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Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

Computation and Language · Computer Science 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

Generative pre-trained transformer (GPT) models have shown promise in clinical entity and relation extraction tasks because of their precise extraction and contextual understanding capability. In this work, we further leverage the Unified…

Computation and Language · Computer Science 2024-07-16 Kriti Bhattarai , Inez Y. Oh , Zachary B. Abrams , Albert M. Lai

Recent advances in Large Language Models (LLMs) have led to remarkable progresses in medical consultation. However, existing medical LLMs overlook the essential role of Electronic Health Records (EHR) and focus primarily on diagnosis…

Artificial Intelligence · Computer Science 2025-06-26 Weijieying Ren , Tianxiang Zhao , Lei Wang , Tianchun Wang , Vasant Honavar

The causal relationships between biomarkers are essential for disease diagnosis and medical treatment planning. One notable application is Alzheimer's disease (AD) diagnosis, where certain biomarkers may influence the presence of others,…

Information Retrieval · Computer Science 2025-06-13 Xiaofan Zhou , Liangjie Huang , Pinyang Cheng , Wenpen Yin , Rui Zhang , Wenrui Hao , Lu Cheng

Retrieval-augmented generation (RAG) improves large language model reliability by grounding generated responses in external evidence. However, RAG performance depends on the relevance of retrieved passages, the quality of evidence ranking,…

Information Retrieval · Computer Science 2026-05-05 Fariba Afrin Irany , Sampson Akwafuo

In this paper, we investigate the retrieval-augmented generation (RAG) based on Knowledge Graphs (KGs) to improve the accuracy and reliability of Large Language Models (LLMs). Recent approaches suffer from insufficient and repetitive…

Computation and Language · Computer Science 2024-04-22 Xinke Jiang , Ruizhe Zhang , Yongxin Xu , Rihong Qiu , Yue Fang , Zhiyuan Wang , Jinyi Tang , Hongxin Ding , Xu Chu , Junfeng Zhao , Yasha Wang

Incentivizing the reasoning ability of Multimodal Large Language Models (MLLMs) is essential for medical applications to transparently analyze medical scans and provide reliable diagnosis. However, existing medical MLLMs rely solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Lehan Wang , Yi Qin , Honglong Yang , Xiaomeng Li

Patients have long sought health information online, and increasingly, they are turning to generative AI to answer their health-related queries. Given the high stakes of the medical domain, techniques like retrieval-augmented generation and…

Computation and Language · Computer Science 2025-06-11 Lionel Wong , Ayman Ali , Raymond Xiong , Shannon Zeijang Shen , Yoon Kim , Monica Agrawal

Medical retrieval-augmented generation (RAG) systems typically operate on text chunks extracted from biomedical literature, discarding the rich visual content (tables, figures, structured layouts) of original document pages. We propose…

Artificial Intelligence · Computer Science 2026-05-01 Xupeng Chen , Binbin Shi , Chenqian Le , Jiaqi Zhang , Kewen Wang , Ran Gong , Jinhan Zhang , Chihang Wang

Large Language Models (LLMs) struggle with generating reliable outputs due to outdated knowledge and hallucinations. Retrieval-Augmented Generation (RAG) models address this by enhancing LLMs with external knowledge, but often fail to…

Information Retrieval · Computer Science 2026-01-16 Saber Zerhoudi , Michael Granitzer

Evidence-based medicine (EBM) holds a crucial role in clinical application. Given suitable medical articles, doctors effectively reduce the incidence of misdiagnoses. Researchers find it efficient to use large language models (LLMs)…

Computation and Language · Computer Science 2025-11-07 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bing Qin

Conventional Retrieval Augmented Generation (RAG) approaches are common in text-based applications. However, they struggle with structured, interconnected datasets like knowledge graphs, where understanding underlying relationships is…

Information Retrieval · Computer Science 2025-07-15 Savini Kashmira , Jayanaka L. Dantanarayana , Krisztián Flautner , Lingjia Tang , Jason Mars

Retrieval-augmented generation (RAG) has emerged as a promising solution for mitigating hallucinations of large language models (LLMs) with retrieved external knowledge. Adaptive RAG enhances this approach by enabling dynamic retrieval…

Computation and Language · Computer Science 2024-10-07 Huanshuo Liu , Hao Zhang , Zhijiang Guo , Jing Wang , Kuicai Dong , Xiangyang Li , Yi Quan Lee , Cong Zhang , Yong Liu

Retrieval-augmented generation (RAG) is a paradigm that augments large language models (LLMs) with external knowledge to tackle knowledge-intensive question answering. While several benchmarks evaluate Multimodal LLMs (MLLMs) under…

Computation and Language · Computer Science 2025-08-18 Yin Wu , Quanyu Long , Jing Li , Jianfei Yu , Wenya Wang

Large Language Models (LLMs) have achieved impressive progress in natural language processing, but their limited ability to retain long-term context constrains performance on document-level or multi-turn tasks. Retrieval-Augmented…

Computation and Language · Computer Science 2025-05-20 Zhangyu Wang , Siyuan Gao , Rong Zhou , Hao Wang , Li Ning

Access to the right evidence does not guarantee that large language models (LLMs) will reason with it correctly. This gap between retrieval and reasoning is especially concerning in clinical settings, where outputs must align with…

Artificial Intelligence · Computer Science 2025-11-21 Deepthi Potluri , Aby Mammen Mathew , Jeffrey B DeWitt , Alexander L. Rasgon , Yide Hao , Junyuan Hong , Ying Ding

Retrieval-Augmented Generation (RAG) was introduced to enhance the capabilities of Large Language Models (LLMs) beyond their encoded prior knowledge. This is achieved by providing LLMs with an external source of knowledge, which helps…

Computation and Language · Computer Science 2026-03-11 Hazem Amamou , Stéphane Gagnon , Alan Davoust , Anderson R. Avila

Retrieval-Augmented Generation (RAG) offers a cost-effective approach to injecting real-time knowledge into large language models (LLMs). Nevertheless, constructing and validating high-quality knowledge repositories require considerable…

Computation and Language · Computer Science 2024-05-28 Xun Liang , Simin Niu , Zhiyu li , Sensen Zhang , Shichao Song , Hanyu Wang , Jiawei Yang , Feiyu Xiong , Bo Tang , Chenyang Xi

Recent surge in the accessibility of large language models (LLMs) to the general population can lead to untrackable use of such models for medical-related recommendations. Language generation via LLMs models has two key problems: firstly,…

Computation and Language · Computer Science 2024-07-24 Ioana Buhnila , Aman Sinha , Mathieu Constant

Retrieval-augmented generation (RAG) frameworks enable large language models (LLMs) to retrieve relevant information from a knowledge base and incorporate it into the context for generating responses. This mitigates hallucinations and…

Computation and Language · Computer Science 2024-04-09 Pouria Rouzrokh , Shahriar Faghani , Cooper U. Gamble , Moein Shariatnia , Bradley J. Erickson