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Single-cell RNA sequencing (scRNA-seq) provides high-dimensional profiles of cellular states, enabling data-driven modeling of cellular dynamics over time. In practice, time-resolved scRNA-seq is collected at only a few discrete time points…

Machine Learning · Computer Science 2026-05-22 Siyu Pu , Qingqing Long , Xiaohan Huang , Haotian Chen , Jiajia Wang , Meng Xiao , Xiao Luo , Hengshu Zhu , Yuanchun Zhou , Xuezhi Wang

Diffusion Probabilistic Models (DPMs) suffer from inefficient inference due to their slow sampling and high memory consumption, which limits their applicability to various medical imaging applications. In this work, we propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Fahim Ahmed Zaman , Mathews Jacob , Amanda Chang , Kan Liu , Milan Sonka , Xiaodong Wu

Diffusion models have emerged as powerful generative models for graph generation, yet their use for conditional graph generation remains a fundamental challenge. In particular, guiding diffusion models on graphs under arbitrary reward…

Machine Learning · Computer Science 2025-05-27 Victor M. Tenorio , Nicolas Zilberstein , Santiago Segarra , Antonio G. Marques

Seismic imaging from sparsely acquired data faces challenges such as low image quality, discontinuities, and migration swing artifacts. Existing convolutional neural network (CNN)-based methods struggle with complex feature distributions…

Geophysics · Physics 2024-08-01 Xingchen Shi , Shijun Cheng , Weijian Mao , Wei Ouyang

Computational modeling of single-cell gene expression is crucial for understanding cellular processes, but generating realistic expression profiles remains a major challenge. This difficulty arises from the count nature of gene expression…

The social graphs synthesized by the generative models are increasingly in demand due to data scarcity and concerns over user privacy. One of the key performance criteria for generating social networks is the fidelity to specified…

Social and Information Networks · Computer Science 2023-11-07 Jui-Yi Tsai , Ya-Wen Teng , Ho Chiok Yew , De-Nian Yang , Lydia Y. Chen

The harnessing of machine learning, especially deep generative models, has opened up promising avenues in the field of synthetic DNA sequence generation. Whilst Generative Adversarial Networks (GANs) have gained traction for this…

Machine Learning · Computer Science 2023-12-27 Zehui Li , Yuhao Ni , Tim August B. Huygelen , Akashaditya Das , Guoxuan Xia , Guy-Bart Stan , Yiren Zhao

Detecting anomalies in brain MRI scans using supervised deep learning methods presents challenges due to anatomical diversity and labor-intensive requirement of pixel-level annotations. Generative models like Denoising Diffusion…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Vivek Kumar Trivedi , Bheeshm Sharma , P. Balamurugan

This study introduces a text-conditioned approach to generating drumbeats with Latent Diffusion Models (LDMs). It uses informative conditioning text extracted from training data filenames. By pretraining a text and drumbeat encoder through…

Sound · Computer Science 2024-08-07 Pushkar Jajoria , James McDermott

Grasp generation aims to create complex hand-object interactions with a specified object. While traditional approaches for hand generation have primarily focused on visibility and diversity under scene constraints, they tend to overlook the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Peiming Li , Ziyi Wang , Mengyuan Liu , Hong Liu , Chen Chen

Denoising Diffusion Probabilistic Models (DDPMs) have significantly advanced generative AI, achieving impressive results in high-quality image and data generation. However, enhancing fidelity without compromising semantic content remains a…

Graph generation has emerged as a crucial task in machine learning, with significant challenges in generating graphs that accurately reflect specific properties. Existing methods often fall short in efficiently addressing this need as they…

The simulation of discrete karst networks presents a significant challenge due to the complexity of the physicochemical processes occurring within various geological and hydrogeological contexts over extended periods. This complex interplay…

Machine Learning · Statistics 2025-06-12 Dany Lauzon , Julien Straubhaar , Philippe Renard

This paper introduces the Single-Cell Perturbation Prediction Diffusion Model (scPPDM), the first diffusion-based framework for single-cell drug-response prediction from scRNA-seq data. scPPDM couples two condition channels,…

Quantitative Methods · Quantitative Biology 2025-10-15 Zhaokang Liang , Shuyang Zhuang , Xiaoran Jiao , Weian Mao , Hao Chen , Chunhua Shen

Semantic segmentation has made significant progress in recent years thanks to deep neural networks, but the common objective of generating a single segmentation output that accurately matches the image's content may not be suitable for…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Lukas Zbinden , Lars Doorenbos , Theodoros Pissas , Adrian Thomas Huber , Raphael Sznitman , Pablo Márquez-Neila

Graphs with diverse structural characteristics play a central role in modelling and optimization tasks. The ability to generate different types of graphs that exhibit shared properties is likewise essential for algorithm selection and…

Neural and Evolutionary Computing · Computer Science 2026-03-31 Hendrik Richter , Frank Neumann

Single-image super-resolution (SISR) typically focuses on restoring various degraded low-resolution (LR) images to a single high-resolution (HR) image. However, during SISR tasks, it is often challenging for models to simultaneously…

Image and Video Processing · Electrical Eng. & Systems 2023-11-10 Xin Wang , Jing-Ke Yan , Jing-Ye Cai , Jian-Hua Deng , Qin Qin , Yao Cheng

Recent advancements in diffusion models have demonstrated significant success in unsupervised anomaly segmentation. For anomaly segmentation, these models are first trained on normal data; then, an anomalous image is noised to an…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Mehrdad Moradi , Kamran Paynabar

Graph generation generally aims to create new graphs that closely align with a specific graph distribution. Existing works often implicitly capture this distribution through the optimization of generators, potentially overlooking the…

Machine Learning · Computer Science 2024-07-19 Song Wang , Zhen Tan , Xinyu Zhao , Tianlong Chen , Huan Liu , Jundong Li

Generative models have achieved remarkable success in image, video, and text domains. Inspired by this, researchers have explored utilizing generative models to generate neural network parameters. However, these efforts have been limited by…

Artificial Intelligence · Computer Science 2024-08-05 Xiaolong Jin , Kai Wang , Dongwen Tang , Wangbo Zhao , Yukun Zhou , Junshu Tang , Yang You