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Early dementia diagnosis requires biomarkers sensitive to both structural and functional brain changes. While structural neuroimaging biomarkers have progressed significantly, objective functional biomarkers of early cognitive decline…

Neurons and Cognition · Quantitative Biology 2025-04-16 Tomasz M. Rutkowski , Stanisław Narębski , Mihoko Otake-Matsuura , Tomasz Komendziński

Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible…

Machine Learning · Computer Science 2019-05-02 Alex Fedorov , R Devon Hjelm , Anees Abrol , Zening Fu , Yuhui Du , Sergey Plis , Vince D. Calhoun

Background: Artificial intelligence (AI) models in healthcare depend on the fidelity of diagnostic data, yet the quality of such data is often compromised by variability in clinical documentation practices. In dementia, a condition already…

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's…

Health sensing for chronic disease management creates immense benefits for social welfare. Existing health sensing studies primarily focus on the prediction of physical chronic diseases. Depression, a widespread complication of chronic…

Artificial Intelligence · Computer Science 2025-04-17 Jiaheng Xie , Xiaohang Zhao , Xiang Liu , Xiao Fang

Relatively abundant availability of medical imaging data has provided significant support in the development and testing of Neural Network based image processing methods. Clinicians often face issues in selecting suitable image processing…

Image and Video Processing · Electrical Eng. & Systems 2021-09-10 Mayank Goswami

Dementia, a prevalent neurodegenerative condition, is a major manifestation of Alzheimer's disease (AD). As the condition progresses from mild to severe, it significantly impairs the individual's ability to perform daily tasks…

Machine Learning · Computer Science 2023-11-06 Md Gulzar Hussain , Ye Shiren

Mild cognitive impairment (MCI) leading to dementia results in a constellation of psychiatric disorders including depression, mood disorders, schizophrenia and others. With increasing age, mild cognitive impairment leads to increased…

Neurons and Cognition · Quantitative Biology 2023-08-10 Sheng Mai

Exploring the application of deep learning technologies in the field of medical diagnostics, Magnetic Resonance Imaging (MRI) provides a unique perspective for observing and diagnosing complex neurodegenerative diseases such as Alzheimer…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Shaojie Li , Haichen Qu , Xinqi Dong , Bo Dang , Hengyi Zang , Yulu Gong

Dementia, a progressive neurodegenerative disorder, affects memory, reasoning, and daily functioning, creating challenges for individuals and healthcare systems. Early detection is crucial for timely interventions that may slow disease…

Neurons and Cognition · Quantitative Biology 2025-03-04 Sahar Sinene Mehdoui , Abdelhamid Bouzid , Daniel Sierra-Sosa , Adel Elmaghraby

People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This paper is…

Methodology · Statistics 2018-08-07 Jonathan P Williams , Curtis B Storlie , Terry M Therneau , Clifford R Jack , Jan Hannig

Dementia, a debilitating neurological condition affecting millions worldwide, presents significant diagnostic challenges. In this work, we introduce DEFORMISE, a novel DEep learning Framework for dementia diagnOsis of eldeRly patients using…

Image and Video Processing · Electrical Eng. & Systems 2025-11-21 Nikolaos Ntampakis , Konstantinos Diamantaras , Ioanna Chouvarda , Vasileios Argyriou , Panagiotis Sarigianndis

Early diagnosis of Alzheimer's Disease (AD) is very important for following medical treatments, and eye movements under special visual stimuli may serve as a potential non-invasive biomarker for detecting cognitive abnormalities of AD…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Yu Liu , Wenlin Zhang , Shaochu Wang , Fangyu Zuo , Peiguang Jing , Yong Ji

Early detection of dementia is critical for timely medical intervention and improved patient outcomes. Neuropsychological tests are widely used for cognitive assessment but have traditionally relied on manual scoring. Automatic dementia…

Machine Learning · Computer Science 2025-07-15 Liming Wang , Saurabhchand Bhati , Cody Karjadi , Rhoda Au , James Glass

Hyperkinetic movement disorders (HMDs) in children, including dystonia (abnormal twisting) and chorea (irregular, random movements), pose significant diagnostic challenges due to overlapping clinical features. The prevalence of dystonia…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Nandika Ramamurthy , Dr Daniel Lumsden , Dr Rachel Sparks

Deep neural networks currently provide the most advanced and accurate machine learning models to distinguish between structural MRI scans of subjects with Alzheimer's disease and healthy controls. Unfortunately, the subtle brain alterations…

Image and Video Processing · Electrical Eng. & Systems 2022-07-26 Di Wang , Nicolas Honnorat , Peter T. Fox , Kerstin Ritter , Simon B. Eickhoff , Sudha Seshadri , Mohamad Habes

Alzheimer's disease is a progressive neurodegenerative disorder that gradually deprives the patient of cognitive function and can end in death. With the advancement of technology today, it is possible to detect Alzheimer's disease through…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Muhammad Wildan Oktavian , Novanto Yudistira , Achmad Ridok

Mild cognitive impairment (MCI) is a high-risk dementia condition which progresses to probable Alzheimer's disease (AD) at approximately 10% to 15% per year. Characterization of group-level differences between two subtypes of MCI - stable…

Neurons and Cognition · Quantitative Biology 2021-06-15 Lu Zhang , Xiaowei Yu , Yanjun Lyu , Li Wang , Dajiang Zhu

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative

Mild Cognitive Impairment (MCI) is an early stage of Alzheimer's disease (AD), a form of neurodegenerative disorder. Early identification of MCI is crucial for delaying its progression through timely interventions. Existing research has…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-18 Kristin Qi , Jiatong Shi , Caroline Summerour , John A. Batsis , Xiaohui Liang