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Diffusion MRI (dMRI) is the primary imaging modality used to study brain microstructure in vivo. Reliable and computationally efficient parameter inference for common dMRI biophysical models is a challenging inverse problem, due to factors…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 William Consagra , Lipeng Ning , Yogesh Rathi

Diffusion magnetic resonance imaging is an imaging technology designed to probe anatomical architectures of biological samples in an in vivo and non-invasive manner through measuring water diffusion. The contribution of this paper is…

Diffusion-weighted (DW) MRI measures the direction and scale of the local diffusion process in every voxel through its spectrum in q-space, typically acquired in one or more shells. Recent developments in micro-structure imaging and…

We develop a general analytical and numerical framework for estimating intra- and extra-neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion, in each imaging voxel. By employing a set of rotational…

Biological Physics · Physics 2018-04-10 Dmitry S. Novikov , Jelle Veraart , Ileana O. Jelescu , Els Fieremans

Diffusion-weighted magnetic resonance imaging allows for reconstruction of models for structural connectivity in the brain, such as fiber orientation distribution functions (ODFs) that describe the distribution, direction, and volume of…

We introduce and demonstrate a new paradigm for quantitative parameter mapping in MRI. Parameter mapping techniques, such as diffusion MRI and quantitative MRI, have the potential to robustly and repeatably measure biologically-relevant…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Moucheng Xu , Yukun Zhou , Tobias Goodwin-Allcock , Kimia Firoozabadi , Joseph Jacob , Daniel C. Alexander , Paddy J. Slator

Diffusion Tensor Imaging (DTI) is a non-invasive imaging technique that allows estimation of the location of white matter tracts in-vivo, based on the measurement of water diffusion properties. For each voxel, a second-order tensor can be…

Computer Vision and Pattern Recognition · Computer Science 2013-10-24 Miriam H. A. Bauer , Sebastiano Barbieri , Jan Klein , Jan Egger , Daniela Kuhnt , Bernd Freisleben , Horst K. Hahn , Christopher Nimsky

High spatio-angular resolution diffusion MRI (dMRI) has been shown to provide accurate identification of complex neuronal fiber configurations, albeit, at the cost of long acquisition times. We propose a method to recover intra-voxel fiber…

Image and Video Processing · Electrical Eng. & Systems 2021-12-07 Marica Pesce , Audrey Repetti , Anna Auría , Alessandro Daducci , Jean-Philippe Thiran , Yves Wiaux

Models of diffusion MRI within a voxel are useful for making inferences about the properties of the tissue and inferring fiber orientation distribution used by tractography algorithms. A useful model must fit the data accurately. However,…

Quantitative Methods · Quantitative Biology 2017-02-08 Ariel Rokem , Jason D. Yeatman , Franco Pestilli , Kendrick N. Kay , Aviv Mezer , Stefan van der Walt , Brian A. Wandell

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…

Diffusion Magnetic Resonance Imaging (dMRI) plays a critical role in studying microstructural changes in the brain. It is, therefore, widely used in clinical practice; yet progress in learning general-purpose representations from dMRI has…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Gustavo Chau Loo Kung , Mohammad Abbasi , Camila Blank , Juze Zhang , Alan Q. Wang , Sophie Ostmeier , Akshay Chaudhari , Kilian Pohl , Ehsan Adeli

Purpose: To assess the technical feasibility of whole-brain diffusional variance decomposition (DIVIDE) based on q-space trajectory encoding (QTE) at clinical MRI systems with varying performance. DIVIDE is used to separate diffusional…

Medical Physics · Physics 2019-04-03 Filip Szczepankiewicz , Jens Sjölund , Freddy Ståhlberg , Jimmy Lätt , Markus Nilsson

We present a rotation-equivariant unsupervised learning framework for the sparse deconvolution of non-negative scalar fields defined on the unit sphere. Spherical signals with multiple peaks naturally arise in Diffusion MRI (dMRI), where…

Image and Video Processing · Electrical Eng. & Systems 2021-02-19 Axel Elaldi , Neel Dey , Heejong Kim , Guido Gerig

Diffusion-weighted imaging (DWI) is a type of Magnetic Resonance Imaging (MRI) technique sensitised to the diffusivity of water molecules, offering the capability to inspect tissue microstructures and is the only in-vivo method to…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Sheng Chen , Zihao Tang , Mariano Cabezas , Xinyi Wang , Arkiev D'Souza , Michael Barnett , Fernando Calamante , Weidong Cai , Chenyu Wang

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter, we designed an optimal diffusion-relaxometry MRI protocol…

Deep learning approaches for diffusion MRI have so far focused primarily on voxel-based segmentation of lesions or white-matter fiber tracts. A drawback of representing tracts as volumetric labels, rather than sets of streamlines, is that…

Image and Video Processing · Electrical Eng. & Systems 2020-09-10 Christian Ewert , David Kügler , Anastasia Yendiki , Martin Reuter

Accurate segmentation of brain tumors in MRI scans is essential for reliable clinical diagnosis and effective treatment planning. Recently, diffusion models have demonstrated remarkable effectiveness in image generation and segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-07-31 Sara Yavari , Rahul Nitin Pandya , Jacob Furst

Fiber tractography is an important tool of computational neuroscience that enables reconstructing the spatial connectivity and organization of white matter of the brain. Fiber tractography takes advantage of diffusion Magnetic Resonance…

Image and Video Processing · Electrical Eng. & Systems 2020-09-08 Tomer Weiss , Sanketh Vedula , Ortal Senouf , Oleg Michailovich , AlexBronstein

This article introduces a new methodology for reconstructing the white matter fiber pathways of brain in diffusion MRI. Usually, the signal intensity values will be lesser in the direction of higher diffusivity. The proposed approach picks…

Neurons and Cognition · Quantitative Biology 2022-07-26 Ashishi Puri , Sanjeev Kumar

Purpose: Stimulated echo acquisition mode (STEAM) diffusion MRI can be advantageous over pulsed-gradient spin-echo (PGSE) for diffusion times that are long compared to $\ttwo$. It is important therefore for biomedical diffusion imaging…

Medical Physics · Physics 2013-06-13 Daniel C. Alexander , Tim B. Dyrby
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