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The training of Quantum Neural Networks (QNNs) is hindered by the high computational cost of gradient estimation and the barren plateau problem, where optimization landscapes become intractably flat. To address these challenges, we…

Machine Learning · Computer Science 2026-02-13 Christopher Kverne , Mayur Akewar , Yuqian Huo , Tirthak Patel , Janki Bhimani

Optimizing routing in Wireless Sensor Networks (WSNs) is pivotal for minimizing energy consumption and extending network lifetime. This paper introduces a resourceefficient compilation method for distributed quantum circuits tailored to…

Quantum Physics · Physics 2025-01-20 Kuan-Cheng Chen , Felix Burt , Shang Yu , Chen-Yu Liu , Min-Hsiu Hsieh , Kin K. Leung

Quantum annealing is a promising approach for solving combinatorial optimization problems. However, its performance is often limited by the overhead of additional qubits required for embedding logical QUBO models onto quantum annealers.…

Quantum Physics · Physics 2026-01-27 Kohei Suda , Soshun Naito , Yoshihiko Hasegawa

Variational quantum algorithms (VQAs) represent a promising approach to utilizing current quantum computing infrastructures. VQAs are based on a parameterized quantum circuit optimized in a closed loop via a classical algorithm. This hybrid…

Quantum Physics · Physics 2024-04-10 David Fitzek , Robert S. Jonsson , Werner Dobrautz , Christian Schäfer

Recent studies on quantum computing algorithms focus on excavating features of quantum computers which have potential for contributing to computational model enhancements. Among various approaches, quantum annealing methods effectively…

Quantum Physics · Physics 2021-11-02 Sun Woo Park , Hyunju Lee , Byung Chun Kim , Youngho Woo , Kyungtaek Jun

The increasing complexity of industrial scheduling and transport routing problems motivates the study of alternative optimization formulations and computational paradigms. In this work, we study how higher-order unconstrained binary…

We present a number of quantum computing patterns that build on top of fundamental algorithms, that can be applied to solving concrete, NP-hard problems. In particular, we introduce the concept of a quantum dictionary as a summation of…

Binary Neural Networks (BiNNs), which employ single-bit precision weights, have emerged as a promising solution to reduce memory usage and power consumption while maintaining competitive performance in large-scale systems. However, training…

Quantum Physics · Physics 2025-11-18 Luca Nepote , Alix Lhéritier , Nicolas Bondoux , Marios Kountouris , Maurizio Filippone

The peptide-protein docking problem is an important problem in structural biology that facilitates rational and efficient drug design. In this work, we explore modeling and solving this problem with the quantum-amenable quadratic…

Hypergraph partitioning is a fundamental optimization problem with applications in data management and other domains involving higher-order relations. In this paper, we study balanced hypergraph partitioning from the perspective of quantum…

Social and Information Networks · Computer Science 2026-05-05 Yiran Li , Y. Batuhan Yilmaz , Michael Silver , Zachary Vernec , Hans-Arno Jacobsen

Accurate prediction of mRNA secondary structure is critical for understanding gene expression, translation efficiency, and advancing mRNA-based therapeutics. However, the combinatorial complexity of possible foldings, especially in long…

Combinatorial optimization problems are pivotal across many fields. Among these, Quadratic Unconstrained Binary Optimization (QUBO) problems, central to fields like portfolio optimization, network design, and computational biology, are…

Optimization and Control · Mathematics 2024-06-07 Yuhan Huang , Siyuan Jin , Yichi Zhang , Ling Pan , Qiming Shao

Recent studies suggest that gradient-based methods applied to relaxed box-constrained Quadratic Unconstrained Binary Optimization (QUBO) formulations can outperform classical heuristics in some large-scale regimes, often relying on heavy…

Discrete Mathematics · Computer Science 2026-05-11 Yongliang Sun , Ismail Alkhouri , Cheng-Han Huang , Alvaro Velasquez , Susmit Jha , Rongrong Wang

One of the main challenges in drug discovery is to find molecules that bind specifically and strongly to their target protein while having minimal binding to other proteins. By predicting binding affinity, it is possible to identify the…

Quantum Physics · Physics 2023-01-19 L. Domingo , M. Djukic , C. Johnson , F. Borondo

Quantum convolutional neural networks (QCNNs) represent a promising approach in quantum machine learning, paving new directions for both quantum and classical data analysis. This approach is particularly attractive due to the absence of the…

Quantum Physics · Physics 2025-08-06 Changwon Lee , Israel F. Araujo , Dongha Kim , Junghan Lee , Siheon Park , Ju-Young Ryu , Daniel K. Park

We propose an approach to solving constrained combinatorial optimization problems based on embedding the concept of Lagrangian duality into the framework of adiabatic quantum computation. Within the setting of circuit-model fault-tolerant…

Optimization and Control · Mathematics 2024-04-30 Einar Gabbassov , Gili Rosenberg , Artur Scherer

We introduce and analyze a novel quantum machine learning model motivated by convolutional neural networks. Our quantum convolutional neural network (QCNN) makes use of only $O(\log(N))$ variational parameters for input sizes of $N$ qubits,…

Quantum Physics · Physics 2019-10-23 Iris Cong , Soonwon Choi , Mikhail D. Lukin

Can near-term gate model based quantum processors offer quantum advantage for practical applications in the pre-fault tolerance noise regime? A class of algorithms which have shown some promise in this regard are the so-called…

Quantum Physics · Physics 2019-08-13 Guillaume Verdon , Michael Broughton , Jacob Biamonte

Hybrid quantum-classical optimization techniques, which incorporate the pre-optimization of Variational Quantum Algorithms (VQAs) using Tensor Networks (TNs), have been shown to allow for the reduction of quantum computational resources. In…

Quantum Physics · Physics 2025-07-16 Andrés N. Cáliz , Jordi Riu , Josep Bosch , Pau Torrente , Jose Miralles , Arnau Riera

Quantum computers are expected to offer significant advantages in solving complex optimization problems that are challenging for classical computers. Quadratic Unconstrained Binary Optimization (QUBO) problems represent an important class…

Quantum Physics · Physics 2025-10-15 Teemu Pihkakoski , Aravind Plathanam Babu , Pauli Taipale , Petri Liimatta , Matti Silveri