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Modern scientific discovery faces growing challenges in integrating vast and heterogeneous knowledge critical to breakthroughs in biomedicine and drug development. Traditional hypothesis-driven research, though effective, is constrained by…

Human-Computer Interaction · Computer Science 2025-07-24 Haoran Jiang , Shaohan Shi , Yunjie Yao , Chang Jiang , Quan Li

There is growing interest in hypothesis generation with large language models (LLMs). However, fundamental questions remain: what makes a good hypothesis, and how can we systematically evaluate methods for hypothesis generation? To address…

Artificial Intelligence · Computer Science 2026-02-12 Haokun Liu , Sicong Huang , Jingyu Hu , Yangqiaoyu Zhou , Chenhao Tan

Hypothetical induction is recognized as the main reasoning type when scientists make observations about the world and try to propose hypotheses to explain those observations. Past research on hypothetical induction is under a constrained…

Computation and Language · Computer Science 2024-06-13 Zonglin Yang , Xinya Du , Junxian Li , Jie Zheng , Soujanya Poria , Erik Cambria

Large language models (LLMs) have demonstrated remarkable capabilities in various scientific domains, from natural language processing to complex problem-solving tasks. Their ability to understand and generate human-like text has opened up…

Computation and Language · Computer Science 2024-11-05 Guangzhi Xiong , Eric Xie , Amir Hassan Shariatmadari , Sikun Guo , Stefan Bekiranov , Aidong Zhang

Large language models (LLMs) are proficient at generating fluent text with minimal task-specific supervision. Yet, their ability to provide well-grounded rationalizations for knowledge-intensive tasks remains under-explored. Such tasks,…

Computation and Language · Computer Science 2024-02-02 Aditi Mishra , Sajjadur Rahman , Hannah Kim , Kushan Mitra , Estevam Hruschka

Large Language Models (LLMs) demonstrate impressive mathematical reasoning abilities, but their solutions frequently contain errors that cannot be automatically checked. Formal theorem proving systems such as Lean 4 offer automated…

Artificial Intelligence · Computer Science 2026-03-18 Sumanth Varambally , Thomas Voice , Yanchao Sun , Zhifeng Chen , Rose Yu , Ke Ye

Large language models (LLMs) have shown potential in assisting scientific research, yet their ability to discover high-quality research hypotheses remains unexamined due to the lack of a dedicated benchmark. To address this gap, we…

Computation and Language · Computer Science 2026-04-21 Yujie Liu , Zonglin Yang , Tong Xie , Jinjie Ni , Ben Gao , Yuqiang Li , Shixiang Tang , Wanli Ouyang , Erik Cambria , Dongzhan Zhou

The ability to derive underlying principles from a handful of observations and then generalize to novel situations -- known as inductive reasoning -- is central to human intelligence. Prior work suggests that language models (LMs) often…

Computation and Language · Computer Science 2024-05-24 Linlu Qiu , Liwei Jiang , Ximing Lu , Melanie Sclar , Valentina Pyatkin , Chandra Bhagavatula , Bailin Wang , Yoon Kim , Yejin Choi , Nouha Dziri , Xiang Ren

Large language models are a form of artificial intelligence systems whose primary knowledge consists of the statistical patterns, semantic relationships, and syntactical structures of language1. Despite their limited forms of "knowledge",…

Artificial Intelligence · Computer Science 2023-10-13 Yizhen Zheng , Huan Yee Koh , Jiaxin Ju , Anh T. N. Nguyen , Lauren T. May , Geoffrey I. Webb , Shirui Pan

Systematic reviews are crucial for synthesizing scientific evidence but remain labor-intensive, especially when extracting detailed methodological information. Large language models (LLMs) offer potential for automating methodological…

Computation and Language · Computer Science 2025-10-14 Wenqing Zhang , Trang Nguyen , Elizabeth A. Stuart , Yiqun T. Chen

Generating novel and creative scientific hypotheses is a cornerstone in achieving Artificial General Intelligence. Large language and reasoning models have the potential to aid in the systematic creation, selection, and validation of…

Computation and Language · Computer Science 2025-04-18 Charles O'Neill , Tirthankar Ghosal , Roberta Răileanu , Mike Walmsley , Thang Bui , Kevin Schawinski , Ioana Ciucă

Large Language Models (LLMs), particularly smaller variants, still struggle with complex reasoning tasks. While inference-time prompting can guide reasoning, existing methods often rely on sequential queries. Ensemble approaches offer a…

Computation and Language · Computer Science 2025-10-28 Gregory Kang Ruey Lau , Wenyang Hu , Diwen Liu , Jizhuo Chen , See-Kiong Ng , Bryan Kian Hsiang Low

Large language models are powerful text processors and reasoners, but are still subject to limitations including outdated knowledge and hallucinations, which necessitates connecting them to the world. Retrieval-augmented large language…

Computation and Language · Computer Science 2023-10-24 Zhihong Shao , Yeyun Gong , Yelong Shen , Minlie Huang , Nan Duan , Weizhu Chen

Small language models (SLMs) often struggle with complex mathematical reasoning due to limited capacity to maintain long chains of intermediate steps and to recover from early errors. We address this challenge by introducing a hint-assisted…

Artificial Intelligence · Computer Science 2026-04-15 Jawad Hossain , Xiangyu Guo , Jiawei Zhou , Chong Liu

As language models accelerate scientific research by automating hypothesis generation and implementation, a new bottleneck emerges: evaluating and filtering hundreds of AI-generated ideas without exhaustive experimentation. We ask whether…

Machine Learning · Computer Science 2026-05-22 Srujan P Mule , Aniketh Garikaparthi , Manasi Patwardhan

When prompted with a few examples and intermediate steps, large language models (LLMs) have demonstrated impressive performance in various reasoning tasks. However, prompting methods that rely on implicit knowledge in an LLM often generate…

Artificial Intelligence · Computer Science 2024-12-23 Zhaocheng Zhu , Yuan Xue , Xinyun Chen , Denny Zhou , Jian Tang , Dale Schuurmans , Hanjun Dai

Recent advances in large language models (LLMs) have made it increasingly difficult to distinguish human-written text from AI-generated content. Many existing detectors train supervised neural classifiers that achieve strong in-distribution…

Computation and Language · Computer Science 2026-05-27 Pingfan Su , Kai Ye , Shijin Gong , Erhan Xu , Jin Zhu , Giulia Livieri , Chengchun Shi

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Large language models (LLMs) have demonstrated impressive capabilities in natural language generation. However, their output quality can be inconsistent, posing challenges for generating natural language from logical forms (LFs). This task…

Computation and Language · Computer Science 2023-09-22 Levon Haroutunian , Zhuang Li , Lucian Galescu , Philip Cohen , Raj Tumuluri , Gholamreza Haffari

Assessing the quality of outputs generated by generative models, such as large language models and vision language models, presents notable challenges. Traditional methods for evaluation typically rely on either human assessments, which are…

Computation and Language · Computer Science 2024-10-10 Yaswanth Narsupalli , Abhranil Chandra , Sreevatsa Muppirala , Manish Gupta , Pawan Goyal