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A persistent challenge in predictive molecular modeling of thermoset polymers is to capture the effects of chemical composition and degree of crosslinking (DC) on dynamical and mechanical properties with high computational efficiency. We…

Soft Condensed Matter · Physics 2021-10-15 Andrea Giuntoli , Nitin K. Hansoge , Anton van Beek , Zhaoxu Meng , Wei Chen , Sinan Keten

Multiscale simulations facilitate the efficient exploration of large spatiotemporal scales in chemical and physical systems, yet particle-based simulations become prohibitively expensive at time and length scales beyond the molecular level.…

Chemical Physics · Physics 2026-02-25 Jaehyeok Jin , Yining Han , Gregory A. Voth

The development of reliable and extensible molecular mechanics (MM) force fields -- fast, empirical models characterizing the potential energy surface of molecular systems -- is indispensable for biomolecular simulation and computer-aided…

We introduce a machine-learning-based coarse-grained molecular dynamics (CGMD) model that faithfully retains the many-body nature of the inter-molecular dissipative interactions. Unlike common empirical CG models, the present model is…

Computational Physics · Physics 2023-12-01 Liyao Lyu , Huan Lei

Gaussian process (GP) emulator has been used as a surrogate model for predicting force field and molecular potential, to overcome the computational bottleneck of molecular dynamics simulation. Integrating both atomic force and energy in…

Chemical Physics · Physics 2022-05-13 Hao Li , Musen Zhou , Jessalyn Sebastian , Jianzhong Wu , Mengyang Gu

Accurate prediction of energy and forces for 3D molecular systems is one of fundamental challenges at the core of AI for Science applications. Many powerful and data-efficient neural networks predict molecular energies and forces from…

Chemical Physics · Physics 2026-04-23 Ali Mollahosseini , Mohammed Haroon Dupty , Wee Sun Lee

Atomic Force Microscopy (AFM) operating in the frequency modulation mode with a metal tip functionalized with a CO molecule images the internal structure of molecules with an unprecedented resolution. The interpretation of these images is…

Materials Science · Physics 2022-12-29 Jaime Carracedo-Cosme , Rubén Pérez

Machine Learning (ML) has widely been used for modeling and predicting physical systems. These techniques offer high expressive power and good generalizability for interpolation within observed data sets. However, the disadvantage of…

Machine Learning · Statistics 2023-03-02 Omid Sedehi , Antonina M. Kosikova , Costas Papadimitriou , Lambros S. Katafygiotis

We propose a sampling algorithm relying on a collective variable (CV) of mid-size dimension modelled by a normalizing flow and using non-equilibrium dynamics to propose full configurational moves from the proposition of a refreshed value of…

Statistical Mechanics · Physics 2024-07-29 Samuel Tamagnone , Alessandro Laio , Marylou Gabrié

The dynamics of real magnets is often governed by several interacting processes taking place simultaneously at different length scales. For dynamical simulations the relevant length scales should be coupled, and the energy transfer…

Materials Science · Physics 2007-05-23 V. V. Dobrovitski , M. I. Katsnelson , B. N. Harmon

The combination of high-dimensionality and disparity of time scales encountered in many problems in computational physics has motivated the development of coarse-grained (CG) models. In this paper, we advocate the paradigm of data-driven…

Computational Physics · Physics 2018-03-05 L. Felsberger , P. S. Koutsourelakis

We propose a new multi-scale molecular dynamics simulation method which can achieve high accuracy and high sampling efficiency simultaneously without aforehand knowledge of the coarse grained (CG) potential and test it for a biomolecular…

Biological Physics · Physics 2009-08-05 Wenfei Li , Shoji Takada

We implemented a coarse-graining procedure to construct mesoscopic models of complex molecules. The final aim is to obtain better results on properties depending on slow modes of the molecules. Therefore the number of particles considered…

Soft Condensed Matter · Physics 2009-10-31 Hendrik Meyer , Oliver Biermann , Roland Faller , Dirk Reith , Florian Mueller-Plathe

We introduce a generalized machine learning framework to probabilistically parameterize upper-scale models in the form of nonlinear PDEs consistent with a continuum theory, based on coarse-grained atomistic simulation data of mechanical…

Elastic network models, simple structure-based representations of biomolecules where atoms interact via short-range harmonic potentials, provide great insight into a molecule's internal dynamics and mechanical properties at extremely low…

Soft Condensed Matter · Physics 2018-12-12 Patrick Diggins , Changjiang Liu , Markus Deserno , Raffaello Potestio

Structural and thermodynamic consistency of coarse-graining models across multiple length scales is essential for the predictive role of multi-scale modeling and molecular dynamic simulations that use mesoscale descriptions. Our approach is…

Soft Condensed Matter · Physics 2014-07-04 J. McCarty , A. J. Clark , J. Copperman , M. G. Guenza

In order to understand the physical processes of nanopore experiments at the molecular level, microscopic information from molecular dynamics is greatly needed. Coarse-grained models are a good alternative to classical all-atom models since…

Soft Condensed Matter · Physics 2025-10-16 Delphine Dessaux , Jérôme Mathé , Rosa Ramirez , Nathalie Basdevant

We propose a generalized Langevin dynamics (GLD) technique to construct non-Markovian particle-based coarse-grained models from fine-grained reference simulations and to efficiently integrate them. The proposed GLD model has the form of a…

Soft Condensed Matter · Physics 2018-11-16 Gerhard Jung , Martin Hanke , Friederike Schmid

We have proposed an efficient parameterization method for a recent variant of the Gay-Berne potential for dissimilar and biaxial particles and demonstrated it for a set of small organic molecules. Compared to the previously proposed…

Soft Condensed Matter · Physics 2007-05-23 M. Babadi , R. Everaers , M. R. Ejtehadi

We provide a definition and explicit expressions for $n$-body Gaussian Process (GP) kernels which can learn any interatomic interaction occurring in a physical system, up to $n$-body contributions, for any value of $n$. The series is…

Computational Physics · Physics 2018-05-30 Aldo Glielmo , Claudio Zeni , Alessandro De Vita