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Melanoma is amongst most aggressive types of cancer. However, it is highly curable if detected in its early stages. Prescreening of suspicious moles and lesions for malignancy is of great importance. Detection can be done by images captured…

Computer Vision and Pattern Recognition · Computer Science 2017-03-29 Mohammad H. Jafari , Ebrahim Nasr-Esfahani , Nader Karimi , S. M. Reza Soroushmehr , Shadrokh Samavi , Kayvan Najarian

Pathological brain appearances may be so heterogeneous as to be intelligible only as anomalies, defined by their deviation from normality rather than any specific pathological characteristic. Amongst the hardest tasks in medical imaging,…

Image and Video Processing · Electrical Eng. & Systems 2021-02-24 Walter Hugo Lopez Pinaya , Petru-Daniel Tudosiu , Robert Gray , Geraint Rees , Parashkev Nachev , Sebastien Ourselin , M. Jorge Cardoso

Artificial intelligence is increasingly integrated into radiotherapy workflows, yet such pipelines remain vulnerable to out-of-distribution image data that may introduce unexpected behavior in clinical tasks. Deep learning-based anomaly…

Unsupervised anomaly detection in brain images is crucial for identifying injuries and pathologies without access to labels. However, the accurate localization of anomalies in medical images remains challenging due to the inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-07-25 Farzad Beizaee , Gregory Lodygensky , Christian Desrosiers , Jose Dolz

Medical imaging data suffers from the limited availability of annotation because annotating 3D medical data is a time-consuming and expensive task. Moreover, even if the annotation is available, supervised learning-based approaches suffer…

Image and Video Processing · Electrical Eng. & Systems 2020-11-12 Abinav Ravi Venkatakrishnan , Seong Tae Kim , Rami Eisawy , Franz Pfister , Nassir Navab

Unsupervised anomaly detection (UAD) presents a complementary alternative to supervised learning for brain tumor segmentation in magnetic resonance imaging (MRI), particularly when annotated datasets are limited, costly, or inconsistent. In…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Gerard Comas-Quiles , Carles Garcia-Cabrera , Julia Dietlmeier , Noel E. O'Connor , Ferran Marques

Neural network-based anomaly detection remains challenging in clinical applications with little or no supervised information and subtle anomalies such as hardly visible brain lesions. Among unsupervised methods, patch-based auto-encoders…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Nicolas Pinon , Geoffroy Oudoumanessah , Robin Trombetta , Michel Dojat , Florence Forbes , Carole Lartizien

Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

Deep learning has become the mainstream methodological choice for analyzing and interpreting whole-slide digital pathology images (WSIs). It is commonly assumed that tumor regions carry most predictive information. In this paper, we…

Quantitative Methods · Quantitative Biology 2022-04-26 Zihan Chen , Xingyu Li , Miaomiao Yang , Hong Zhang , Xu Steven Xu

Image anomaly detection consists in detecting images or image portions that are visually different from the majority of the samples in a dataset. The task is of practical importance for various real-life applications like biomedical image…

Computer Vision and Pattern Recognition · Computer Science 2022-10-28 Axel De Nardin , Pankaj Mishra , Gian Luca Foresti , Claudio Piciarelli

Anomaly detection for Magnetic Resonance Images (MRIs) can be solved with unsupervised methods by learning the distribution of healthy images and identifying anomalies as outliers. In presence of an additional dataset of unlabelled data…

Machine Learning · Computer Science 2020-07-27 Alexandra-Ioana Albu , Alina Enescu , Luigi Malagò

We present a method to segment MRI scans of the human brain into ischemic stroke lesion and normal tissues. We propose a neural network architecture in the form of a standard encoder-decoder where predictions are guided by a spatial…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Alex Wong , Allison Chen , Yangchao Wu , Safa Cicek , Alexandre Tiard , Byung-Woo Hong , Stefano Soatto

Brain tissue segmentation from multimodal MRI is a key building block of many neuroimaging analysis pipelines. Established tissue segmentation approaches have, however, not been developed to cope with large anatomical changes resulting from…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Reuben Dorent , Thomas Booth , Wenqi Li , Carole H. Sudre , Sina Kafiabadi , Jorge Cardoso , Sebastien Ourselin , Tom Vercauteren

Local discriminative representation is needed in many medical image analysis tasks such as identifying sub-types of lesion or segmenting detailed components of anatomical structures. However, the commonly applied supervised representation…

Computer Vision and Pattern Recognition · Computer Science 2021-03-25 Huai Chen , Jieyu Li , Renzhen Wang , Yijie Huang , Fanrui Meng , Deyu Meng , Qing Peng , Lisheng Wang

Finding automatically multiple lesions in large images is a common problem in medical image analysis. Solving this problem can be challenging if, during optimization, the automated method cannot access information about the location of the…

Computer Vision and Pattern Recognition · Computer Science 2020-03-23 Florian Dubost , Hieab Adams , Pinar Yilmaz , Gerda Bortsova , Gijs van Tulder , M. Arfan Ikram , Wiro Niessen , Meike Vernooij , Marleen de Bruijne

We introduce "PatchMorph," an new stochastic deep learning algorithm tailored for unsupervised 3D brain image registration. Unlike other methods, our method uses compact patches of a constant small size to derive solutions that can combine…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Henrik Skibbe , Michal Byra , Akiya Watakabe , Tetsuo Yamamori , Marco Reisert

Brain pathologies can vary greatly in size and shape, ranging from few pixels (i.e. MS lesions) to large, space-occupying tumors. Recently proposed Autoencoder-based methods for unsupervised anomaly segmentation in brain MRI have shown…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Christoph Baur , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

Brain tumors are one of the deadliest forms of cancer with a mortality rate of over 80%. A quick and accurate diagnosis is crucial to increase the chance of survival. However, in medical analysis, the manual annotation and segmentation of a…

Image and Video Processing · Electrical Eng. & Systems 2024-03-18 Zachary Schwehr , Sriman Achanta

Brain tissue segmentation from multimodal MRI is a key building block of many neuroscience analysis pipelines. It could also play an important role in many clinical imaging scenarios. Established tissue segmentation approaches have however…

Image and Video Processing · Electrical Eng. & Systems 2020-04-15 Reuben Dorent , Wenqi Li , Jinendra Ekanayake , Sebastien Ourselin , Tom Vercauteren

Anomaly detection (AD) is the identification of data samples that do not fit a learned data distribution. As such, AD systems can help physicians to determine the presence, severity, and extension of a pathology. Deep generative models,…

Image and Video Processing · Electrical Eng. & Systems 2021-04-12 Jaime Simarro , Ezequiel de la Rosa , Thijs Vande Vyvere , David Robben , Diana M. Sima