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In patients with primary biliary cholangitis (PBC), the serum liver biochemistry measured during treatment with ursodeoxycholic acid (the UDCA response) accurately predicts long-term outcome. In this study we sought to use liver…

We introduce a new approach for topic modeling that is supervised by survival analysis. Specifically, we build on recent work on unsupervised topic modeling with so-called anchor words by providing supervision through an elastic-net…

Machine Learning · Statistics 2017-12-08 George H. Chen , Jeremy C. Weiss

ICU mortality risk prediction is a tough yet important task. On one hand, due to the complex temporal data collected, it is difficult to identify the effective features and interpret them easily; on the other hand, good prediction can help…

Machine Learning · Computer Science 2018-10-10 Guoqing Chao , Chengsheng Mao , Fei Wang , Yuan Zhao , Yuan Luo

In this paper, uniqueness properties of a coupled tensor model are studied. This new coupled tensor model is used in a new method called Partial Coupled Tensor Factorization of 3D marginals or PCTF3D. This method performs estimation of…

Signal Processing · Electrical Eng. & Systems 2025-09-08 Philippe Flores , Konstantin Usevich , David Brie

We present a generative approach to classify scarcely observed longitudinal patient trajectories. The available time series are represented as tensors and factorized using generative deep recurrent neural networks. The learned factors…

Machine Learning · Computer Science 2018-11-29 Edward De Brouwer , Jaak Simm , Adam Arany , Yves Moreau

Computed tomography perfusion (CTP) at admission is routinely used to estimate the ischemic core and penumbra, while follow-up diffusion-weighted MRI (DWI) provides the definitive infarct outcome. However, single time-point segmentations…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Md Sazidur Rahman , Kjersti Engan , Kathinka Dæhli Kurz , Mahdieh Khanmohammadi

We develop a hierarchical infinite latent factor model (HIFM) to appropriately account for the covariance structure across subpopulations in data. We propose a novel Hierarchical Dirichlet Process shrinkage prior on the loadings matrix that…

Applications · Statistics 2018-07-25 Elizabeth Lorenzi , Ricardo Henao , Katherine Heller

To date, developing a good model for early intensive care unit (ICU) mortality prediction is still challenging. This paper presents a patient based predictive modeling framework (PPMF) to improve the performance of ICU mortality prediction…

Machine Learning · Computer Science 2017-05-02 Mohammad Amin Morid , Olivia R. Liu Sheng , Samir Abdelrahman

Continual learning, the ability of a model to learn over time without forgetting previous knowledge and, therefore, be adaptive to new data, is paramount in dynamic fields such as disease outbreak prediction. Deep neural networks, i.e.,…

Machine Learning · Computer Science 2024-01-18 Saba Aslam , Abdur Rasool , Hongyan Wu , Xiaoli Li

Background and Objectives: Multidrug Resistance (MDR) is a critical global health issue, causing increased hospital stays, healthcare costs, and mortality. This study proposes an interpretable Machine Learning (ML) framework for MDR…

We propose a computationally efficient algorithm for seizure detection. Instead of using a purely data-driven approach, we develop a hybrid model-based/data-driven method, combining convolutional neural networks with factor graph inference.…

Signal Processing · Electrical Eng. & Systems 2021-08-06 Bahareh Salafian , Eyal Fishel Ben , Nir Shlezinger , Sandrine de Ribaupierre , Nariman Farsad

Most prediction models that are used in medical research fail to accurately predict health outcomes due to methodological limitations. Using routinely collected patient data, we explore the use of a Cox proportional hazard (PH) model within…

Methodology · Statistics 2019-07-19 John Mbotwa , Marc de Kamps , Paul D. Baxter , Mark S. Gilthorpe

Disease progression models infer group-level temporal trajectories of change in patients' features as a chronic degenerative condition plays out. They provide unique insight into disease biology and staging systems with individual-level…

Machine Learning · Computer Science 2025-06-25 Peter A. Wijeratne , Daniel C. Alexander

In various web applications like targeted advertising and recommender systems, the available categorical features (e.g., product type) are often of great importance but sparse. As a widely adopted solution, models based on Factorization…

Machine Learning · Computer Science 2019-11-19 Tong Chen , Hongzhi Yin , Quoc Viet Hung Nguyen , Wen-Chih Peng , Xue Li , Xiaofang Zhou

The incidence and mortality rates of malignant tumors, such as acute leukemia, have risen significantly. Clinically, hospitals rely on cytological examination of peripheral blood and bone marrow smears to diagnose malignant tumors, with…

Image and Video Processing · Electrical Eng. & Systems 2024-10-14 Yifei Chen , Zhu Zhu , Shenghao Zhu , Linwei Qiu , Binfeng Zou , Fan Jia , Yunpeng Zhu , Chenyan Zhang , Zhaojie Fang , Feiwei Qin , Jin Fan , Changmiao Wang , Yu Gao , Gang Yu

Rheumatoid arthritis is a chronic autoimmune disease that is a major public health challenge. The disease is characterised by inflammation of synovial joints and cartilage erosion, which leads to chronic pain, poor life quality and, in some…

Quantitative Methods · Quantitative Biology 2020-01-07 Fiona R Macfarlane , Mark AJ Chaplain , Raluca Eftimie

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi

Purpose: To develop a novel deep-learning model that integrates radiomics analysis in a multi-dimensional feature fusion workflow for glioblastoma (GBM) post-resection survival prediction. Methods: A cohort of 235 GBM patients with complete…

Medical Physics · Physics 2022-03-14 Zongsheng Hu , Zhenyu Yang , Haozhao Zhang , Eugene Vaios , Kyle Lafata , Fang-Fang Yin , Chunhao Wang

Colonoscopy screening effectively identifies and removes polyps before they progress to colorectal cancer (CRC), but current follow-up guidelines rely primarily on histopathological features, overlooking other important CRC risk factors.…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Shuai Jiang , Christina Robinson , Joseph Anderson , William Hisey , Lynn Butterly , Arief Suriawinata , Saeed Hassanpour

Continuous-time multistate models are widely used for analyzing interval-censored data on disease progression over time. Sometimes, diseases manifest differently and what appears to be a coherent collection of symptoms is the expression of…

Methodology · Statistics 2024-10-08 Yidan Shi , Leilei Zeng , Mary E. Thompson , Suzanne L. Tyas
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