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Generative modeling of single-cell RNA-seq data is crucial for tasks like trajectory inference, batch effect removal, and simulation of realistic cellular data. However, recent deep generative models simulating synthetic single cells from…

Quantitative Methods · Quantitative Biology 2025-03-04 Alessandro Palma , Till Richter , Hanyi Zhang , Manuel Lubetzki , Alexander Tong , Andrea Dittadi , Fabian Theis

Deep generative models, such as diffusion models, have shown promising progress in image generation and audio generation via simplified continuity assumptions. However, the development of generative modeling techniques for generating…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Wenhao Zheng , Chenwei Sun , Wenbo Zhang , Jiancheng Lv , Xianggen Liu

Recent progress in large-scale flow and diffusion models raised two fundamental algorithmic challenges: (i) control-based reward adaptation of pre-trained flows, and (ii) integration of multiple models, i.e., flow merging. While current…

Machine Learning · Computer Science 2026-02-10 Riccardo De Santi , Malte Franke , Ya-Ping Hsieh , Andreas Krause

Physics-constrained generative modeling aims to produce high-dimensional samples that are both physically consistent and distributionally accurate, a task that remains challenging due to often conflicting optimization objectives. Recent…

Machine Learning · Computer Science 2026-02-24 Giacomo Baldan , Qiang Liu , Alberto Guardone , Nils Thuerey

Flow matching is a recent framework to train generative models that exhibits impressive empirical performance while being relatively easier to train compared with diffusion-based models. Despite its advantageous properties, prior methods…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Quan Dao , Hao Phung , Binh Nguyen , Anh Tran

Masked discrete diffusion models (MDMs) are a promising new approach to generative modelling, offering the ability for parallel token generation and therefore greater efficiency than autoregressive counterparts. However, achieving an…

Machine Learning · Computer Science 2026-03-02 David Fox , Sam Bowyer , Song Liu , Laurence Aitchison , Raul Santos-Rodriguez , Mengyue Yang

Recent advances in neural-based generative modeling have reignited the hopes of having computer systems capable of conversing with humans and able to understand natural language. The employment of deep neural architectures has been largely…

Computation and Language · Computer Science 2022-11-16 Haoqin Tu , Yitong Li

Achieving high-fidelity and temporally smooth 3D human motion generation remains a challenge, particularly within resource-constrained environments. We introduce FlowMotion, a novel method leveraging Conditional Flow Matching (CFM).…

Graphics · Computer Science 2025-04-28 Manolo Canales Cuba , Vinícius do Carmo Melício , João Paulo Gois

A common objective in the analysis of tabular data is estimating the conditional distribution (in contrast to only producing predictions) of a set of "outcome" variables given a set of "covariates", which is sometimes referred to as the…

Machine Learning · Statistics 2024-10-08 Zhuoqun Wang , Naoki Awaya , Li Ma

A method based on Bayesian neural networks and genetic algorithm is proposed to control the fermentation process. The relationship between input and output variables is modelled using Bayesian neural network that is trained using hybrid…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Tshilidzi Marwala

Recent advances in autoregressive (AR) models have demonstrated their potential to rival diffusion models in image synthesis. However, for complex spatially-conditioned generation, current AR approaches rely on fine-tuning the pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Jiaqi Liu , Tao Huang , Chang Xu

Reconstructing near-wall turbulence from wall-based measurements is a critical yet inherently ill-posed problem in wall-bounded flows, where limited sensing and spatially heterogeneous flow-wall coupling challenge deterministic estimation…

Fluid Dynamics · Physics 2025-04-22 Meet Hemant Parikh , Xiantao Fan , Jian-Xun Wang

We propose Functional Flow Matching (FFM), a function-space generative model that generalizes the recently-introduced Flow Matching model to operate in infinite-dimensional spaces. Our approach works by first defining a path of probability…

Machine Learning · Computer Science 2023-12-07 Gavin Kerrigan , Giosue Migliorini , Padhraic Smyth

Strong semantic representations improve the convergence and generation quality of diffusion and flow models. Existing approaches largely rely on external models, which require separate training, operate on misaligned objectives, and exhibit…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Hila Chefer , Patrick Esser , Dominik Lorenz , Dustin Podell , Vikash Raja , Vinh Tong , Antonio Torralba , Robin Rombach

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships.…

Machine Learning · Computer Science 2025-07-08 Haoran Zhang , Mingyuan Zhou , Wesley Tansey

Flow Matching (FM) underpins many state-of-the-art generative models, yet recent results indicate that Transition Matching (TM) can achieve higher quality with fewer sampling steps. This work answers the question of when and why TM…

Machine Learning · Computer Science 2026-05-22 Jaihoon Kim , Rajarshi Saha , Minhyuk Sung , Youngsuk Park

Recently, combinations of generative and Bayesian machine learning have been introduced in particle physics for both fast detector simulation and inference tasks. These neural networks aim to quantify the uncertainty on the generated…

Machine Learning · Computer Science 2024-11-21 Sebastian Bieringer , Sascha Diefenbacher , Gregor Kasieczka , Mathias Trabs

Controllable generation, which enables fine-grained control over generated outputs, has emerged as a critical focus in visual generative models. Currently, there are two primary technical approaches in visual generation: diffusion models…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Ziyu Yao , Jialin Li , Yifeng Zhou , Yong Liu , Xi Jiang , Chengjie Wang , Feng Zheng , Yuexian Zou , Lei Li

Learning from expert demonstrations is a promising approach for training robotic manipulation policies from limited data. However, imitation learning algorithms require a number of design choices ranging from the input modality, training…

Robotics · Computer Science 2024-09-12 Eugenio Chisari , Nick Heppert , Max Argus , Tim Welschehold , Thomas Brox , Abhinav Valada

Diffusion models have recently gained significant attention in robotics due to their ability to generate multi-modal distributions of system states and behaviors. However, a key challenge remains: ensuring precise control over the generated…

Robotics · Computer Science 2025-10-01 Luobin Wang , Hongzhan Yu , Chenning Yu , Sicun Gao , Henrik Christensen