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This work presents a diffusion transformer framework for data-driven structural topology optimization that combines the accuracy of physics-based methods with the efficiency of generative deep learning. Conventional approaches such as the…

Computational Engineering, Finance, and Science · Computer Science 2026-05-05 Aaron Lutheran , Srijan Das , Alireza Tabarraei

Diffusion models are the standard toolkit for generative modelling of 3D atomic systems. However, for different types of atomic systems -- such as molecules and materials -- the generative processes are usually highly specific to the target…

Generating visual layouts is an essential ingredient of graphic design. The ability to condition layout generation on a partial subset of component attributes is critical to real-world applications that involve user interaction. Recently,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-08 Elad Levi , Eli Brosh , Mykola Mykhailych , Meir Perez

Recent Diffusion Transformers (e.g., DiT) have demonstrated their powerful effectiveness in generating high-quality 2D images. However, it is still being determined whether the Transformer architecture performs equally well in 3D shape…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Shentong Mo , Enze Xie , Ruihang Chu , Lewei Yao , Lanqing Hong , Matthias Nießner , Zhenguo Li

In this work, we empirically study Diffusion Transformers (DiTs) for text-to-image generation, focusing on architectural choices, text-conditioning strategies, and training protocols. We evaluate a range of DiT-based…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Chen Chen , Rui Qian , Wenze Hu , Tsu-Jui Fu , Jialing Tong , Xinze Wang , Lezhi Li , Bowen Zhang , Alex Schwing , Wei Liu , Yinfei Yang

Molecule generation is a very important practical problem, with uses in drug discovery and material design, and AI methods promise to provide useful solutions. However, existing methods for molecule generation focus either on 2D graph…

Machine Learning · Computer Science 2024-02-07 Chenqing Hua , Sitao Luan , Minkai Xu , Rex Ying , Jie Fu , Stefano Ermon , Doina Precup

Recent advances in diffusion transformers (DiTs) have set new standards in image generation, yet remain impractical for on-device deployment due to their high computational and memory costs. In this work, we present an efficient DiT…

Inverse molecular design with diffusion models holds great potential for advancements in material and drug discovery. Despite success in unconditional molecular generation, integrating multiple properties such as synthetic score and gas…

Machine Learning · Computer Science 2024-10-04 Gang Liu , Jiaxin Xu , Tengfei Luo , Meng Jiang

Diffusion Transformers (DiTs) introduce the transformer architecture to diffusion tasks for latent-space image generation. With an isotropic architecture that chains a series of transformer blocks, DiTs demonstrate competitive performance…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Yuchuan Tian , Zhijun Tu , Hanting Chen , Jie Hu , Chao Xu , Yunhe Wang

While generative modeling on time series facilitates more capable and flexible probabilistic forecasting, existing generative time series models do not address the multi-dimensional properties of time series data well. The prevalent…

Machine Learning · Computer Science 2026-02-09 Haoran Zhang , Haixuan Liu , Yong Liu , Yunzhong Qiu , Yuxuan Wang , Jianmin Wang , Mingsheng Long

Diffusion Transformer (DiT), an emerging diffusion model for image generation, has demonstrated superior performance but suffers from substantial computational costs. Our investigations reveal that these costs stem from the static inference…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Wangbo Zhao , Yizeng Han , Jiasheng Tang , Kai Wang , Yibing Song , Gao Huang , Fan Wang , Yang You

Diffusion Transformers (DiTs) have emerged as a leading architecture for text-to-image synthesis, producing high-quality and photorealistic images. However, the quadratic scaling properties of the attention in DiTs hinder image generation…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Philipp Becker , Abhinav Mehrotra , Ruchika Chavhan , Malcolm Chadwick , Luca Morreale , Mehdi Noroozi , Alberto Gil Ramos , Sourav Bhattacharya

Layout generation is a foundation task of graphic design, which requires the integration of visual aesthetics and harmonious expression of content delivery. However, existing methods still face challenges in generating precise and visually…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Yu Li , Yifan Chen , Gongye Liu , Fei Yin , Qingyan Bai , Jie Wu , Hongfa Wang , Ruihang Chu , Yujiu Yang

Diffusion Transformers (DiT) have demonstrated remarkable generative capabilities but remain highly computationally expensive. Previous acceleration methods, such as pruning and distillation, typically rely on a fixed computational…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jiangshan Wang , Zeqiang Lai , Jiarui Chen , Jiayi Guo , Hang Guo , Xiu Li , Xiangyu Yue , Chunchao Guo

Diffusion Transformers (DiTs) with billions of model parameters form the backbone of popular image and video generation models like DALL.E, Stable-Diffusion and SORA. Though these models are necessary in many low-latency applications like…

Computer Vision and Pattern Recognition · Computer Science 2025-02-21 Vignesh Sundaresha

This work introduces MiDi, a novel diffusion model for jointly generating molecular graphs and their corresponding 3D arrangement of atoms. Unlike existing methods that rely on predefined rules to determine molecular bonds based on the 3D…

Machine Learning · Computer Science 2023-06-06 Clement Vignac , Nagham Osman , Laura Toni , Pascal Frossard

The task of deducing three-dimensional molecular configurations from their two-dimensional graph representations holds paramount importance in the fields of computational chemistry and pharmaceutical development. The rapid advancement of…

Biomolecules · Quantitative Biology 2025-01-09 Bobin Yang , Jie Deng , Zhenghan Chen , Ruoxue Wu

Diffusion models are widely recognized for generating high-quality and diverse images, but their poor real-time performance has led to numerous acceleration works, primarily focusing on UNet-based structures. With the more successful…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Pengtao Chen , Mingzhu Shen , Peng Ye , Jianjian Cao , Chongjun Tu , Christos-Savvas Bouganis , Yiren Zhao , Tao Chen

Molecular dynamics (MD) has long been the de facto choice for simulating complex atomistic systems from first principles. Recently deep learning models become a popular way to accelerate MD. Notwithstanding, existing models depend on…

Computational Engineering, Finance, and Science · Computer Science 2023-01-10 Fang Wu , Stan Z. Li

Diffusion models have demonstrated remarkable success in various domains, including molecular generation. However, conditional molecular generation remains a fundamental challenge due to an intrinsic trade-off between targeting specific…

Machine Learning · Computer Science 2024-11-04 Hojung Jung , Youngrok Park , Laura Schmid , Jaehyeong Jo , Dongkyu Lee , Bongsang Kim , Se-Young Yun , Jinwoo Shin
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