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Diffusion probabilistic models (DPMs) have become the state-of-the-art in high-quality image generation. However, DPMs have an arbitrary noisy latent space with no interpretable or controllable semantics. Although there has been significant…

Machine Learning · Computer Science 2024-08-27 Aneesh Komanduri , Chen Zhao , Feng Chen , Xintao Wu

Predicting drug-target affinity is fundamental to virtual screening and lead optimization. However, existing deep models often suffer from representation collapse in stringent cold-start regimes, where the scarcity of labels and domain…

Machine Learning · Statistics 2026-03-13 Yining Qian , Pengjie Wang , Yixiao Li , An-Yang Lu , Cheng Tan , Shuang Li , Lijun Liu

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Tengyue Zhang , Ruiwen Ding , Luoting Zhuang , Yuxiao Wu , Erika F. Rodriguez , William Hsu

Explainable artificial intelligence (XAI) has become increasingly important in decision-critical domains such as healthcare, finance, and law. Counterfactual (CF) explanations, a key approach in XAI, provide users with actionable insights…

Artificial Intelligence · Computer Science 2025-07-22 Volkan Bakir , Polat Goktas , Sureyya Akyuz

Diffusion-based data augmentation (DiffDA) has emerged as a promising approach to improving classification performance under data scarcity. However, existing works vary significantly in task configurations, model choices, and experimental…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Zekun Li , Yinghuan Shi , Yang Gao , Dong Xu

Vertebral fractures are a consequence of osteoporosis, with significant health implications for affected patients. Unfortunately, grading their severity using CT exams is hard and subjective, motivating automated grading methods. However,…

Knee osteoarthritis (OA) is one of the most common musculoskeletal disorders and requires early-stage diagnosis. Nowadays, the deep convolutional neural networks have achieved greatly in the computer-aided diagnosis field. However, the…

Image and Video Processing · Electrical Eng. & Systems 2020-10-13 Jiayu Huo , Liping Si , Xi Ouyang , Kai Xuan , Weiwu Yao , Zhong Xue , Qian Wang , Dinggang Shen , Lichi Zhang

Knee Osteoarthritis (KOA), a leading cause of disability worldwide, is challenging to detect early due to subtle radiographic indicators. Diverse, extensive datasets are needed but are challenging to compile because of privacy, data…

Image and Video Processing · Electrical Eng. & Systems 2023-11-13 Fabi Prezja , Leevi Annala , Sampsa Kiiskinen , Suvi Lahtinen , Timo Ojala

Knee osteoarthritis (OA) is a common degenerate joint disorder that affects a large population of elderly people worldwide. Accurate radiographic assessment of knee OA severity plays a critical role in chronic patient management. Current…

Image and Video Processing · Electrical Eng. & Systems 2021-12-20 Kang Zheng , Yirui Wang , Chen-I Hsieh , Le Lu , Jing Xiao , Chang-Fu Kuo , Shun Miao

The integrity of articular cartilage is a crucial aspect in the early diagnosis of osteoarthritis (OA). Many novel MRI techniques have the potential to assess compositional changes of the cartilage extracellular matrix. Among these…

Computer Vision and Pattern Recognition · Computer Science 2019-12-05 Alejandra Duarte , Chaitra V. Hegde , Aakash Kaku , Sreyas Mohan , José G. Raya

Knee osteoarthritis (OA) is the most common musculoskeletal disease in the world. In primary healthcare, knee OA is diagnosed using clinical examination and radiographic assessment. Osteoarthritis Research Society International (OARSI)…

Image and Video Processing · Electrical Eng. & Systems 2019-07-19 Aleksei Tiulpin , Simo Saarakkala

Reinforcement learning control algorithms face significant challenges due to out-of-distribution and inefficient exploration problems. While model-based reinforcement learning enhances the agent's reasoning and planning capabilities by…

Machine Learning · Computer Science 2025-03-19 Sunbowen Lee , Yicheng Gong , Chao Deng

Knee osteoarthritis (KOA) grading based on radiographic images is a critical yet challenging task due to subtle inter-grade differences, annotation uncertainty, and the inherently ordinal nature of disease progression. Conventional deep…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Xiaoyang Li , Runni Zhou

Conventional imaging diagnostics frequently encounter bottlenecks due to manual inspection, which can lead to delays and inconsistencies. Although deep learning offers a pathway to automation and enhanced accuracy, foundational models in…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Aymen Sekhri , Marouane Tliba , Mohamed Amine Kerkouri , Yassine Nasser , Aladine Chetouani , Alessandro Bruno , Rachid Jennane

In current visual model training, models often rely on only limited sufficient causes for their predictions, which makes them sensitive to distribution shifts or the absence of key features. Attribution methods can accurately identify a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Yannan Chen , Ruoyu Chen , Bin Zeng , Wei Wang , Shiming Liu , Qunli Zhang , Zheng Hu , Laiyuan Wang , Yaowei Wang , Xiaochun Cao

The proliferation of synthetic facial imagery has intensified the need for robust Open-World DeepFake Attribution (OW-DFA), which aims to attribute both known and unknown forgeries using labeled data for known types and unlabeled data…

Computer Vision and Pattern Recognition · Computer Science 2025-12-29 Haiyang Zheng , Nan Pu , Wenjing Li , Teng Long , Nicu Sebe , Zhun Zhong

Knee Osteoarthritis (KOA) is a musculoskeletal condition that can cause significant limitations and impairments in daily activities, especially among older individuals. To evaluate the severity of KOA, typically, X-ray images of the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Adarsh Gupta , Japleen Kaur , Tanvi Doshi , Teena Sharma , Nishchal K. Verma , Shantaram Vasikarla

In biomedical engineering, artificial intelligence has become a pivotal tool for enhancing medical diagnostics, particularly in medical image classification tasks such as detecting pneumonia from chest X-rays and breast cancer screening.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Jingsong Xia , Siqi Wang

We introduce a novel semi-supervised Graph Counterfactual Explainer (GCE) methodology, Dynamic GRAph Counterfactual Explainer (DyGRACE). It leverages initial knowledge about the data distribution to search for valid counterfactuals while…

Machine Learning · Computer Science 2023-08-07 Bardh Prenkaj , Mario Villaizan-Vallelado , Tobias Leemann , Gjergji Kasneci

Knee osteoporosis weakens the bone tissue in the knee joint, increasing fracture risk. Early detection through X-ray images enables timely intervention and improved patient outcomes. While some researchers have focused on diagnosing knee…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Ayesha Siddiqua , Rakibul Hasan , Anichur Rahman , Abu Saleh Musa Miah