property Prediction (MPP) is a fundamental problem in drug discovery that has recently attracted growing attention. Large Language Models (LLMs), known for their impressive proficiency across domains, show promise as generalist…

Machine Learning · Computer Science 2026-05-28 Khiem Le , Sreejata Dey , Marcos Martínez Galindo , Vanessa Lopez , Ting Hua , Nitesh V. Chawla , Hoang Thanh Lam

Large Language Models (LLMs) increasingly exhibit strong reasoning abilities, often attributed to their capacity to generate chain-of-thought-style intermediate reasoning. Recent work suggests that exposure to code can further enhance these…

Machine Learning · Computer Science 2026-01-30 Lukas Twist , Shu Yang , Hanqi Yan , Jingzhi Gong , Di Wang , Helen Yannakoudakis , Jie M. Zhang

Mathematical reasoning presents significant challenges for large language models (LLMs). To enhance their capabilities, we propose Monte Carlo Self-Refine Tree (MC-NEST), an extension of Monte Carlo Tree Search that integrates LLM-based…

Machine Learning · Computer Science 2025-06-03 Gollam Rabby , Farhana Keya , Sören Auer

Language models generate reasoning sequentially, preventing them from decoupling irrelevant exploration paths during search. We introduce Tree-Structured Language Modeling (TSLM), which uses special tokens to encode branching structure,…

Computation and Language · Computer Science 2026-02-02 Doyoung Kim , Jaehyeok Doo , Minjoon Seo

Effective query-item relevance modeling is pivotal for enhancing user experience and safeguarding user satisfaction in e-commerce search systems. Recently, benefiting from the vast inherent knowledge, Large Language Model (LLM) approach…

Information Retrieval · Computer Science 2025-02-11 Gang Zhao , Ximing Zhang , Chenji Lu , Hui Zhao , Tianshu Wu , Pengjie Wang , Jian Xu , Bo Zheng

In response to the lack of trust in Artificial Intelligence (AI) for sequential planning, we design a Computational Tree Logic-guided large language model (LLM)-based natural language explanation framework designed for the Monte Carlo Tree…

Artificial Intelligence · Computer Science 2025-05-02 Ziyan An , Xia Wang , Hendrik Baier , Zirong Chen , Abhishek Dubey , Taylor T. Johnson , Jonathan Sprinkle , Ayan Mukhopadhyay , Meiyi Ma

Existing large language models (LLMs) show exceptional problem-solving capabilities but might struggle with complex reasoning tasks. Despite the successes of chain-of-thought and tree-based search methods, they mainly depend on the internal…

Computation and Language · Computer Science 2024-12-18 Jinhao Jiang , Jiayi Chen , Junyi Li , Ruiyang Ren , Shijie Wang , Wayne Xin Zhao , Yang Song , Tao Zhang

We propose a method to create document representations that reflect their internal structure. We modify Tree-LSTMs to hierarchically merge basic elements such as words and sentences into blocks of increasing complexity. Our Structure…

Computation and Language · Computer Science 2019-10-08 Khalil Mrini , Claudiu Musat , Michael Baeriswyl , Martin Jaggi

A molecule's properties are fundamentally determined by its composition and structure encoded in its molecular graph. Thus, reasoning about molecular properties requires the ability to parse and understand the molecular graph. Large…

Machine Learning · Computer Science 2026-01-22 Christoph Bartmann , Johannes Schimunek , Mykyta Ielanskyi , Philipp Seidl , Günter Klambauer , Sohvi Luukkonen

Molecules are graphs, but large language models~(LLMs) are usually asked to reason about them through linear strings. The most popular molecular representation, SMILES, compresses atoms, bonds, branches and rings into a compact sequence in…

Biomolecules · Quantitative Biology 2026-05-19 Zhiyuan Yan , Chen Liu , Boxuan Zhao , Kaiqing Lin , Jixiang Zhao , Yimi Wang , Liuzhenghao Lv , Hao Li , Shanzhuo Zhang , Li Yuan , Fanyang Mo

How to edit the knowledge in multi-step reasoning has become the major challenge in the knowledge editing (KE) of large language models (LLMs). The difficulty arises because the hallucinations of LLMs during multi-step reasoning often lead…

Computation and Language · Computer Science 2024-11-12 Yiwei Wang , Muhao Chen , Nanyun Peng , Kai-Wei Chang

We introduce SELF-DISCOVER, a general framework for LLMs to self-discover the task-intrinsic reasoning structures to tackle complex reasoning problems that are challenging for typical prompting methods. Core to the framework is a…

Artificial Intelligence · Computer Science 2024-02-07 Pei Zhou , Jay Pujara , Xiang Ren , Xinyun Chen , Heng-Tze Cheng , Quoc V. Le , Ed H. Chi , Denny Zhou , Swaroop Mishra , Huaixiu Steven Zheng

Molecule generation and optimization is a fundamental task in chemical domain. The rapid development of intelligent tools, especially large language models (LLMs) with powerful knowledge reserves and interactive capabilities, has provided…

Machine Learning · Computer Science 2026-02-10 Haoran Liu , Zheni Zeng , Yukun Yan , Yuxuan Chen , Yunduo Xiao

Molecular optimization is a central task in drug discovery that requires precise structural reasoning and domain knowledge. While large language models (LLMs) have shown promise in generating high-level editing intentions in natural…

Machine Learning · Computer Science 2025-10-17 Wenyu Zhu , Chengzhu Li , Xiaohe Tian , Yifan Wang , Yinjun Jia , Jianhui Wang , Bowen Gao , Ya-Qin Zhang , Wei-Ying Ma , Yanyan Lan

Large language models (LLMs) have achieved remarkable multi-step reasoning capabilities across various domains. However, LLMs still face distinct challenges in complex logical reasoning, as (1) proof-finding requires systematic exploration…

Computation and Language · Computer Science 2025-09-16 Kang He , Kaushik Roy