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Accurate and reliable positioning is crucial for perception, decision-making, and other high-level applications in autonomous driving, unmanned aerial vehicles, and intelligent robots. Given the inherent limitations of standalone sensors,…

Robotics · Computer Science 2025-01-17 Zhuo Xu , Feng Zhu , Zihang Zhang , Chang Jian , Jiarui Lv , Yuantai Zhang , Xiaohong Zhang

The traditional visual-inertial SLAM system often struggles with stability under low-light or motion-blur conditions, leading to potential lost of trajectory tracking. High accuracy and robustness are essential for the long-term and stable…

Robotics · Computer Science 2024-11-05 Hongkun Luo , Yang Liu , Chi Guo , Zengke Li , Weiwei Song

Advancements in AI for science unlocks capabilities for critical drug discovery tasks such as protein-ligand binding affinity prediction. However, current models overfit to existing oversimplified datasets that does not represent naturally…

Machine Learning · Computer Science 2025-12-02 Ming-Hsiu Wu , Ziqian Xie , Shuiwang Ji , Degui Zhi

Recent advancements in protein docking site prediction have highlighted the limitations of traditional rigid docking algorithms, like PIPER, which often neglect critical stochastic elements such as solvent-induced fluctuations. These…

Quantitative Methods · Quantitative Biology 2024-12-02 Nanjie Chen , Dongliang Yu , Dmitri Beglov , Mark Kon , Julio Enrique Castrillon-Candas

Molecular docking is an essential tool for drug design. It helps the scientist to rapidly know if two molecules, respectively called ligand and receptor, can be combined together to obtain a stable complex. We propose a new multi-objective…

Quantitative Methods · Quantitative Biology 2008-11-05 Jean-Charles Boisson , Laetitia Jourdan , El-Ghazali Talbi , Dragos Horvath

Image splicing is a very common image manipulation technique that is sometimes used for malicious purposes. A splicing detec- tion and localization algorithm usually takes an input image and produces a binary decision indicating whether the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-30 Yue Wu , Wael AbdAlmageed , Prem Natarajan

Drug discovery is the most expensive, time demanding and challenging project in biopharmaceutical companies which aims at the identification and optimization of lead compounds from large-sized chemical libraries. The lead compounds should…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-12-02 Natarajan Arul Murugan , Artur Podobas , Davide Gadioli , Emanuele Vitali , Gianluca Palermo , Stefano Markidis

Virtual screening (VS) is an essential task in drug discovery, focusing on the identification of small-molecule ligands that bind to specific protein pockets. Existing deep learning methods, from early regression models to recent…

Machine Learning · Computer Science 2025-11-11 Bowei He , Bowen Gao , Yankai Chen , Yanyan Lan , Chen Ma , Philip S. Yu , Ya-Qin Zhang , Wei-Ying Ma

In drug discovery, molecular docking is the task in charge of estimating the position of a molecule when interacting with the docking site. This task is usually used to perform screening of a large library of molecules, in the early phase…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-01-21 Emanuele Vitali , Davide Gadioli , Gianluca Palermo , Andrea Beccari , Carlo Cavazzoni , Cristina Silvano

Leveraging line features to improve localization accuracy of point-based visual-inertial SLAM (VINS) is gaining interest as they provide additional constraints on scene structure. However, real-time performance when incorporating line…

Robotics · Computer Science 2022-04-18 Qiang Fu , Jialong Wang , Hongshan Yu , Islam Ali , Feng Guo , Yijia He , Hong Zhang

Built on top of self-attention mechanisms, vision transformers have demonstrated remarkable performance on a variety of vision tasks recently. While achieving excellent performance, they still require relatively intensive computational cost…

Computer Vision and Pattern Recognition · Computer Science 2021-12-01 Lingchen Meng , Hengduo Li , Bor-Chun Chen , Shiyi Lan , Zuxuan Wu , Yu-Gang Jiang , Ser-Nam Lim

While Vision-Language Models (VLMs) have achieved remarkable progress in static visual understanding, their deployment in complex 3D embodied environments remains severely limited. Existing benchmarks suffer from four critical deficiencies:…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Ruizhi Zhang , Ye Huang , Yuangang Pan , Chuanfu Shen , Zhilin Liu , Ting Xie , Wen Li , Lixin Duan

Protein complex formation is a central problem in biology, being involved in most of the cell's processes, and essential for applications, e.g. drug design or protein engineering. We tackle rigid body protein-protein docking, i.e.,…

Artificial Intelligence · Computer Science 2022-03-16 Octavian-Eugen Ganea , Xinyuan Huang , Charlotte Bunne , Yatao Bian , Regina Barzilay , Tommi Jaakkola , Andreas Krause

Molecular docking is an essential step in the drug discovery process involving the detection of three-dimensional poses of a ligand inside the active site of the protein. In this paper, we address the Molecular Docking search phase by…

Recent advances in Vision-Language-Action (VLA) models have opened new avenues for robot manipulation, yet existing methods exhibit limited efficiency and a lack of high-level knowledge and spatial awareness. To address these challenges, we…

Despite recent advances in protein-ligand structure prediction, deep learning methods remain limited in their ability to accurately predict binding affinities, particularly for novel protein targets dissimilar from the training set. In…

Quantitative Methods · Quantitative Biology 2025-12-04 Michael Brocidiacono , James Wellnitz , Konstantin I. Popov , Alexander Tropsha

The rise of Multimodal Large Language Models (MLLMs), renowned for their advanced instruction-following and reasoning capabilities, has significantly propelled the field of visual reasoning. However, due to limitations in their image…

Computer Vision and Pattern Recognition · Computer Science 2024-06-19 Jiaxing Chen , Yuxuan Liu , Dehu Li , Xiang An , Weimo Deng , Ziyong Feng , Yongle Zhao , Yin Xie

The performance of promptable video object segmentation (PVOS) models substantially degrades under input corruptions, which prevents PVOS deployment in safety-critical domains. This paper offers the first comprehensive study on robust PVOS…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Sohyun Lee , Yeho Gwon , Lukas Hoyer , Konrad Schindler , Christos Sakaridis , Suha Kwak

Smart farming and precision agriculture represent game-changer technologies for efficient and sustainable agribusiness. Miniaturized palm-sized drones can act as flexible smart sensors inspecting crops, looking for early signs of potential…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Luca Crupi , Luca Butera , Alberto Ferrante , Daniele Palossi

Current multimodal large lanauge models possess strong perceptual and reasoning capabilities, however high computational and memory requirements make them difficult to deploy directly on on-device environments. While small-parameter models…

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