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We present VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration. Traditional registration methods optimize an objective function for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

The majority of current research in deep learning based image registration addresses inter-patient brain registration with moderate deformation magnitudes. The recent Learn2Reg medical registration benchmark has demonstrated that…

Computer Vision and Pattern Recognition · Computer Science 2022-03-02 Mattias P. Heinrich , Lasse Hansen

Purpose: This study aims to explore training strategies to improve convolutional neural network-based image-to-image deformable registration for abdominal imaging. Methods: Different training strategies, loss functions, and transfer…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Javier Pérez de Frutos , André Pedersen , Egidijus Pelanis , David Bouget , Shanmugapriya Survarachakan , Thomas Langø , Ole-Jakob Elle , Frank Lindseth

Deformable image registration estimates voxel-wise correspondences between images through spatial transformations, and plays a key role in medical imaging. While deep learning methods have significantly reduced runtime, efficiently handling…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Tianran Li , Marius Staring , Yuchuan Qiao

Spatially aligning medical images from different modalities remains a challenging task, especially for intraoperative applications that require fast and robust algorithms. We propose a weakly-supervised, label-driven formulation for…

Computer Vision and Pattern Recognition · Computer Science 2018-06-05 Yipeng Hu , Marc Modat , Eli Gibson , Nooshin Ghavami , Ester Bonmati , Caroline M. Moore , Mark Emberton , J. Alison Noble , Dean C. Barratt , Tom Vercauteren

Cross-modal 3D medical image analysis requires voxelwise representations that remain anatomically consistent across imaging contrasts, scanners, and acquisition protocols. Recent work has shown that frozen 2D Vision Transformer (ViT)…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Guney Tombak , Ertunc Erdil , Ender Konukoglu

Image registration is the process of bringing different images into a common coordinate system - a technique widely used in various applications of computer vision, such as remote sensing, image retrieval, and, most commonly, medical…

This study investigates the use of the unsupervised deep learning framework VoxelMorph for deformable registration of longitudinal abdominopelvic CT images acquired in patients with bone metastases from breast cancer. The CT images were…

Deep Learning in Image Registration (DLIR) methods have been tremendously successful in image registration due to their speed and ability to incorporate weak label supervision at training time. However, existing DLIR methods forego many of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Rohit Jena , Pratik Chaudhari , James C. Gee

Recent successes in deep learning based deformable image registration (DIR) methods have demonstrated that complex deformation can be learnt directly from data while reducing computation time when compared to traditional methods. However,…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Sharib Ali , Jens Rittscher

One of the fundamental challenges in supervised learning for multimodal image registration is the lack of ground-truth for voxel-level spatial correspondence. This work describes a method to infer voxel-level transformation from…

Deformable image registration (DIR) remains a fundamental yet challenging problem in medical image analysis, largely due to the prohibitively high-dimensional deformation space of dense displacement fields and the scarcity of voxel-level…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Runxun Zhang , Yizhou Liu , Li Dongrui , Bo XU , Jingwei Wei

Learning-based deformable image registration (DIR) accelerates alignment by amortizing traditional optimization via neural networks. Label supervision further enhances accuracy, enabling efficient and precise nonlinear alignment of unseen…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Hang Zhang , Xiang Chen , Renjiu Hu , Rongguang Wang , Jinwei Zhang , Min Liu , Yaonan Wang , Gaolei Li , Xinxing Cheng , Jinming Duan

Cone-beam CT (CBCT)-based online adaptive radiotherapy calls for accurate auto-segmentation to reduce the time cost for physicians to edit contours. However, deep learning (DL)-based direct segmentation of CBCT images is a challenging task,…

Medical Physics · Physics 2023-02-22 Xiao Liang , Howard Morgan , Ti Bai , Michael Dohopolski , Dan Nguyen , Steve Jiang

Deformable image registration (DIR) is an enabling technology in many diagnostic and therapeutic tasks. Despite this, DIR algorithms have limited clinical use, largely due to a lack of benchmark datasets for quality assurance during…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Edward R Criscuolo , Yao Hao , Zhendong Zhang , Trevor McKeown , Deshan Yang

Deformable image registration (DIR) is a crucial tool in radiotherapy for analyzing anatomical changes and motion patterns. Current DIR implementations rely on discrete volumetric motion representation, which often leads to compromised…

Medical Physics · Physics 2025-07-22 Xia Li , Runzhao Yang , Muheng Li , Xiangtai Li , Antony J. Lomax , Joachim M. Buhmann , Ye Zhang

3D semantic occupancy prediction aims to reconstruct the 3D geometry and semantics of the surrounding environment. With dense voxel labels, prior works typically formulate it as a dense segmentation task, independently classifying each…

Graphics · Computer Science 2025-06-06 Wuyang Li , Zhu Yu , Alexandre Alahi

Vision-language pre-training (VLP) has recently proven highly effective for various uni- and multi-modal downstream applications. However, most existing end-to-end VLP methods use high-resolution image-text box data to perform well on…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Shraman Pramanick , Li Jing , Sayan Nag , Jiachen Zhu , Hardik Shah , Yann LeCun , Rama Chellappa

We propose MaxDIRep, a domain adaptation method that improves the decomposition of data representations into domain-independent and domain-dependent components. Existing methods, such as Domain-Separation Networks (DSN), use a weak…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Adrian Shuai Li , Elisa Bertino , Xuan-Hong Dang , Ankush Singla , Yuhai Tu , Mark N Wegman

The thickness of the cortical band is linked to various neurological and psychiatric conditions, and is often estimated through surface-based methods such as Freesurfer in MRI studies. The DiReCT method, which calculates cortical thickness…

Image and Video Processing · Electrical Eng. & Systems 2023-07-24 Richard McKinley , Christian Rummel
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