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Mechanical ventilation is a critical life support intervention that delivers controlled air and oxygen to a patient's lungs, assisting or replacing spontaneous breathing. While several data-driven approaches have been proposed to optimize…

Machine Learning · Computer Science 2025-01-10 Joo Seung Lee , Malini Mahendra , Anil Aswani

Mechanical ventilation is a key form of life support for patients with pulmonary impairment. Healthcare workers are required to continuously adjust ventilator settings for each patient, a challenging and time consuming task. Hence, it would…

Machine Learning · Computer Science 2022-10-07 Flemming Kondrup , Thomas Jiralerspong , Elaine Lau , Nathan de Lara , Jacob Shkrob , My Duc Tran , Doina Precup , Sumana Basu

Mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory failure (ARF) in the ICU. However, inappropriate ventilator settings could cause ventilator-induced lung injury (VILI). Also, clinicians workload…

Machine Learning · Computer Science 2026-03-13 Hang Yu , Huidong Liu , Qingchen Zhang , William Joy , Kateryna Nikulina , Andreas A. Schuppert , Sina Saffaran , Declan Bates

The management of invasive mechanical ventilation, and the regulation of sedation and analgesia during ventilation, constitutes a major part of the care of patients admitted to intensive care units. Both prolonged dependence on mechanical…

Artificial Intelligence · Computer Science 2017-04-24 Niranjani Prasad , Li-Fang Cheng , Corey Chivers , Michael Draugelis , Barbara E Engelhardt

Mechanical ventilation is one of the most widely used therapies in the ICU. However, despite broad application from anaesthesia to COVID-related life support, many injurious challenges remain. We frame these as a control problem:…

Reinforcement Learning (RL) offers a powerful framework for optimizing dynamic treatment regimes (DTRs). However, clinical RL is fundamentally bottlenecked by reward engineering: the challenge of defining signals that safely and effectively…

Machine Learning · Computer Science 2026-02-05 Qianyi Xu , Gousia Habib , Feng Wu , Yanrui Du , Zhihui Chen , Swapnil Mishra , Dilruk Perera , Mengling Feng

In the intensive care unit, the capability to predict the need for mechanical ventilation (MV) facilitates more timely interventions to improve patient outcomes. Recent works have demonstrated good performance in this task utilizing machine…

Machine Learning · Computer Science 2024-07-24 Anwesh Mohanty , Supreeth P. Shashikumar , Jonathan Y. Lam , Shamim Nemati

Identifying the effects of mechanical ventilation strategies and protocols in critical care requires analyzing data from heterogeneous patient-ventilator systems within the context of the clinical decision-making environment. This research…

Quantitative Methods · Quantitative Biology 2026-01-29 David J. Albers , Tell D. Bennett , Jana de Wiljes , George Hripcsak , Bradford J. Smith , Peter D. Sottile , J. N. Stroh

Patients with severe Coronavirus disease 19 (COVID-19) typically require supplemental oxygen as an essential treatment. We developed a machine learning algorithm, based on a deep Reinforcement Learning (RL), for continuous management of…

Machine Learning · Computer Science 2021-11-09 Hua Zheng , Jiahao Zhu , Wei Xie , Judy Zhong

Vision-Language-Action (VLA) models have emerged as a powerful paradigm for robotic manipulation. However, existing post-training methods face a dilemma between stability and exploration: Supervised Fine-Tuning (SFT) is constrained by…

Robotics · Computer Science 2026-03-17 Jiashun Li , Xiaoyu Shi , Hong Xie , Mingsheng Shang , Yun Lu

This paper demonstrates that continual relearning of control policies using incremental deep reinforcement learning (RL) can improve policy learning for non-stationary processes. We demonstrate this approach for a data-driven 'smart…

Machine Learning · Computer Science 2020-08-06 Avisek Naug , Marcos Quiñones-Grueiro , Gautam Biswas

Medical treatments often involve a sequence of decisions, each informed by previous outcomes. This process closely aligns with reinforcement learning (RL), a framework for optimizing sequential decisions to maximize cumulative rewards under…

Machine Learning · Computer Science 2024-10-15 Ali Shirali , Alexander Schubert , Ahmed Alaa

Mechanical ventilation is critical for managing respiratory failure, but inappropriate ventilator settings can lead to ventilator-induced lung injury (VILI), increasing patient morbidity and mortality. Evaluating the causal impact of…

Methodology · Statistics 2025-07-15 Ziren Jiang , Philip S. Crooke , John J. Marini , Jared D. Huling

Visual-Inertial Odometry (VIO) is a critical component for robust ego-motion estimation, enabling foundational capabilities such as autonomous navigation in robotics and real-time 6-DoF tracking for augmented reality. Existing methods face…

Robotics · Computer Science 2026-03-18 Feiyang Pan , Shenghe Zheng , Chunyan Yin , Guangbin Dou

In offline reinforcement learning (RL) an optimal policy is learned solely from a priori collected observational data. However, in observational data, actions are often confounded by unobserved variables. Instrumental variables (IVs), in…

Machine Learning · Statistics 2024-10-16 Luofeng Liao , Zuyue Fu , Zhuoran Yang , Yixin Wang , Mladen Kolar , Zhaoran Wang

Much attention has been devoted recently to the development of machine learning algorithms with the goal of improving treatment policies in healthcare. Reinforcement learning (RL) is a sub-field within machine learning that is concerned…

Multimodal Large Language Models (MLLMs) pose critical safety challenges, as they are susceptible not only to adversarial attacks such as jailbreaking but also to inadvertently generating harmful content for benign users. While internal…

Machine Learning · Computer Science 2026-03-17 Ming Wen , Kun Yang , Xin Chen , Jingyu Zhang , Dingding Han , Shiwen Cui , Yuedong Xu

Our aim is to establish a framework where reinforcement learning (RL) of optimizing interventions retrospectively allows us a regulatory compliant pathway to prospective clinical testing of the learned policies in a clinical deployment. We…

Machine Learning · Computer Science 2020-03-20 Luchen Li , Ignacio Albert-Smet , Aldo A. Faisal

Visual Odometry (VO) is essential to downstream mobile robotics and augmented/virtual reality tasks. Despite recent advances, existing VO methods still rely on heuristic design choices that require several weeks of hyperparameter tuning by…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Nico Messikommer , Giovanni Cioffi , Mathias Gehrig , Davide Scaramuzza

Vision-Language-Action (VLA) models have demonstrated significant potential for generalist robotic policies; however, they struggle to generalize to long-horizon complex tasks in novel real-world domains due to distribution shifts and the…

Robotics · Computer Science 2026-02-25 Zhian Su , Weijie Kong , Haonan Dong , Huixu Dong
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