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The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing…

Quantitative Methods · Quantitative Biology 2024-09-10 Yizhen Zheng , Huan Yee Koh , Maddie Yang , Li Li , Lauren T. May , Geoffrey I. Webb , Shirui Pan , George Church

Large Language Models (LLMs) have emerged as powerful tools in various research domains. This article examines their potential through a literature review and firsthand experimentation. While LLMs offer benefits like cost-effectiveness and…

Human-Computer Interaction · Computer Science 2024-04-10 M. Namvarpour , A. Razi

The rapid development of large language models (LLMs) has significantly transformed the field of artificial intelligence, demonstrating remarkable capabilities in natural language processing and moving towards multi-modal functionality.…

Large Language Models (LLMs) have introduced a paradigm shift in interaction with AI technology, enabling knowledge workers to complete tasks by specifying their desired outcome in natural language. LLMs have the potential to increase…

Human-Computer Interaction · Computer Science 2025-03-24 Michelle Brachman , Amina El-Ashry , Casey Dugan , Werner Geyer

The advancement of generative AI, particularly large language models (LLMs), has a significant impact on politics and democracy, offering potential across various domains, including policymaking, political communication, analysis, and…

Computation and Language · Computer Science 2024-12-17 Goshi Aoki

The rapid advancement of Large Language Models (LLMs), reasoning models, and agentic AI approaches coincides with a growing global mental health crisis, where increasing demand has not translated into adequate access to professional…

Human-Computer Interaction · Computer Science 2025-04-03 Kellie Yu Hui Sim , Kenny Tsu Wei Choo

The rapid advancements in large language models (LLMs) have opened up new opportunities for transforming patient engagement in healthcare through conversational AI. This paper presents an overview of the current landscape of LLMs in…

Artificial Intelligence · Computer Science 2024-11-27 Bo Wen , Raquel Norel , Julia Liu , Thaddeus Stappenbeck , Farhana Zulkernine , Huamin Chen

Large Language Models (LLMs) excel in handling general knowledge tasks, yet they struggle with user-specific personalization, such as understanding individual emotions, writing styles, and preferences. Personalized Large Language Models…

Artificial Intelligence · Computer Science 2025-09-23 Jiahong Liu , Zexuan Qiu , Zhongyang Li , Quanyu Dai , Wenhao Yu , Jieming Zhu , Minda Hu , Menglin Yang , Tat-Seng Chua , Irwin King

Large Language Models (LLMs) have emerged as transformative tools in artificial intelligence (AI), exhibiting remarkable capabilities across diverse tasks such as text generation, reasoning, and decision-making. While their success has…

The use of large language models (LLMs) in qualitative analysis offers enhanced efficiency but raises questions about their alignment with the contextual nature of research for design (RfD). This research examines the trustworthiness of…

Human-Computer Interaction · Computer Science 2025-04-24 Joel Oksanen , Andrés Lucero , Perttu Hämäläinen

Large Language Models (LLMs) hold the potential to perform a variety of text processing tasks and provide textual explanations for proposed actions or decisions. In the era of hybrid work, LLMs can provide intelligent decision support for…

Computation and Language · Computer Science 2024-02-07 Yujin Kim , Chin-Chia Hsu

Large Language Models (LLMs) have seen rapid advancements in recent years, with models like ChatGPT and DeepSeek, showcasing their remarkable capabilities across diverse domains. While substantial research has been conducted on LLMs in…

Machine Learning · Computer Science 2026-03-31 Licheng Zhang , Bach Le , Naveed Akhtar , Siew-Kei Lam , Tuan Ngo

This paper studies the performance of large language models (LLMs), particularly regarding demographic fairness, in solving real-world healthcare tasks. We evaluate state-of-the-art LLMs with three prevalent learning frameworks across six…

Computation and Language · Computer Science 2024-12-10 Yue Zhou , Barbara Di Eugenio , Lu Cheng

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Recent advances in artificial intelligence, particularly large language models LLMs, have shown promising capabilities in transforming rare disease research. This survey paper explores the integration of LLMs in the analysis of rare…

Computation and Language · Computer Science 2025-05-26 Valentina Carbonari , Pierangelo Veltri , Pietro Hiram Guzzi

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains…

Artificial Intelligence · Computer Science 2024-08-22 Yining Hua , Hongbin Na , Zehan Li , Fenglin Liu , Xiao Fang , David Clifton , John Torous

While large language models (LLMs) present significant potential for supporting numerous real-world applications and delivering positive social impacts, they still face significant challenges in terms of the inherent risk of privacy…

Artificial Intelligence · Computer Science 2025-01-17 Huandong Wang , Wenjie Fu , Yingzhou Tang , Zhilong Chen , Yuxi Huang , Jinghua Piao , Chen Gao , Fengli Xu , Tao Jiang , Yong Li

Design studies aim to create visualization solutions for real-world problems of different application domains. Recently, the emergence of large language models (LLMs) has introduced new opportunities to enhance the design study process,…

Human-Computer Interaction · Computer Science 2025-08-14 Shaolun Ruan , Rui Sheng , Xiaolin Wen , Jiachen Wang , Tianyi Zhang , Yong Wang , Tim Dwyer , Jiannan Li

Large Language Models (LLMs) have demonstrated remarkable language understanding and generation capabilities. However, training, deploying, and accessing these models pose notable challenges, including resource-intensive demands, extended…

Computation and Language · Computer Science 2024-01-31 Souvika Sarkar , Mohammad Fakhruddin Babar , Monowar Hasan , Shubhra Kanti Karmaker

The application of large language models (LLMs) in healthcare has gained significant attention due to their ability to process complex medical data and provide insights for clinical decision-making. These models have demonstrated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Amna Khalid , Ayma Khalid , Umar Khalid