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Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained…

Neurons and Cognition · Quantitative Biology 2023-02-08 Yorgos M. Psarellis , Michail Kavousanakis , Michael A. Henson , Ioannis G. Kevrekidis

Continual learning (CL), which aims to learn a sequence of tasks, has attracted significant recent attention. However, most work has focused on the experimental performance of CL, and theoretical studies of CL are still limited. In…

Machine Learning · Computer Science 2023-02-14 Sen Lin , Peizhong Ju , Yingbin Liang , Ness Shroff

In this paper, we focus on a long-term continual learning (CL) task, where a model learns sequentially from a stream of vast tasks over time, acquiring new knowledge while retaining previously learned information in a manner akin to human…

Machine Learning · Computer Science 2025-05-16 Tianyu Huai , Jie Zhou , Yuxuan Cai , Qin Chen , Wen Wu , Xingjiao Wu , Xipeng Qiu , Liang He

The Dendritic Cell algorithm (DCA) is inspired by recent work in innate immunity. In this paper a formal description of the DCA is given. The DCA is described in detail, and its use as an anomaly detector is illustrated within the context…

Artificial Intelligence · Computer Science 2010-07-05 Julie Greensmith , Uwe Aickelin , Jamie Twycross

Forming accurate memory of sequential stimuli is a fundamental function of biological agents. However, the computational mechanism underlying sequential memory in the brain remains unclear. Inspired by neuroscience theories and recent…

Neurons and Cognition · Quantitative Biology 2023-10-27 Mufeng Tang , Helen Barron , Rafal Bogacz

Phase Change Memory (PCM) is an attractive candidate for main memory as it offers non-volatility and zero leakage power, while providing higher cell densities, longer data retention time, and higher capacity scaling compared to DRAM. In…

Hardware Architecture · Computer Science 2021-07-27 Aditya Narayan , Yvain Thonnart , Pascal Vivet , Ayse K. Coskun , Ajay Joshi

While deep neural networks take loose inspiration from neuroscience, it is an open question how seriously to take the analogies between artificial deep networks and biological neuronal systems. Interestingly, recent work has shown that deep…

Neurons and Cognition · Quantitative Biology 2018-05-31 William Lotter , Gabriel Kreiman , David Cox

We propose a novel method called deep convolutional decision jungle (CDJ) and its learning algorithm for image classification. The CDJ maintains the structure of standard convolutional neural networks (CNNs), i.e. multiple layers of…

Computer Vision and Pattern Recognition · Computer Science 2018-05-21 Seungryul Baek , Kwang In Kim , Tae-Kyun Kim

Lifelong learning is a very important step toward realizing robust autonomous artificial agents. Neural networks are the main engine of deep learning, which is the current state-of-the-art technique in formulating adaptive artificial…

Machine Learning · Computer Science 2019-12-11 Mohammed Amer , Tomás Maul

This paper presents a new learning algorithm, termed Deep Bi-directional Predictive Coding (DBPC) that allows developing networks to simultaneously perform classification and reconstruction tasks using the same weights. Predictive Coding…

Machine Learning · Computer Science 2023-05-31 Senhui Qiu , Saugat Bhattacharyya , Damien Coyle , Shirin Dora

Deep Learning has a hierarchical network architecture to represent the complicated feature of input patterns. The adaptive structural learning method of Deep Belief Network (DBN) has been developed. The method can discover an optimal number…

Neural and Evolutionary Computing · Computer Science 2018-08-28 Shin Kamada , Takumi Ichimura , Toshihide Harada

Spiking Neural Networks (SNNs) capture the information processing mechanism of the brain by taking advantage of spiking neurons, such as the Leaky Integrate-and-Fire (LIF) model neuron, which incorporates temporal dynamics and transmits…

Neural and Evolutionary Computing · Computer Science 2024-01-18 Zexiang Yi , Jing Lian , Yunliang Qi , Zhaofei Yu , Huajin Tang , Yide Ma , Jizhao Liu

As transistor-based memory technologies like dynamic random access memory (DRAM) approach their scalability limits, the need to explore alternative storage solutions becomes increasingly urgent. Phase-change memory (PCM) has gained…

Hardware Architecture · Computer Science 2025-12-02 Mahek Desai , Rowena Quinn , Marjan Asadinia

A key challenge in systems biology is the elucidation of the underlying principles, or fundamental laws, which determine the cellular phenotype. Understanding how these fundamental principles are altered in diseases like cancer is important…

Molecular Networks · Quantitative Biology 2014-08-06 Andrew Teschendorff , Peter Sollich , Reimer Kuehn

Click-through rate (CTR) prediction is a critical task in online advertising systems. Models like Deep Neural Networks (DNNs) are simple but stateless. They consider each target ad independently and cannot directly extract useful…

Information Retrieval · Computer Science 2019-07-23 Wentao Ouyang , Xiuwu Zhang , Shukui Ren , Li Li , Zhaojie Liu , Yanlong Du

Molecular recognition, which is essential in processing information in biological systems, takes place in a crowded noisy biochemical environment and requires the recognition of a specific target within a background of various similar…

Biomolecules · Quantitative Biology 2010-07-27 Yonatan Savir , Tsvi Tlusty

Neural network models capable of storing memory have been extensively studied in computer science and computational neuroscience. The Hopfield network is a prototypical example of a model designed for associative, or content-addressable,…

Neurons and Cognition · Quantitative Biology 2025-09-24 Marco Cafiso , Paolo Paradisi

Continual Learning (CL) is an emerging machine learning paradigm that aims to learn from a continuous stream of tasks without forgetting knowledge learned from the previous tasks. To avoid performance decrease caused by forgetting, prior…

Machine Learning · Computer Science 2023-01-02 Soobee Lee , Minindu Weerakoon , Jonghyun Choi , Minjia Zhang , Di Wang , Myeongjae Jeon

Circulating tumor cells (CTCs) are cancer cells found in the bloodstream that serve as biomarkers for early cancer detection, prognostication, and disease monitoring. However, CTC detection remains challenging due to low cell abundance and…

Current biological AI models lack interpretability -- their internal representations do not correspond to biological relationships that researchers can examine. Understanding gene regulation requires models whose learned structure can be…

Machine Learning · Computer Science 2026-03-17 Nobuyuki Ota