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Pathological captioning of Whole Slide Images (WSIs), though is essential in computer-aided pathological diagnosis, has rarely been studied due to the limitations in datasets and model training efficacy. In this paper, we propose a new…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Wenkang Qin , Rui Xu , Peixiang Huang , Xiaomin Wu , Heyu Zhang , Lin Luo

In this paper, we consider the problem of visual representation learning for computational pathology, by exploiting large-scale image-text pairs gathered from public resources, along with the domain-specific knowledge in pathology.…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Xiao Zhou , Xiaoman Zhang , Chaoyi Wu , Ya Zhang , Weidi Xie , Yanfeng Wang

Vision-language models (VLMs) exhibit strong zero-shot generalization on natural images and show early promise in interpretable medical image analysis. However, existing benchmarks do not systematically evaluate whether these models truly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Tianhong Zhou , Yin Xu , Yingtao Zhu , Chuxi Xiao , Haiyang Bian , Lei Wei , Xuegong Zhang

LLM-based agents have demonstrated strong potential for autonomous machine learning, yet their applicability to health data remains limited. Existing systems often struggle to generalize across heterogeneous health data modalities, rely…

Artificial Intelligence · Computer Science 2026-02-03 Tong Xia , Weibin Li , Gang Liu , Yong Li

Limited access to mental healthcare, extended wait times, and increasing capabilities of Large Language Models (LLMs) has led individuals to turn to LLMs for fulfilling their mental health needs. However, examining the multi-turn mental…

Computation and Language · Computer Science 2025-05-29 Mohit Chandra , Siddharth Sriraman , Harneet Singh Khanuja , Yiqiao Jin , Munmun De Choudhury

Multimodal large language models (MLLMs) have made significant strides, yet they face challenges in the medical domain due to limited specialized knowledge. While recent medical MLLMs demonstrate strong performance in lab settings, they…

Computation and Language · Computer Science 2024-10-22 Junda Wang , Yujan Ting , Eric Z. Chen , Hieu Tran , Hong Yu , Weijing Huang , Terrence Chen

Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis…

Computation and Language · Computer Science 2025-05-21 Kevin Wu , Eric Wu , Rahul Thapa , Kevin Wei , Angela Zhang , Arvind Suresh , Jacqueline J. Tao , Min Woo Sun , Alejandro Lozano , James Zou

Vision-threatening eye diseases pose a major global health burden, with timely diagnosis limited by workforce shortages and restricted access to specialized care. While multimodal large language models (MLLMs) show promise for medical image…

Recent advances in whole slide imaging (WSI) technology have led to the development of a myriad of computer vision and artificial intelligence (AI) based diagnostic, prognostic, and predictive algorithms. Computational Pathology (CPath)…

Medical imaging benchmarks often evaluate VLMs on pre-selected 2D images, slices, crops, or patches, making evaluation closer to visual recognition. Real clinical workflows impose a different burden: readers must search through complete…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Weixiang Shen , Chengzhi Shen , Yanzhu Hu , Che Liu , Junde Wu , Jiayuan Zhu , Xiao Han , Zongyue Li , Jingpei Wu , Min Xu , Daguang Xu , Yueming Jin , Benedikt Wiestler , Daniel Rueckert , Jiazhen Pan

Biased AI-generated medical advice and misdiagnoses can jeopardize patient safety, making the integrity of AI in healthcare more critical than ever. As Large Language Models (LLMs) take on a growing role in medical decision-making,…

Computation and Language · Computer Science 2024-10-10 Pardis Sadat Zahraei , Zahra Shakeri

Recent advances in multimodal large language models (LLMs) have highlighted their potential for medical and surgical applications. However, existing surgical datasets predominantly adopt a Visual Question Answering (VQA) format with…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Tae-Min Choi , Tae Kyeong Jeong , Garam Kim , Jaemin Lee , Yeongyoon Koh , In Cheul Choi , Jae-Ho Chung , Jong Woong Park , Juyoun Park

Large language model (LLM)--based agents have emerged as pivotal tools in assisting human experts across various fields by transforming complex tasks into more efficient workflows and providing actionable stakeholder insights. Despite their…

Human-Computer Interaction · Computer Science 2025-05-13 Xiaoshan Huang , Jie Gao , Haolun Wu

While recent advancements in Large Language Models have significantly advanced dermatological diagnosis, monolithic LLMs frequently struggle with fine-grained, large-scale multi-class diagnostic tasks and rare skin disease diagnosis owing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Zhangtianyi Chen , Yuhao Shen , Florensia Widjaja , Yan Xu , Liyuan Sun , Zijian Wang , Hongyi Chen , Wufei Dai , Juexiao Zhou

Though Large Vision-Language Models (LVLMs) are being actively explored in medicine, their ability to conduct complex real-world telemedicine consultations combining accurate diagnosis with professional dialogue remains underexplored. This…

Human-Computer Interaction · Computer Science 2025-11-12 Ivan Sviridov , Amina Miftakhova , Artemiy Tereshchenko , Galina Zubkova , Pavel Blinov , Andrey Savchenko

Large visual language models (VLMs) have shown strong multi-modal medical reasoning ability, but most operate as end-to-end black boxes, diverging from clinicians' evidence-based, staged workflows and hindering clinical accountability.…

Artificial Intelligence · Computer Science 2026-03-12 Yuexi Du , Jinglu Wang , Shujie Liu , Nicha C. Dvornek , Yan Lu

Advances in optical microscopy scanning have significantly contributed to computational pathology (CPath) by converting traditional histopathological slides into whole slide images (WSIs). This development enables comprehensive digital…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Xitong Ling , Yuanyuan Lei , Jiawen Li , Junru Cheng , Wenting Huang , Tian Guan , Jian Guan , Yonghong He

In today's data-driven era, fully automated end-to-end data analytics, particularly insight discovery, is critical for discovering actionable insights that assist organizations in making effective decisions. With the rapid advancement of…

Artificial Intelligence · Computer Science 2025-11-25 Xiaochuan Liu , Yuanfeng Song , Xiaoming Yin , Xing Chen

Recent advancements in Large Vision-Language Models (LVLMs) have significantly enhanced their ability to integrate visual and linguistic information, achieving near-human proficiency in tasks like object recognition, captioning, and visual…

Computer Vision and Pattern Recognition · Computer Science 2025-05-14 Zhikai Wang , Jiashuo Sun , Wenqi Zhang , Zhiqiang Hu , Xin Li , Fan Wang , Deli Zhao

The emergence of pathology foundation models has revolutionized computational histopathology, enabling highly accurate, generalized whole-slide image analysis for improved cancer diagnosis, and prognosis assessment. While these models show…