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Predicting protein function from amino acid sequence remains a central challenge in data-scarce (low-$N$) regimes, limiting machine learning-guided protein design when only small amounts of assay-labeled sequence-function data are…

Large Language Models (LLMs) are trained on massive, unstructured corpora, making it unclear which social patterns and biases they absorb and later reproduce. Existing evaluations typically examine outputs or activations, but rarely connect…

Sparse Autoencoders (SAEs) can extract interpretable features from large language models (LLMs) without supervision. However, their effectiveness in downstream steering tasks is limited by the requirement for contrastive datasets or large…

Sparse autoencoders (SAEs) extract human-interpretable features from deep neural networks by transforming their activations into a sparse, higher dimensional latent space, and then reconstructing the activations from these latents.…

Preference learning in large language models relies on reward models as proxies for human judgment. However, these models frequently exhibit preference instability, producing contradictory preference assignments in response to subtle,…

Sparse autoencoders (SAEs) have received considerable recent attention as tools for mechanistic interpretability, showing success at extracting interpretable features even from very large LLMs. However, this research has been largely…

The Linear Representation Hypothesis asserts that the embeddings learned by neural networks can be understood as linear combinations of features corresponding to high-level concepts. Based on this ansatz, sparse autoencoders (SAEs) have…

Sparse Autoencoders (SAEs) have emerged as a predominant tool in mechanistic interpretability, aiming to identify interpretable monosemantic features. However, how does sparse encoding organize the representations of activation vector from…

Adapting foundation models for specific purposes has become a standard approach to build machine learning systems for downstream applications. Yet, it is an open question which mechanisms take place during adaptation. Here we develop a new…

Large Reasoning Models (LRMs) exhibit human-like cognitive reasoning strategies (e.g. backtracking, cross-verification) during reasoning process, which improves their performance on complex tasks. Currently, reasoning strategies are…

Modern LLMs face inference efficiency challenges due to their scale. To address this, many compression methods have been proposed, such as pruning and quantization. However, the effect of compression on a model's interpretability remains…

Sparse linear regression is a central problem in high-dimensional statistics. We study the correlated random design setting, where the covariates are drawn from a multivariate Gaussian $N(0,\Sigma)$, and we seek an estimator with small…

Sparse autoencoders (SAEs) are a promising unsupervised approach for identifying causally relevant and interpretable linear features in a language model's (LM) activations. To be useful for downstream tasks, SAEs need to decompose LM…

Sparse autoencoders (SAEs) are a popular technique for interpreting language model activations, and there is extensive recent work on improving SAE effectiveness. However, most prior work evaluates progress using unsupervised proxy metrics…

Sparse autoencoders (SAEs) are a promising technique for decomposing language model activations into interpretable linear features. However, current SAEs fall short of completely explaining model performance, resulting in "dark matter":…

Deep learning, particularly with the advancement of Large Language Models, has transformed biomolecular modeling, with protein language models such as ESM inspiring emerging RNA language models such as RiNALMo. Recent work has begun…

Radiological services are experiencing unprecedented demand, leading to increased interest in automating radiology report generation. Existing Vision-Language Models (VLMs) suffer from hallucinations, lack interpretability, and require…

Understanding training dynamics and feature evolution is crucial for the mechanistic interpretability of large language models (LLMs). Although sparse autoencoders (SAEs) have been used to identify features within LLMs, a clear picture of…

Scientific archives now contain hundreds of petabytes of data across genomics, ecology, climate, and molecular biology that could reveal undiscovered patterns if systematically analyzed at scale. Large-scale, weakly-supervised datasets in…

Instruction tuning data are often quantity-saturated due to the large volume of data collection and fast model iteration, leaving data selection important but underexplored. Existing quality-driven data selection methods, such as LIMA…