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Therapeutic development is a costly and high-risk endeavor that is often plagued by high failure rates. To address this, we introduce TxGemma, a suite of efficient, generalist large language models (LLMs) capable of therapeutic property…

Artificial Intelligence · Computer Science 2025-04-09 Eric Wang , Samuel Schmidgall , Paul F. Jaeger , Fan Zhang , Rory Pilgrim , Yossi Matias , Joelle Barral , David Fleet , Shekoofeh Azizi

Large language models (LLMs) have shown remarkable capabilities in various natural language processing tasks, yet they often struggle with maintaining factual accuracy, particularly in knowledge-intensive domains like healthcare. This study…

Computation and Language · Computer Science 2024-11-01 Hieu Tran , Junda Wang , Yujan Ting , Weijing Huang , Terrence Chen

Agentic LLM frameworks promise autonomous behavior via task decomposition, tool use, and iterative planning, but most deployed systems remain brittle. They lack runtime introspection, cannot diagnose their own failure modes, and do not…

Artificial Intelligence · Computer Science 2025-12-10 Christopher Cruz

In our study, we evaluated large language model (LLM) performance on pharmacy licensure-style question-answering tasks and developed an external knowledge integration method to improve accuracy. We benchmarked ten LLMs with varying…

Software issue resolution aims to address real-world issues in software repositories (e.g., bug fixing and efficiency optimization) based on natural language descriptions provided by users, representing a key aspect of software maintenance.…

Software Engineering · Computer Science 2025-12-30 Zhonghao Jiang , David Lo , Zhongxin Liu

Continuous physiological monitoring is central to emergency care, yet deploying trustworthy AI is challenging. While LLMs can translate complex physiological signals into clinical narratives, it is unclear how agentic systems perform…

Machine Learning · Computer Science 2026-03-05 Davide Gabrielli , Paola Velardi , Stefano Faralli , Bardh Prenkaj

Recent breakthroughs in Large Language Models (LLMs) have led to the emergence of agentic AI systems that extend beyond the capabilities of standalone models. By empowering LLMs to perceive external environments, integrate multimodal…

Artificial Intelligence · Computer Science 2025-03-24 Chengkai Huang , Junda Wu , Yu Xia , Zixu Yu , Ruhan Wang , Tong Yu , Ruiyi Zhang , Ryan A. Rossi , Branislav Kveton , Dongruo Zhou , Julian McAuley , Lina Yao

Reliable extraction of structured data from radiology reports using Large Language Models (LLMs) remains challenging, especially for complex, non-English texts like Hebrew. This study introduces an agent-based uncertainty-aware approach to…

Computation and Language · Computer Science 2025-02-05 Hadas Ben-Atya , Naama Gavrielov , Zvi Badash , Gili Focht , Ruth Cytter-Kuint , Talar Hagopian , Dan Turner , Moti Freiman

Powerful autonomous systems, which reason, plan, and converse using and between numerous tools and agents, are made possible by Large Language Models (LLMs), Vision-Language Models (VLMs), and new agentic AI systems, like LangChain and…

Cryptography and Security · Computer Science 2025-12-30 Toqeer Ali Syed , Mishal Ateeq Almutairi , Mahmoud Abdel Moaty

Artificial Intelligence (AI) has demonstrated significant potential in healthcare, particularly in disease diagnosis and treatment planning. Recent progress in Medical Large Vision-Language Models (Med-LVLMs) has opened up new possibilities…

Machine Learning · Computer Science 2025-03-04 Peng Xia , Kangyu Zhu , Haoran Li , Tianze Wang , Weijia Shi , Sheng Wang , Linjun Zhang , James Zou , Huaxiu Yao

We introduce Agentic Reasoning, a framework that enhances large language model (LLM) reasoning by integrating external tool-using agents. Agentic Reasoning dynamically leverages web search, code execution, and structured memory to address…

Artificial Intelligence · Computer Science 2025-07-16 Junde Wu , Jiayuan Zhu , Yuyuan Liu , Min Xu , Yueming Jin

Early identification of cognitive concerns is critical but often hindered by subtle symptom presentation. This study developed and validated a fully automated, multi-agent AI workflow using LLaMA 3 8B to identify cognitive concerns in 3,338…

Retrieval-Augmented Generation (RAG) systems are usually defined by the combination of a generator and a retrieval component that extracts textual context from a knowledge base to answer user queries. However, such basic implementations…

Computation and Language · Computer Science 2026-04-21 Pietro Ferrazzi , Milica Cvjeticanin , Alessio Piraccini , Davide Giannuzzi

The rapid spread of misinformation in the digital era poses significant challenges to public discourse, necessitating robust and scalable fact-checking solutions. Traditional human-led fact-checking methods, while credible, struggle with…

Artificial Intelligence · Computer Science 2025-06-24 Tam Trinh , Manh Nguyen , Truong-Son Hy

The exponential surge in online health information, coupled with its increasing use by non-experts, highlights the pressing need for advanced Health Information Retrieval models that consider not only topical relevance but also the factual…

Information Retrieval · Computer Science 2025-02-10 Rishabh Uapadhyay , Marco Viviani

Large Language Model (LLM) agents represent a promising shift in human-AI interaction, moving beyond passive prompt-response systems to autonomous agents capable of reasoning, planning, and goal-directed action. While LLM agents are…

Computation and Language · Computer Science 2026-02-06 Weiwen Liu , Jiarui Qin , Xu Huang , Xingshan Zeng , Yunjia Xi , Jianghao Lin , Chuhan Wu , Yasheng Wang , Lifeng Shang , Ruiming Tang , Defu Lian , Yong Yu , Weinan Zhang

Motivated by the challenge to improve the adversarial robustness, security, and trust of medical decision making intelligent agents, this study develops a full-link security enhancement framework, which describes "input risk perception -…

Cryptography and Security · Computer Science 2026-05-12 Saisai Hu

Evaluating the clinical correctness and reasoning fidelity of automatically generated medical imaging reports remains a critical yet unresolved challenge. Existing evaluation methods often fail to capture the structured diagnostic logic…

Artificial Intelligence · Computer Science 2026-01-26 Suzhong Fu , Jingqi Dong , Xuan Ding , Rui Sun , Yiming Yang , Shuguang Cui , Zhen Li

Access to the right evidence does not guarantee that large language models (LLMs) will reason with it correctly. This gap between retrieval and reasoning is especially concerning in clinical settings, where outputs must align with…

Artificial Intelligence · Computer Science 2025-11-21 Deepthi Potluri , Aby Mammen Mathew , Jeffrey B DeWitt , Alexander L. Rasgon , Yide Hao , Junyuan Hong , Ying Ding

The versatility of large language models (LLMs) has been explored across various sectors, but their application in healthcare poses challenges, particularly in the domain of pharmaceutical contraindications where accurate and reliable…

Artificial Intelligence · Computer Science 2025-08-11 Byeonghun Bang , Jongsuk Yoon , Dong-Jin Chang , Seho Park , Yong Oh Lee