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As models of cognition grow in complexity and number of parameters, Bayesian inference with standard methods can become intractable, especially when the data-generating model is of unknown analytic form. Recent advances in simulation-based…

Machine Learning · Statistics 2020-07-14 Stefan T. Radev , Andreas Voss , Eva Marie Wieschen , Paul-Christian Bürkner

Neural posterior estimation has emerged as a powerful tool for amortized inference, with growing adoption across scientific and applied domains. In many of these applications, the conditioning variable is a set of observations whose…

Machine Learning · Computer Science 2026-05-11 Antoine Wehenkel , Michael Kagan , Lukas Heinrich , Chris Pollard

Statistical methods protecting sensitive information or the identity of the data owner have become critical to ensure privacy of individuals as well as of organizations. This paper investigates anonymization methods based on representation…

Machine Learning · Statistics 2018-02-27 Clément Feutry , Pablo Piantanida , Yoshua Bengio , Pierre Duhamel

Quantifying the uncertainty in predictive models is critical for establishing trust and enabling risk-informed decision making for personalized medicine. In contrast to one-size-fits-all approaches that seek to mitigate risk at the…

Computational Engineering, Finance, and Science · Computer Science 2025-05-15 Graham Pash , Umberto Villa , David A. Hormuth , Thomas E. Yankeelov , Karen Willcox

Many current Internet services rely on inferences from models trained on user data. Commonly, both the training and inference tasks are carried out using cloud resources fed by personal data collected at scale from users. Holding and using…

Machine Learning · Computer Science 2018-04-04 Sandra Servia-Rodriguez , Liang Wang , Jianxin R. Zhao , Richard Mortier , Hamed Haddadi

Amortized Bayesian inference (ABI) with neural networks can solve probabilistic inverse problems orders of magnitude faster than classical methods. However, ABI is not yet sufficiently robust for widespread and safe application. When…

Machine Learning · Statistics 2026-03-04 Aayush Mishra , Daniel Habermann , Marvin Schmitt , Stefan T. Radev , Paul-Christian Bürkner

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

The vision of personalized medicine is to identify interventions that maintain or restore a person's health based on their individual biology. Medical digital twins, computational models that integrate a wide range of health-related data…

Quantitative Methods · Quantitative Biology 2025-10-21 Luis L. Fonseca , Lucas Böttcher , Borna Mehrad , Reinhard C. Laubenbacher

Personalization is the process of fitting a model to patient data, a critical step towards application of multi-physics computational models in clinical practice. Designing robust personalization algorithms is often a tedious,…

Industrial process optimization and control is crucial to increase economic and ecologic efficiency. However, data sovereignty, differing goals, or the required expert knowledge for implementation impede holistic implementation. Further,…

Machine Learning · Computer Science 2024-08-28 Johannes Emmert , Ronald Mendez , Houman Mirzaalian Dastjerdi , Christopher Syben , Andreas Maier

We consider two federated learning algorithms for training partially personalized models, where the shared and personal parameters are updated either simultaneously or alternately on the devices. Both algorithms have been proposed in the…

Machine Learning · Computer Science 2022-08-17 Krishna Pillutla , Kshitiz Malik , Abdelrahman Mohamed , Michael Rabbat , Maziar Sanjabi , Lin Xiao

Private inference refers to a two-party setting in which one has a model (e.g., a linear classifier), the other has data, and the model is to be applied over the data while safeguarding the privacy of both parties. In particular, models in…

Information Theory · Computer Science 2023-05-09 Zirui Deng , Netanel Raviv

There is a known tension between the need to analyze personal data to drive business and privacy concerns. Many data protection regulations, including the EU General Data Protection Regulation (GDPR) and the California Consumer Protection…

Cryptography and Security · Computer Science 2022-02-02 Abigail Goldsteen , Gilad Ezov , Ron Shmelkin , Micha Moffie , Ariel Farkash

Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine…

Image anonymization is widely adapted in practice to comply with privacy regulations in many regions. However, anonymization often degrades the quality of the data, reducing its utility for computer vision development. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2023-06-09 Håkon Hukkelås , Frank Lindseth

The integration of human and artificial intelligence offers a powerful avenue for advancing our understanding of information processing, as each system provides unique computational insights. However, despite the promise of human-AI…

Neurons and Cognition · Quantitative Biology 2025-04-22 Stephen Chong Zhao , Yang Hu , Jason Lee , Andrew Bender , Trisha Mazumdar , Mark Wallace , David A. Tovar

Amortized inference promises fast test-time Bayesian inference, but existing methods are inherently tied to fixed models. Extending amortization to unseen models typically requires retraining or costly test-time finetuning. In this paper,…

Machine Learning · Computer Science 2026-05-27 Joohwan Ko , Justin Domke

Understanding user identity and behavior is central to applications such as personalization, recommendation, and decision support. Most existing approaches rely on deterministic embeddings or black-box predictive models, offering limited…

Machine Learning · Computer Science 2025-12-23 Daniel David

Evaluating different training interventions to determine which produce the best learning outcomes is one of the main challenges faced by instructional designers. Typically, these designers use A/B experiments to evaluate each intervention;…

Artificial Intelligence · Computer Science 2024-08-27 Christopher James MacLellan , Kimberly Stowers , Lisa Brady

Good training data is a prerequisite to develop useful ML applications. However, in many domains existing data sets cannot be shared due to privacy regulations (e.g., from medical studies). This work investigates a simple yet unconventional…

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