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Deep learning, particularly with the advancement of Large Language Models, has transformed biomolecular modeling, with protein language models such as ESM inspiring emerging RNA language models such as RiNALMo. Recent work has begun…

Biomolecules · Quantitative Biology 2026-05-18 Taehan Kim , Sangdae Nam

Causal representation learning has emerged as the center of action in causal machine learning research. In particular, multi-domain datasets present a natural opportunity for showcasing the advantages of causal representation learning over…

Machine Learning · Computer Science 2023-12-12 Kartik Ahuja , Amin Mansouri , Yixin Wang

Variational autoencoders (VAEs) are widely used deep generative models capable of learning unsupervised latent representations of data. Such representations are often difficult to interpret or control. We consider the problem of…

Machine Learning · Computer Science 2018-12-18 Jack Klys , Jake Snell , Richard Zemel

Learning interpretable representations of data remains a central challenge in deep learning. When training a deep generative model, the observed data are often associated with certain categorical labels, and, in parallel with learning to…

Machine Learning · Computer Science 2019-10-01 Yifan Xue , Michael Ding , Xinghua Lu

Biological networks are pivotal in deciphering the complexity and functionality of biological systems. Causal inference, which focuses on determining the directionality and strength of interactions between variables rather than merely…

Molecular Networks · Quantitative Biology 2025-11-05 Hongyang Jiang , Yuezhu Wang , Ke Feng , Chaoyi Yin , Yi Chang , Huiyan Sun

This paper proposes an efficient approach to learning disentangled representations with causal mechanisms based on the difference of conditional probabilities in original and new distributions. We approximate the difference with models'…

Machine Learning · Computer Science 2024-01-03 Yuanpeng Li , Joel Hestness , Mohamed Elhoseiny , Liang Zhao , Kenneth Church

Existing multi-behavior recommendations tend to prioritize performance at the expense of explainability, while current explainable methods suffer from limited generalizability due to their reliance on external information. Neuro-Symbolic…

Artificial Intelligence · Computer Science 2026-01-30 Yuzhe Chen , Jie Cao , Youquan Wang , Haicheng Tao , Darko B. Vukovic , Jia Wu

Trajectory Representation Learning (TRL) is a powerful tool for spatial-temporal data analysis and management. TRL aims to convert complicated raw trajectories into low-dimensional representation vectors, which can be applied to various…

Machine Learning · Computer Science 2024-03-08 Jiawei Jiang , Dayan Pan , Houxing Ren , Xiaohan Jiang , Chao Li , Jingyuan Wang

Soils have potential to mitigate climate change by sequestering carbon from the atmosphere, but the soil carbon cycle remains poorly understood. Scientists have developed process-based models of the soil carbon cycle based on existing…

Machine Learning · Computer Science 2026-01-27 Joshua Fan , Haodi Xu , Feng Tao , Md Nasim , Marc Grimson , Yiqi Luo , Carla P. Gomes

Jointly identifying a mixture of discrete and continuous factors of variability without supervision is a key problem in unraveling complex phenomena. Variational inference has emerged as a promising method to learn interpretable mixture…

Machine Learning · Computer Science 2021-04-14 Yeganeh M. Marghi , Rohan Gala , Uygar Sümbül

Disentangled representations enable models to separate factors of variation that are shared across experimental conditions from those that are condition-specific. This separation is essential in domains such as biomedical data analysis,…

Machine Learning · Computer Science 2025-12-16 Yuli Slavutsky , Ozgur Beker , David Blei , Bianca Dumitrascu

In this thesis, we develop methods to enhance the interpretability of recent representation learning techniques in natural language processing (NLP) while accounting for the unavailability of annotated data. We choose to leverage…

Computation and Language · Computer Science 2023-05-05 Ghazi Felhi

This paper focuses on leveraging deep representation learning (DRL) for speech enhancement (SE). In general, the performance of the deep neural network (DNN) is heavily dependent on the learning of data representation. However, the DRL's…

Audio and Speech Processing · Electrical Eng. & Systems 2023-09-28 Yang Xiang , Jesper Lisby Højvang , Morten Højfeldt Rasmussen , Mads Græsbøll Christensen

Rule-based models, e.g., decision trees, are widely used in scenarios demanding high model interpretability for their transparent inner structures and good model expressivity. However, rule-based models are hard to optimize, especially on…

Machine Learning · Computer Science 2024-01-31 Zhuo Wang , Wei Zhang , Ning Liu , Jianyong Wang

Clinical decision support requires not only correct answers but also clinically valid reasoning. We propose Differential Reasoning Learning (DRL), a framework that improves clinical agents by learning from reasoning discrepancies. From…

Artificial Intelligence · Computer Science 2026-02-11 Jinsong Liu , Yuhang Jiang , Ramayya Krishnan , Rema Padman , Yiye Zhang , Jiang Bian

Cell identification within the H&E slides is an essential prerequisite that can pave the way towards further pathology analyses including tissue classification, cancer grading, and phenotype prediction. However, performing such a task using…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Ramin Nakhli , Amirali Darbandsari , Hossein Farahani , Ali Bashashati

We present VAEL, a neuro-symbolic generative model integrating variational autoencoders (VAE) with the reasoning capabilities of probabilistic logic (L) programming. Besides standard latent subsymbolic variables, our model exploits a…

Programming Languages · Computer Science 2022-05-26 Eleonora Misino , Giuseppe Marra , Emanuele Sansone

Self-supervised learning (SlfSL), aiming at learning feature representations through ingeniously designed pretext tasks without human annotation, has achieved compelling progress in the past few years. Very recently, SlfSL has also been…

Computer Vision and Pattern Recognition · Computer Science 2020-01-10 Hai-Ming Xu , Lingqiao Liu , Dong Gong

The ability to learn disentangled representations that split underlying sources of variation in high dimensional, unstructured data is important for data efficient and robust use of neural networks. While various approaches aiming towards…

Machine Learning · Statistics 2019-05-15 Raphael Suter , Đorđe Miladinović , Bernhard Schölkopf , Stefan Bauer

Generative models have emerged as powerful tools in medical imaging, enabling tasks such as segmentation, anomaly detection, and high-quality synthetic data generation. These models typically rely on learning meaningful latent…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jordi Malé , Juan Fortea , Mateus Rozalem-Aranha , Neus Martínez-Abadías , Xavier Sevillano