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Liposomes that achieve a heterogeneous and spatially organized surface through phase separation have been recognized to be a promising platform for delivery purposes. However, their design and optimization through experimentation can be…

Soft Condensed Matter · Physics 2021-11-05 Y. Wang , Y. Palzhanov , A. Quaini , M. Olshanskii , S. Majd

We consider the homogenisation of a coupled Stokes flow and advection-reaction-diffusion problem in a perforated domain with an evolving microstructure of size $\varepsilon$. Reactions at the boundaries of the microscopic interfaces lead to…

Analysis of PDEs · Mathematics 2024-04-05 Markus Gahn , Malte A. Peter , Iuliu Sorin Pop , David Wiedemann

We study the flow generated by an incompressible viscoelastic fluid in a fractured porous medium. The model consists of a fluid flow governed by Stokes-Volterra equations evolving in a periodic double-porosity medium. Using the multiscale…

Analysis of PDEs · Mathematics 2014-07-30 Jean Louis Woukeng

We consider an advection-diffusion equation that is advection-dominated and posed on a perforated domain. On the boundary of the perforations, we set either homogeneous Dirichlet or homogeneous Neumann conditions. The purpose of this work…

Numerical Analysis · Mathematics 2017-10-26 Claude Le Bris , Frederic Legoll , Francois Madiot

In this paper, we present a robust and fully discretized method for solving the time fractional diffusion equation with high-contrast multiscale coefficients. We establish the homogenized equation using a multicontinuum approach and employ…

Numerical Analysis · Mathematics 2025-07-30 Yifei Gao , Yating Wang , Wing Tat Leung , Zhengya Yang

A mass-conservative high-order unfitted finite element method for convection-diffusion equations in evolving domains is proposed. The space-time method presented in [P. Hansbo, M. G. Larson, S. Zahedi, Comput. Methods Appl. Mech. Engrg. 307…

Numerical Analysis · Mathematics 2024-05-01 Sebastian Myrbäck , Sara Zahedi

A phase-field model for two-phase immiscible, incompressible porous media flow with surface tension effects is considered. The pore-scale model consists of a strongly coupled system of Stokes-Cahn-Hilliard equations. The fluids are…

Analysis of PDEs · Mathematics 2023-01-25 Nitu Lakhmara , Hari Shankar Mahato

Detailed understanding of the coupling between fluid flow and solid deformation in porous media is crucial for the development biomedical devices and novel energy technologies relating to a wide range of geological and biological processes.…

Fluid Dynamics · Physics 2021-09-22 Francisco J. Carrillo

Coherent X-ray scattering (CXS) techniques are capable of interrogating dynamics of nano- to mesoscale materials systems at time scales spanning several orders of magnitude. However, obtaining accurate theoretical descriptions of complex…

Additive manufacturing methods together with topology optimization have enabled the creation of multiscale structures with controlled spatially-varying material microstructure. However, topology optimization or inverse design of such…

Materials Science · Physics 2024-08-28 Harikrishnan Vijayakumaran , Jonathan B. Russ , Glaucio H. Paulino , Miguel A. Bessa

Microstructure reconstruction is a key enabler of process-structure-property linkages, a central topic in materials engineering. Revisiting classical optimization-based reconstruction techniques,they are recognized as a powerful framework…

Materials Science · Physics 2021-03-19 Paul Seibert , Marreddy Ambati , Alexander Raßloff , Markus Kästner

In this paper, we derive upscaled equations for modelling biofilm growth in porous media. The resulting macro-scale mathematical models consider permeable multi-species biofilm including water flow, transport, detachment and reactions. The…

In this paper, we present a residual-driven multiscale method for simulating Darcy flow in perforated domains, where complex geometries and highly heterogeneous permeability make direct simulations computationally expensive. To address…

Numerical Analysis · Mathematics 2026-03-11 Wei Xie , Shubin Fu , Yin Yang , Yunqing Huang

Multiscale analysis of a degenerate pseudoparabolic variational inequality, modelling the two-phase flow with dynamical capillary pressure in a perforated domain, is the main topic of this work. Regularisation and penalty operator methods…

Analysis of PDEs · Mathematics 2018-10-01 Mariya Ptashnyk

Pseudo-parabolic equations have been used to model unsaturated fluid flow in porous media. In this paper it is shown how a pseudo-parabolic equation can be upscaled when using a spatio-temporal decomposition employed in the…

Analysis of PDEs · Mathematics 2018-10-09 Arthur J. Vromans , Fons van de Ven , Adrian Muntean

We develop coarse-grained particle approaches for studying the elastic mechanics of vesicles with heterogeneous membranes having phase-separated domains. We perform simulations both of passive shape fluctuations and of active systems where…

Soft Condensed Matter · Physics 2023-02-28 David A. Rower , Paul J. Atzberger

Highly heterogeneous, anisotropic coefficients, e.g. in the simulation of carbon-fibre composite components, can lead to extremely challenging finite element systems. Direct solvers for the resulting large and sparse linear systems suffer…

Numerical Analysis · Mathematics 2021-06-16 Peter Bastian , Robert Scheichl , Linus Seelinger , Arne Strehlow

In this paper, we propose a computational framework,which is based on a domain decomposition technique, to employ both finite element method (which is a popular continuum modeling approach) and lattice Boltzmann method (which is a popular…

Computational Engineering, Finance, and Science · Computer Science 2017-08-02 S. Karimi , K. B. Nakshatrala

This paper is concerned with the numerical solution of compressible fluid flow in a fractured porous medium. The fracture represents a fast pathway (i.e., with high permeability) and is modeled as a hypersurface embedded in the porous…

Numerical Analysis · Mathematics 2022-02-15 Phuoc-Toan Huynh , Yanzhao Cao , Thi-Thao-Phuong Hoang

In this work, we present scalable balancing domain decomposition by constraints methods for linear systems arising from arbitrary order edge finite element discretizations of multi-material and heterogeneous 3D problems. In order to enforce…

Computational Engineering, Finance, and Science · Computer Science 2024-12-20 Santiago Badia , Alberto F. Martín , Marc Olm
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