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Post-translational modifications (PTMs) profoundly expand the complexity and functionality of the proteome, regulating protein attributes and interactions that are crucial for biological processes. Accurately predicting PTM sites and their…

Machine Learning · Computer Science 2024-11-05 Cheng Tan , Zhenxiao Cao , Zhangyang Gao , Lirong Wu , Siyuan Li , Yufei Huang , Jun Xia , Bozhen Hu , Stan Z. Li

Local feature matching between images remains a challenging task, especially in the presence of significant appearance variations, e.g., extreme viewpoint changes. In this work, we propose DeepMatcher, a deep Transformer-based network built…

Computer Vision and Pattern Recognition · Computer Science 2023-01-10 Tao Xie , Kun Dai , Ke Wang , Ruifeng Li , Lijun Zhao

Anticancer peptides (ACPs) are a class of molecules that have gained significant attention in the field of cancer research and therapy. ACPs are short chains of amino acids, the building blocks of proteins, and they possess the ability to…

Biomolecules · Quantitative Biology 2024-01-05 Zeynep Hilal Kilimci , Mustafa Yalcin

In the low-data regime, it is difficult to train good supervised models from scratch. Instead practitioners turn to pre-trained models, leveraging transfer learning. Ensembling is an empirically and theoretically appealing way to construct…

Machine Learning · Computer Science 2020-10-20 Basil Mustafa , Carlos Riquelme , Joan Puigcerver , André Susano Pinto , Daniel Keysers , Neil Houlsby

We present a novel usage of Transformers to make image classification interpretable. Unlike mainstream classifiers that wait until the last fully connected layer to incorporate class information to make predictions, we investigate a…

The biological functions of proteins often depend on dynamic structural ensembles. In this work, we develop a flow-based generative modeling approach for learning and sampling the conformational landscapes of proteins. We repurpose highly…

Biomolecules · Quantitative Biology 2024-09-04 Bowen Jing , Bonnie Berger , Tommi Jaakkola

We investigate ensemble methods for prediction in an online setting. Unlike all the literature in ensembling, for the first time, we introduce a new approach using a meta learner that effectively combines the base model predictions via…

Machine Learning · Computer Science 2022-12-01 Arda Fazla , Mustafa Enes Aydin , Orhun Tamyigit , Suleyman Serdar Kozat

Object detectors frequently encounter significant performance degradation when confronted with domain gaps between collected data (source domain) and data from real-world applications (target domain). To address this task, numerous…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Jianhong Han , Liang Chen , Yupei Wang

Computational protein design is experiencing a transformation driven by AI/ML. However, the range of potential protein sequences and structures is astronomically vast, even for moderately sized proteins. Hence, achieving convergence between…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-09 Aymen Alsaadi , Jonathan Ash , Mikhail Titov , Matteo Turilli , Andre Merzky , Shantenu Jha , Sagar Khare

Ensemble of machine learning models yields improved performance as well as robustness. However, their memory requirements and inference costs can be prohibitively high. Knowledge distillation is an approach that allows a single model to…

Computer Vision and Pattern Recognition · Computer Science 2022-10-06 Zhengcong Fei , Shuman Tian , Junshi Huang , Xiaoming Wei , Xiaolin Wei

In online multi-target tracking, modeling of appearance and geometric similarities between pedestrians visual scenes is of great importance. The higher dimension of inherent information in the appearance model compared to the geometric…

Computer Vision and Pattern Recognition · Computer Science 2020-10-12 Young-Chul Yoon , Du Yong Kim , Young-min Song , Kwangjin Yoon , Moongu Jeon

Developers frequently use APIs to implement certain functionalities, such as parsing Excel Files, reading and writing text files line by line, etc. Developers can greatly benefit from automatic API usage sequence generation based on natural…

Software Engineering · Computer Science 2022-04-08 Mohammad Abdul Hadi , Imam Nur Bani Yusuf , Ferdian Thung , Kien Gia Luong , Jiang Lingxiao , Fatemeh H. Fard , David Lo

Post-translational modifications (PTMs) form a combinatorial "code" that regulates protein function, yet deciphering this code - linking modified sites to their catalytic enzymes - remains a central unsolved problem in understanding…

Computational Engineering, Finance, and Science · Computer Science 2025-10-28 Jingjie Zhang , Hanqun Cao , Zijun Gao , Yu Wang , Shaoning Li , Jun Xu , Cheng Tan , Jun Zhu , Chang-Yu Hsieh , Chunbin Gu , Pheng Ann Heng

Multi-agent trajectory prediction is a fundamental problem in autonomous driving. The key challenges in prediction are accurately anticipating the behavior of surrounding agents and understanding the scene context. To address these…

Computer Vision and Pattern Recognition · Computer Science 2022-03-04 Elmira Amirloo , Amir Rasouli , Peter Lakner , Mohsen Rohani , Jun Luo

Background: The inception of next generations sequencing technologies have exponentially increased the volume of biological sequence data. Protein sequences, being quoted as the `language of life', has been analyzed for a multitude of…

Quantitative Methods · Quantitative Biology 2020-12-08 Nabil Ibtehaz , S. M. Shakhawat Hossain Sourav , Md. Shamsuzzoha Bayzid , M. Sohel Rahman

Existing methods enhance the training of detection transformers by incorporating an auxiliary one-to-many assignment. In this work, we treat the model as a multi-task framework, simultaneously performing one-to-one and one-to-many…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Chang-Bin Zhang , Yujie Zhong , Kai Han

Self-assembly of dilute sequence-defined macromolecules is a complex phenomenon in which the local arrangement of chemical moieties can lead to the formation of long-range structure. The dependence of this structure on the sequence…

Soft Condensed Matter · Physics 2022-06-08 Debjyoti Bhattacharya , Devon C. Kleeblatt , Antonia Statt , Wesley F. Reinhart

Trajectory prediction module in an autonomous driving system is crucial for the decision-making and safety of the autonomous agent car and its surroundings. This work presents a novel scheme called AiGem (Agent-Interaction Graph Embedding)…

Robotics · Computer Science 2025-03-27 Jilan Samiuddin , Benoit Boulet , Di Wu

Determining the chemical structure for a single molecule on surface from spectroscopic data represents a challenging high-dimensional inverse problem. Tip-enhanced Raman spectroscopy (TERS) enables chemically specific imaging of single…

Chemical Physics · Physics 2026-03-24 Jie Cui , Yao Zhang , Yang Zhang , Yi Luo , Zhen-Chao Dong

Deep learning has demonstrated its strengths in numerous binary analysis tasks, including function boundary detection, binary code search, function prototype inference, value set analysis, etc. When applying deep learning to binary analysis…

Machine Learning · Computer Science 2021-09-15 Xuezixiang Li , Qu Yu , Heng Yin