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Automated segmentation of hard exudates in colour fundus images is a challenge task due to issues of extreme class imbalance and enormous size variation. This paper aims to tackle these issues and proposes a dual-branch network with…

Computer Vision and Pattern Recognition · Computer Science 2021-05-07 Qing Liu , Haotian Liu , Yixiong Liang

Image segmentation is critically important in almost all medical image analysis for automatic interpretations and processing. However, it is often challenging to perform image segmentation due to data imbalance between intra- and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Zhhengyong Huang , Yao Sui

The accuracy of deep learning methods for two foundational tasks in medical image analysis -- detection and segmentation -- can suffer from class imbalance. We propose a `switching loss' function that adaptively shifts the emphasis between…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Deepak Anand , Gaurav Patel , Yaman Dang , Amit Sethi

Data imbalance between common and rare diseases during model training often causes intelligent diagnosis systems to have biased predictions towards common diseases. The state-of-the-art approaches apply a two-stage learning framework to…

Computer Vision and Pattern Recognition · Computer Science 2022-07-15 Chenghua Zeng , Huijuan Lu , Kanghao Chen , Ruixuan Wang , Wei-Shi Zheng

Deep learning-based methods achieved impressive results for the segmentation of medical images. With the development of 3D fully convolutional networks (FCNs), it has become feasible to produce improved results for multi-organ segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-01-19 Chen Shen , Holger R. Roth , Hirohisa Oda , Masahiro Oda , Yuichiro Hayashi , Kazunari Misawa , Kensaku Mori

The Dice score is widely used for binary segmentation due to its robustness to class imbalance. Soft generalisations of the Dice score allow it to be used as a loss function for training convolutional neural networks (CNN). Although CNNs…

Computer Vision and Pattern Recognition · Computer Science 2018-02-27 Lucas Fidon , Wenqi Li , Luis C. Garcia-Peraza-Herrera , Jinendra Ekanayake , Neil Kitchen , Sebastien Ourselin , Tom Vercauteren

Deep neural networks for medical image segmentation often produce overconfident results misaligned with empirical observations. Such miscalibration, challenges their clinical translation. We propose to use marginal L1 average calibration…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Theodore Barfoot , Luis Garcia-Peraza-Herrera , Ben Glocker , Tom Vercauteren

Image segmentation is pivotal in medical image analysis, facilitating clinical diagnosis, treatment planning, and disease evaluation. Deep learning has significantly advanced automatic segmentation methodologies by providing superior…

Image and Video Processing · Electrical Eng. & Systems 2026-01-22 Zhengyong Huang , Ning Jiang , Xingwen Sun , Lihua Zhang , Peng Chen , Jens Domke , Yao Sui

Albeit the Dice loss is one of the dominant loss functions in medical image segmentation, most research omits a closer look at its derivative, i.e. the real motor of the optimization when using gradient descent. In this paper, we highlight…

Computer Vision and Pattern Recognition · Computer Science 2022-11-10 Sofie Tilborghs , Jeroen Bertels , David Robben , Dirk Vandermeulen , Frederik Maes

In many medical imaging and classical computer vision tasks, the Dice score and Jaccard index are used to evaluate the segmentation performance. Despite the existence and great empirical success of metric-sensitive losses, i.e. relaxations…

Image and Video Processing · Electrical Eng. & Systems 2020-10-27 Tom Eelbode , Jeroen Bertels , Maxim Berman , Dirk Vandermeulen , Frederik Maes , Raf Bisschops , Matthew B. Blaschko

The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, resulting in…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Michael Yeung , Leonardo Rundo , Yang Nan , Evis Sala , Carola-Bibiane Schönlieb , Guang Yang

Deep neural networks for medical image segmentation are often overconfident, compromising both reliability and clinical utility. In this work, we propose differentiable formulations of marginal L1 Average Calibration Error (mL1-ACE) as an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Theodore Barfoot , Luis C. Garcia-Peraza-Herrera , Samet Akcay , Ben Glocker , Tom Vercauteren

We study the impact of different loss functions on lesion segmentation from medical images. Although the Cross-Entropy (CE) loss is the most popular option when dealing with natural images, for biomedical image segmentation the soft Dice…

Computer Vision and Pattern Recognition · Computer Science 2022-09-15 Adrian Galdran , Gustavo Carneiro , Miguel Ángel González Ballester

Recently, methods based on Convolutional Neural Networks (CNN) achieved impressive success in semantic segmentation tasks. However, challenges such as the class imbalance and the uncertainty in the pixel-labeling process are not completely…

The realm of medical image diagnosis has advanced significantly with the integration of computer-aided diagnosis and surgical systems. However, challenges persist, particularly in achieving precise image segmentation. While deep learning…

Image and Video Processing · Electrical Eng. & Systems 2023-08-24 Mutyyba Asghar , Ahmad Raza Shahid , Akhtar Jamil , Kiran Aftab , Syed Ather Enam

Deep learning models have gained remarkable performance on a variety of image classification tasks. However, many models suffer from limited performance in clinical or medical settings when data are imbalanced. To address this challenge, we…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Long Gao , Chang Liu , Dooman Arefan , Ashok Panigrahy , Margarita L. Zuley , Shandong Wu

Dynamic contrast-enhanced magnetic resonance imaging (DCE- MRI) is a widely used multi-phase technique routinely used in clinical practice. DCE and similar datasets of dynamic medical data tend to contain redundant information on the…

The Dice score and Jaccard index are commonly used metrics for the evaluation of segmentation tasks in medical imaging. Convolutional neural networks trained for image segmentation tasks are usually optimized for (weighted) cross-entropy.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-09 Jeroen Bertels , Tom Eelbode , Maxim Berman , Dirk Vandermeulen , Frederik Maes , Raf Bisschops , Matthew Blaschko

Semantic segmentation of histopathology images under class imbalance is typically addressed through frequency-based loss reweighting, which implicitly assumes that rare classes are difficult. However, true difficulty also arises from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-16 Lakmali Nadeesha Kumari , Sen-Ching Samson Cheung

This paper seeks to address the dense labeling problems where a significant fraction of the dataset can be pruned without sacrificing much accuracy. We observe that, on standard medical image segmentation benchmarks, the loss gradient…

Computer Vision and Pattern Recognition · Computer Science 2023-08-03 Yongkang He , Mingjin Chen , Zhijing Yang , Yongyi Lu