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This work presents a framework for modeling three-dimensional scaffold-mediated bone regeneration and the associated optimization problem. By incorporating microstructure into the model through periodic homogenization, we capture the…

Numerical Analysis · Mathematics 2025-03-25 Patrick Dondl , Oliver Suchan

Progresses in additive manufacturing technologies allow the realization of finely graded microstructured materials with tunable mechanical properties. This paves the way to a wealth of innovative applications, calling for the combined…

Analysis of PDEs · Mathematics 2023-07-10 Stefano Almi , Ulisse Stefanelli

Vertical equilibrium models have proven to be well suited for simulating fluid flow in subsurface porous media such as saline aquifers with caprocks. However, in most cases the dimensionally reduced model lacks the accuracy to capture the…

Fluid Dynamics · Physics 2024-05-29 Ivan Buntic , Martin Schneider , Bernd Flemisch , Rainer Helmig

In this paper, we present an efficient numerical method to address a thermodynamically consistent gas flow model in porous media involving compressible gas and deformable rock. The accurate modeling of gas flow in porous media often poses…

Numerical Analysis · Mathematics 2026-02-16 Huangxin Chen , Yuxiang Chen , Jisheng Kou , Shuyu Sun

This paper aims at an accurate and efficient computation of effective quantities, e.g., the homogenized coefficients for approximating the solutions to partial differential equations with oscillatory coefficients. Typical multiscale methods…

Numerical Analysis · Mathematics 2021-03-08 Assyr Abdulle , Doghonay Arjmand , Edoardo Paganoni

It is well known that the classical energetically consistent micropolar model has limits in simulating the frequency band structure of packed granular materials (see Merkel et al., 2011). It is here shown that if a standard continualization…

Soft Condensed Matter · Physics 2021-04-27 Andrea Bacigalupo , Luigi Gambarotta

In this paper, we propose a local model reduction approach for subsurface flow problems in stochastic and highly heterogeneous media. To guarantee the mass conservation, we consider the mixed formulation of the flow problem and aim to solve…

Numerical Analysis · Mathematics 2022-03-23 Yiran Wang , Eric Chung , Shubin Fu

We present a three dimensional, time dependent model for bone regeneration in the presence of porous scaffolds to bridge critical size bone defects. Our approach uses homogenized quantities, thus drastically reducing computational cost…

Analysis of PDEs · Mathematics 2021-01-25 Patrick Dondl , Patrina S. P. Poh , Marius Zeinhofer

The modeling of coupled fluid transport and deformation in a porous medium is essential to predict the various geomechanical process such as CO2 sequestration, hydraulic fracturing, and so on. Current applications of interest, for instance,…

Analysis of PDEs · Mathematics 2022-01-03 Mina Karimi , Mehrdad Massoudi , Noel Walkington , Matteo Pozzi , Kaushik Dayal

A combination of reaction-diffusion models with moving-boundary problems yields a system in which the diffusion (spreading and penetration) and reaction (transformation) evolve the system's state and geometry over time. These systems can be…

Computational Engineering, Finance, and Science · Computer Science 2020-08-26 Mojtaba Barzegari , Liesbet Geris

The evolution of local defects such as dislocations and cracks often determines the performance of engineering materials. For a proper description and understanding of these phenomena, one needs to descend to a very small scale, at which…

Soft Condensed Matter · Physics 2021-05-04 K. Mikeš , F. Bormann , O. Rokoš , R. H. J. Peerlings

In this paper, we develop and analyze an adaptive multiscale approach for heterogeneous problems in perforated domains. In many applications, these problems have a multiscale nature arising because of the perforations, their geometries, the…

Numerical Analysis · Mathematics 2016-05-26 Eric T. Chung , Yalchin Efendiev , Wing Tat Leung , Maria Vasilyeva , Yating Wang

In this paper, we propose multicontinuum splitting schemes for multiscale problems, focusing on a parabolic equation with a high-contrast coefficient. Using the framework of multicontinuum homogenization, we introduce spatially smooth…

Numerical Analysis · Mathematics 2024-10-08 Yalchin Efendiev , Wing Tat Leung , Buzheng Shan , Min Wang

Reactive transport in permeable porous media is relevant for a variety of applications, but poses a significant challenge due to the range of length and time scales. Multiscale methods that aim to link microstructure with the macroscopic…

Numerical Analysis · Mathematics 2023-12-27 Mina Karimi , Kaushik Bhattacharya

We consider the evolution of interfaces in binary mixtures permeating strongly heterogeneous systems such as porous media. To this end, we first review available thermodynamic formulations for binary mixtures based on \emph{general…

Computational Physics · Physics 2018-04-26 M. Schmuck , G. A. Pavliotis , S. Kalliadasis

We study a reaction-diffusion model posed on two distinct spatial scales that accounts for diffusion, aggregation, fragmentation, and deposition of populations of colloidal particles within a porous material. In this model, the macroscopic…

Analysis of PDEs · Mathematics 2026-04-14 Christos Nikolopoulos , Michael Eden , Adrian Muntean

We give an overview of the progress that has been made in recent years in understanding the dynamic multiscaling of homogeneous, isotropic turbulence and related problems. We emphasise the similarity of this problem with the dynamic scaling…

Chaotic Dynamics · Physics 2009-11-13 Rahul Pandit , Samriddhi Sankar Ray , Dhrubaditya Mitra

In this paper an asymptotic homogenization method for the analysis of composite materials with periodic microstructure in presence of thermodiffusion is described. Appropriate down-scaling relations correlating the microscopic fields to the…

Mathematical Physics · Physics 2015-12-31 A. Bacigalupo , L. Morini , A. Piccolroaz

We aim at understanding transport in porous materials including regions with both high and low diffusivities. For such scenarios, the transport becomes structured (here: {\em micro-macro}). The geometry we have in mind includes regions of…

Mathematical Physics · Physics 2010-03-23 T. van Noorden , A. Muntean

Note: The final version of this article was published in Computers and Geosciences, Volume 206, January 2026, 106038. DOI: 10.1016/j.cageo.2025.106038. Readers should refer to the published version for the most up-to-date content.…