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Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

Machine Learning · Computer Science 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

X-ray computed tomographic infrastructures are medical imaging modalities that rely on the acquisition of rays crossing examined objects while measuring their intensity decrease. Physical measurements are post-processed by mathematical…

Image and Video Processing · Electrical Eng. & Systems 2022-01-25 Attila Juhos

Covariance matrix estimation is a fundamental statistical task in many applications, but the sample covariance matrix is sub-optimal when the sample size is comparable to or less than the number of features. Such high-dimensional settings…

Methodology · Statistics 2022-06-06 Huiqin Xin , Sihai Dave Zhao

Conditional density estimation is a general framework for solving various problems in machine learning. Among existing methods, non-parametric and/or kernel-based methods are often difficult to use on large datasets, while methods based on…

Machine Learning · Statistics 2018-06-06 Hiroaki Sasaki , Aapo Hyvärinen

Segmentation of nuclei regions from histological images is an important task for automated computer-aided analysis of histological images, particularly in the presence of impermissible color variation in the color appearance of stained…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Suman Mahapatra , Pradipta Maji

Scientific imaging often involves long acquisition times to obtain high-quality data, especially when probing complex, heterogeneous systems. However, reducing acquisition time to increase throughput inevitably introduces significant noise…

Artificial Intelligence · Computer Science 2025-05-14 Petrus H. Zwart , Tamas Varga , Odeta Qafoku , James A. Sethian

To segment 4K or 6K ultra high-resolution images needs extra computation consideration in image segmentation. Common strategies, such as down-sampling, patch cropping, and cascade model, cannot address well the balance issue between…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Tiancheng Shen , Yuechen Zhang , Lu Qi , Jason Kuen , Xingyu Xie , Jianlong Wu , Zhe Lin , Jiaya Jia

Clustering samples according to an effective metric and/or vector space representation is a challenging unsupervised learning task with a wide spectrum of applications. Among several clustering algorithms, k-means and its kernelized version…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-10-10 Marco Jacopo Ferrarotti , Sergio Decherchi , Walter Rocchia

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker…

Methodology · Statistics 2025-11-13 Anthony-Alexander Christidis , Stefan Van Aelst , Ruben Zamar

We present a new kernel-based algorithm for modeling evenly distributed multidimensional datasets that does not rely on input space sparsification. The presented method reorganizes the typical single-layer kernel-based model into a deep…

Machine Learning · Computer Science 2020-05-01 Hossein Mohamadipanah , Mahdi Heydari , Girish Chowdhary

We introduce a novel data-driven order reduction method for nonlinear control systems, drawing on recent progress in machine learning and statistical dimensionality reduction. The method rests on the assumption that the nonlinear system…

Optimization and Control · Mathematics 2011-06-15 Jake Bouvrie , Boumediene Hamzi

In some previous works, two of the authors introduced a technique to design high-order numerical methods for one-dimensional balance laws that preserve all their stationary solutions. The basis of these methods is a well-balanced…

Numerical Analysis · Mathematics 2025-05-06 Irene Gómez-Bueno , Manuel Jesús Castro Díaz , Carlos Parés , Giovanni Russo

The Gaussian kernel and its traditional normalizations (e.g., row-stochastic) are popular approaches for assessing similarities between data points. Yet, they can be inaccurate under high-dimensional noise, especially if the noise magnitude…

Statistics Theory · Mathematics 2023-07-12 Boris Landa , Xiuyuan Cheng

Commonly-used clustering algorithms usually find ellipsoidal, spherical or other regular-structured clusters, but are more challenged when the underlying groups lack formal structure or definition. Syncytial clustering is the name that we…

Methodology · Statistics 2020-07-30 Israel Almodóvar-Rivera , Ranjan Maitra

Template matching by normalized cross correlation (NCC) is widely used for finding image correspondences. We improve the robustness of this algorithm by preprocessing images with "siamese" convolutional networks trained to maximize the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-25 Davit Buniatyan , Thomas Macrina , Dodam Ih , Jonathan Zung , H. Sebastian Seung

Through one decade's development, the kernel-based regularization method (KRM) has become a complement to the classical maximum likelihood/prediction error method and an emerging new system identification paradigm. One recent example is its…

Systems and Control · Electrical Eng. & Systems 2024-10-29 Xiaozhu Fang , Tianshi Chen

In this paper, we propose a regularized mixture probabilistic model to cluster matrix data and apply it to brain signals. The approach is able to capture the sparsity (low rank, small/zero values) of the original signals by introducing…

Methodology · Statistics 2018-08-07 Xu Gao , Weining Shen , Hernando Ombao

Estimating the score, i.e., the gradient of log density function, from a set of samples generated by an unknown distribution is a fundamental task in inference and learning of probabilistic models that involve flexible yet intractable…

Machine Learning · Statistics 2020-07-01 Yuhao Zhou , Jiaxin Shi , Jun Zhu

Graph kernels methods are based on an implicit embedding of graphs within a vector space of large dimension. This implicit embedding allows to apply to graphs methods which where until recently solely reserved to numerical data. Within the…

Computer Vision and Pattern Recognition · Computer Science 2008-10-21 François-Xavier Dupé , Luc Brun

Kernel density estimation is a convenient way to estimate the probability density of a distribution given the sample of data points. However, it has certain drawbacks: proper description of the density using narrow kernels needs large data…

Data Analysis, Statistics and Probability · Physics 2015-02-27 Anton Poluektov