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Understanding how generative models represent and transform data is a foundational problem in deep learning interpretability. While mechanistic interpretability of discriminative architectures has yielded substantial insights, relatively…

Machine Learning · Computer Science 2026-04-07 Dip Roy , Rajiv Misra , Sanjay Kumar Singh , Anisha Roy

Estimating direct and indirect causal effects from observational data is crucial to understanding the causal mechanisms and predicting the behaviour under different interventions. Causal mediation analysis is a method that is often used to…

Machine Learning · Computer Science 2023-12-19 Ziqi Xu , Debo Cheng , Jiuyong Li , Jixue Liu , Lin Liu , Ke Wang

Temporal causal representation learning is a powerful tool for uncovering complex patterns in observational studies, which are often represented as low-dimensional time series. However, in many real-world applications, data are…

Machine Learning · Computer Science 2025-07-21 Jianhong Chen , Meng Zhao , Mostafa Reisi Gahrooei , Xubo Yue

Controllable data generation aims to synthesize data by specifying values for target concepts. Achieving this reliably requires modeling the underlying generative factors and their relationships. In real-world scenarios, these factors…

Machine Learning · Computer Science 2025-11-21 Qilong Zhao , Shiyu Wang , Zeeshan Memon , Yang Qiao , Guangji Bai , Bo Pan , Zhaohui Qin , Liang Zhao

Many causal systems such as biological processes in cells can only be observed indirectly via measurements, such as gene expression. Causal representation learning -- the task of correctly mapping low-level observations to latent causal…

Machine Learning · Computer Science 2025-10-31 Elliot Layne , Jason Hartford , Sébastien Lachapelle , Mathieu Blanchette , Dhanya Sridhar

As an important problem in causal inference, we discuss the estimation of treatment effects (TEs). Representing the confounder as a latent variable, we propose Intact-VAE, a new variant of variational autoencoder (VAE), motivated by the…

Machine Learning · Statistics 2022-04-22 Pengzhou Wu , Kenji Fukumizu

Conventional supervised learning methods typically assume i.i.d samples and are found to be sensitive to out-of-distribution (OOD) data. We propose Generative Causal Representation Learning (GCRL) which leverages causality to facilitate…

Machine Learning · Computer Science 2023-04-27 Shayan Shirahmad Gale Bagi , Zahra Gharaee , Oliver Schulte , Mark Crowley

Causal Temporal Representation Learning (Ctrl) methods aim to identify the temporal causal dynamics of complex nonstationary temporal sequences. Despite the success of existing Ctrl methods, they require either directly observing the domain…

Machine Learning · Computer Science 2024-09-06 Xiangchen Song , Zijian Li , Guangyi Chen , Yujia Zheng , Yewen Fan , Xinshuai Dong , Kun Zhang

A major challenge in modern reinforcement learning (RL) is efficient control of dynamical systems from high-dimensional sensory observations. Learning controllable embedding (LCE) is a promising approach that addresses this challenge by…

Machine Learning · Computer Science 2020-06-25 Brandon Cui , Yinlam Chow , Mohammad Ghavamzadeh

In health and social sciences, it is critically important to identify subgroups of the study population where there is notable heterogeneity of treatment effects (HTE) with respect to the population average. Decision trees have been…

Methodology · Statistics 2024-05-28 Falco J. Bargagli-Stoffi , Riccardo Cadei , Kwonsang Lee , Francesca Dominici

Learning Interpretable representation in medical applications is becoming essential for adopting data-driven models into clinical practice. It has been recently shown that learning a disentangled feature representation is important for a…

Machine Learning · Computer Science 2019-04-19 Mhd Hasan Sarhan , Abouzar Eslami , Nassir Navab , Shadi Albarqouni

Using deep latent variable models in causal inference has attracted considerable interest recently, but an essential open question is their ability to yield consistent causal estimates. While they have demonstrated promising results and…

Machine Learning · Computer Science 2022-01-25 Severi Rissanen , Pekka Marttinen

Discovering causal relations among semantic factors is an emergent topic in representation learning. Most causal representation learning (CRL) methods are fully supervised, which is impractical due to costly labeling. To resolve this…

Machine Learning · Computer Science 2023-08-15 Jiageng Zhu , Hanchen Xie , Jianhua Wu , Jiazhi Li , Mahyar Khayatkhoei , Mohamed E. Hussein , Wael AbdAlmageed

Treatment effect estimation, which refers to the estimation of causal effects and aims to measure the strength of the causal relationship, is of great importance in many fields but is a challenging problem in practice. As present,…

Machine Learning · Computer Science 2021-07-20 Zhenyu Guo , Shuai Zheng , Zhizhe Liu , Kun Yan , Zhenfeng Zhu

Optimal computations under uncertainty require an adequate probabilistic representation about beliefs. Deep generative models, and specifically Variational Autoencoders (VAEs), have the potential to meet this demand by building latent…

We propose a novel VAE-based deep auto-encoder model that can learn disentangled latent representations in a fully unsupervised manner, endowed with the ability to identify all meaningful sources of variation and their cardinality. Our…

Machine Learning · Computer Science 2019-02-06 Minyoung Kim , Yuting Wang , Pritish Sahu , Vladimir Pavlovic

Estimating causal effects from observational data is challenging, especially in the presence of latent confounders. Much work has been done on addressing this challenge, but most of the existing research ignores the bias introduced by the…

Machine Learning · Computer Science 2024-08-15 Yang Xie , Ziqi Xu , Debo Cheng , Jiuyong Li , Lin Liu , Yinghao Zhang , Zaiwen Feng

Interpreting critical variables involved in complex biological processes related to survival time can help understand prediction from survival models, evaluate treatment efficacy, and develop new therapies for patients. Currently, the…

Machine Learning · Computer Science 2022-10-03 Xinxing Wu , Chong Peng , Richard Charnigo , Qiang Cheng

Single-cell RNA sequencing (scRNA-seq) enables researchers to analyze gene expression at single-cell level. One important task in scRNA-seq data analysis is unsupervised clustering, which helps identify distinct cell types, laying down the…

Genomics · Quantitative Biology 2023-12-29 Weikang Jiang , Jinxian Wang , Jihong Guan , Shuigeng Zhou

As an important problem in causal inference, we discuss the identification and estimation of treatment effects (TEs) under limited overlap; that is, when subjects with certain features belong to a single treatment group. We use a latent…

Machine Learning · Statistics 2022-04-22 Pengzhou Wu , Kenji Fukumizu