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As advancements in artificial intelligence (AI) propel progress in the life sciences, they may also enable the weaponisation and misuse of biological agents. This article differentiates two classes of AI tools that could pose such…

Computers and Society · Computer Science 2023-12-29 Jonas B. Sandbrink

The potential for rapidly-evolving frontier artificial intelligence (AI) models, especially large language models (LLMs), to facilitate bioterrorism or access to biological weapons has generated significant policy, academic, and public…

To accurately and confidently answer the question 'could an AI model or system increase biorisk', it is necessary to have both a sound theoretical threat model for how AI models or systems could increase biorisk and a robust method for…

The potential for rapidly-evolving frontier artificial intelligence (AI) models, especially large language models (LLMs), to facilitate bioterrorism or access to biological weapons has generated significant policy, academic, and public…

AI leaders and safety reports increasingly warn that advances in model reasoning may enable biological misuse, including by low-expertise users, while major labs describe safeguards as expanding but still evolving rather than settled. This…

Computers and Society · Computer Science 2026-04-24 Michael Richter

AI is undergoing a paradigm shift with the rise of models (e.g., BERT, DALL-E, GPT-3) that are trained on broad data at scale and are adaptable to a wide range of downstream tasks. We call these models foundation models to underscore their…

Machine Learning · Computer Science 2022-07-14 Rishi Bommasani , Drew A. Hudson , Ehsan Adeli , Russ Altman , Simran Arora , Sydney von Arx , Michael S. Bernstein , Jeannette Bohg , Antoine Bosselut , Emma Brunskill , Erik Brynjolfsson , Shyamal Buch , Dallas Card , Rodrigo Castellon , Niladri Chatterji , Annie Chen , Kathleen Creel , Jared Quincy Davis , Dora Demszky , Chris Donahue , Moussa Doumbouya , Esin Durmus , Stefano Ermon , John Etchemendy , Kawin Ethayarajh , Li Fei-Fei , Chelsea Finn , Trevor Gale , Lauren Gillespie , Karan Goel , Noah Goodman , Shelby Grossman , Neel Guha , Tatsunori Hashimoto , Peter Henderson , John Hewitt , Daniel E. Ho , Jenny Hong , Kyle Hsu , Jing Huang , Thomas Icard , Saahil Jain , Dan Jurafsky , Pratyusha Kalluri , Siddharth Karamcheti , Geoff Keeling , Fereshte Khani , Omar Khattab , Pang Wei Koh , Mark Krass , Ranjay Krishna , Rohith Kuditipudi , Ananya Kumar , Faisal Ladhak , Mina Lee , Tony Lee , Jure Leskovec , Isabelle Levent , Xiang Lisa Li , Xuechen Li , Tengyu Ma , Ali Malik , Christopher D. Manning , Suvir Mirchandani , Eric Mitchell , Zanele Munyikwa , Suraj Nair , Avanika Narayan , Deepak Narayanan , Ben Newman , Allen Nie , Juan Carlos Niebles , Hamed Nilforoshan , Julian Nyarko , Giray Ogut , Laurel Orr , Isabel Papadimitriou , Joon Sung Park , Chris Piech , Eva Portelance , Christopher Potts , Aditi Raghunathan , Rob Reich , Hongyu Ren , Frieda Rong , Yusuf Roohani , Camilo Ruiz , Jack Ryan , Christopher Ré , Dorsa Sadigh , Shiori Sagawa , Keshav Santhanam , Andy Shih , Krishnan Srinivasan , Alex Tamkin , Rohan Taori , Armin W. Thomas , Florian Tramèr , Rose E. Wang , William Wang , Bohan Wu , Jiajun Wu , Yuhuai Wu , Sang Michael Xie , Michihiro Yasunaga , Jiaxuan You , Matei Zaharia , Michael Zhang , Tianyi Zhang , Xikun Zhang , Yuhui Zhang , Lucia Zheng , Kaitlyn Zhou , Percy Liang

Today's leading AI models engage in sophisticated behaviour when placed in strategic competition. They spontaneously attempt deception, signaling intentions they do not intend to follow; they demonstrate rich theory of mind, reasoning about…

Artificial Intelligence · Computer Science 2026-02-17 Kenneth Payne

Risk thresholds provide a measure of the level of risk exposure that a society or individual is willing to withstand, ultimately shaping how we determine the safety of technological systems. Against the backdrop of the Cold War, the first…

Computers and Society · Computer Science 2025-04-22 Heidy Khlaaf , Sarah Myers West

If the authors of a recent Stanford report (Bommasani et al., 2021) on the opportunities and risks of "foundation models" are to be believed, these models represent a paradigm shift for AI and for the domains in which they will supposedly…

Computers and Society · Computer Science 2021-10-20 Su Lin Blodgett , Michael Madaio

Large language models (LLMs) such as those embedded in 'chatbots' are accelerating and democratizing research by providing comprehensible information and expertise from many different fields. However, these models may also confer easy…

Computers and Society · Computer Science 2023-06-07 Emily H. Soice , Rafael Rocha , Kimberlee Cordova , Michael Specter , Kevin M. Esvelt

Trustworthy capability evaluations are crucial for ensuring the safety of AI systems, and are becoming a key component of AI regulation. However, the developers of an AI system, or the AI system itself, may have incentives for evaluations…

Artificial Intelligence · Computer Science 2025-02-10 Teun van der Weij , Felix Hofstätter , Ollie Jaffe , Samuel F. Brown , Francis Rhys Ward

Foundation models could eventually introduce several pathways for undermining state security: accidents, inadvertent escalation, unintentional conflict, the proliferation of weapons, and the interference with human diplomacy are just a few…

Recent advancements in generative machine learning have enabled rapid progress in biological design tools (BDTs) such as protein structure and sequence prediction models. The unprecedented predictive accuracy and novel design capabilities…

Computers and Society · Computer Science 2023-12-01 Richard Moulange , Max Langenkamp , Tessa Alexanian , Samuel Curtis , Morgan Livingston

Although general-purpose AI systems offer transformational opportunities in science and industry, they simultaneously raise critical concerns about safety, misuse, and potential loss of control. Despite these risks, methods for assessing…

Computers and Society · Computer Science 2025-12-12 Malcolm Murray , Steve Barrett , Henry Papadatos , Otter Quarks , Matt Smith , Alejandro Tlaie Boria , Chloé Touzet , Siméon Campos

Artificial Intelligence (AI) is revolutionizing scientific research, yet its growing integration into laboratory environments presents critical safety challenges. Large language models (LLMs) and vision language models (VLMs) now assist in…

The trustworthiness of AI applications has been the subject of recent research and is also addressed in the EU's recently adopted AI Regulation. The currently emerging foundation models in the field of text, speech and image processing…

We present this article as a small gesture in an attempt to counter what appears to be exponentially growing hype around Artificial Intelligence (AI) and its capabilities, and the distraction provided by the associated talk of…

Computation and Language · Computer Science 2023-07-12 Michael O'Neill , Mark Connor

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

In recent years, artificial intelligence (AI) and machine learning (ML) are reshaping society's production methods and productivity, and also changing the paradigm of scientific research. Among them, the AI language model represented by…

Networking and Internet Architecture · Computer Science 2023-10-11 Haoxiang Luo , Jian Luo , Athanasios V. Vasilakos

Artificial intelligence's (AI) progress holds great promise in tackling pressing societal concerns such as health and climate. Large Language Models (LLM) and the derived chatbots, like ChatGPT, have highly improved the natural language…

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