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In this work we study the assisted translocation of a polymer across a membrane nanopore, inside which a molecular motor exerts a force fuelled by the hydrolysis of ATP molecules. In our model the motor switches to its active state for a…

Soft Condensed Matter · Physics 2018-03-26 A. Fiasconaro , J. J. Mazo , F. Falo

Self-propelling active matter relies on the conversion of energy from the undirected, nanoscopic scale to directed, macroscopic motion. One of the challenges in the design of synthetic active matter lies in the control of dynamic states, or…

Fluid Dynamics · Physics 2025-03-10 Prashanth Ramesh , Yibo Chen , Petra Räder , Svenja Morsbach , Maziyar Jalaal , Corinna C Maass

Living systems efficiently use chemical fuel to do work, process information, and assemble patterns despite thermal noise. Whether high efficiency arises from general principles or specific fine-tuning is unknown. Here, applying a recent…

Biological Physics · Physics 2022-10-11 Milo M Lin

ATP-driven proton pumps, which are critical to the operation of a cell, maintain cytosolic and organellar pH levels within a narrow functional range. These pumps employ two very different mechanisms: an elaborate rotary mechanism used by…

Subcellular Processes · Quantitative Biology 2017-11-01 Ramu Anandakrishnan , Daniel M. Zuckerman

Long-term biomolecular dynamics are critical for understanding key evolutionary transformations in molecular systems. However, capturing these processes requires extended simulation timescales that often exceed the practical limits of…

Quantitative Methods · Quantitative Biology 2025-07-04 Wenqi Zeng , Lu Zhang , Yuan Yao

Molecular-scale computation is crucial for smart materials and nanoscale devices, yet creating single-molecule systems capable of complex computations remains challenging. We present a theoretical framework for a single-molecule computer…

Statistical Mechanics · Physics 2024-10-01 Zhongmin Zhang , Zhiyue Lu

Biomolecular machines transduce between different forms of energy. These machines make directed progress and increase their speed by consuming free energy, typically in the form of nonequilibrium chemical concentrations. Machine dynamics…

Statistical Mechanics · Physics 2018-10-05 Aidan I Brown , David A Sivak

Living systems at the molecular scale are composed of many constituents with strong and heterogeneous interactions, operating far from equilibrium, and subject to strong fluctuations. These conditions pose significant challenges to…

Statistical Mechanics · Physics 2023-04-11 Emma Lathouwers , Joseph N. E. Lucero , David A. Sivak

We propose a simple theoretical model for a molecular chemical engine that catalyzes a chemical reaction and converts the free energy released by the reaction into mechanical work. Binding and unbinding processes of reactant and product…

Statistical Mechanics · Physics 2018-05-22 Kazuo Sasaki

The dynamics of ultrafast energy transfer to water clusters and to bulk water by a highly intense, sub-cycle THz pulse of duration $\approx$~150~fs is investigated in the context of force-field molecular dynamics simulations. We focus our…

Atomic and Molecular Clusters · Physics 2016-07-11 Pankaj Kr. Mishra , Oriol Vendrell , Robin Santra

Information processing machines at the nanoscales are unavoidably affected by thermal fluctuations. Efficient design requires understanding how nanomachines can operate at minimal energy dissipation. In this letter we focus on mechanical…

Statistical Mechanics · Physics 2015-03-17 Paolo Muratore-Ginanneschi , Kay Schwieger

We present a formalism to study the heat transport and the power developed by the local driving fields on a quantum system coupled to macroscopic reservoirs. We show that, quite generally, two important mechanisms can take place: (i)…

Mesoscale and Nanoscale Physics · Physics 2014-05-29 Liliana Arrachea , Michael Moskalets , Luis Martin-Moreno

We propose a scheme to create and transfer thermal squeezed states and random-phase coherent states in a system of two interacting levitated nanoparticles. In this coupled levitated system, we create a thermal squeezed state of motion in…

Quantum Physics · Physics 2025-03-25 Sandeep Sharma , Seongi Hong , Andrey S. Moskalenko

The design of hydrogels that combine mechanical robustness with dynamic reconfigurability remains a fundamental challenge, as increasing crosslink dissociation rates compromise network integrity. This limitation is addressed through the…

Soft Condensed Matter · Physics 2025-08-28 Pierre Le Bourdonnec , Charafeddine Ferkous , Leo Communal , Luca Cipelletti , Rémi Merindol

Trigger waves are self-regenerating propagating fronts that emerge from the coupling of nonlinear reaction kinetics and diffusion. In cells, trigger waves coordinate large-scale processes such as mitotic entry and stress responses. Although…

Molecular Networks · Quantitative Biology 2026-03-12 Jianwei Li , Kai Meng , Xuewen Shen , Fangting Li

The central dogma of molecular biology is the principal framework for understanding how nucleic acid information is propagated and used by living systems to create complex biomolecules. Here, by integrating the structural and dynamic…

Biological Physics · Physics 2018-10-04 Jihoon Shin , Junghoon Kim , Sung Ha Park , Tai Hwan Ha

In recent literature there has been a lot of interest in the phenomena of noise induced transport in the absence of an average bias occurring in spatially periodic systems far from equilibrium. One of the main motivations in this area is to…

Biological Physics · Physics 2007-05-23 Raishma Krishnan , A. M. Jayannavar

Gradients in temperature and particle concentration fuel many processes in the physical and biological world. In the present work we study a thermodynamic engine powered by anisotropic thermal excitation (that may be due to e.g., a…

Systems and Control · Electrical Eng. & Systems 2023-07-13 Olga Movilla Miangolarra , Amirhossein Taghvaei , Tryphon T. Georgiou

An elementary excitation in an aggregate of coupled particles generates a collective excited state. We show that the dynamics of these excitations can be controlled by applying a transient external potential which modifies the phase of the…

Quantum Physics · Physics 2013-06-14 Ping Xiang , Marina Litinskaya , Evgeny A. Shapiro , Roman V. Krems

Molecular motors belonging to the kinesin and myosin super family hydrolyze ATP by cycling through a sequence of chemical states. These cytoplasmic motors are dimers made up of two linked identical monomeric globular proteins. Fueled by the…

Biological Physics · Physics 2022-12-28 Ryota Takaki , Mauro L. Mugnai , D. Thirumalai