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The automation of scientific discovery represents a critical milestone in Artificial Intelligence (AI) research. However, existing agentic systems for science suffer from two fundamental limitations: rigid, pre-programmed workflows that…

Artificial Intelligence · Computer Science 2025-10-20 Ed Li , Junyu Ren , Xintian Pan , Cat Yan , Chuanhao Li , Dirk Bergemann , Zhuoran Yang

Many scientific applications are I/O intensive and generate or access large data sets, spanning hundreds or thousands of "files." Management, storage, efficient access, and analysis of this data present an extremely challenging task. We…

Distributed, Parallel, and Cluster Computing · Computer Science 2007-05-23 Jaechun No , Rajeev Thakur , Dinesh Kaushik , Lori Freitag , Alok Choudhary

The increasingly collaborative, globalized nature of scientific research combined with the need to share data and the explosion in data volumes present an urgent need for a scientific data management system (SDMS). An SDMS presents a…

Databases · Computer Science 2020-04-09 Dale Stansberry , Suhas Somnath , Jessica Breet , Gregory Shutt , Mallikarjun Shankar

In this work we present the Secure Machine, SeM for short, a CPU architecture extension for secure computing. SeM uses a small amount of in-chip additional hardware that monitors key communication channels inside the CPU chip, and only acts…

Cryptography and Security · Computer Science 2018-03-13 Ofir Shwartz , Yitzhak Birk

Secure multiparty computation (SMC) is a promising technology for privacy-preserving collaborative computation. In the last years several feasibility studies have shown its practical applicability in different fields. However, it is…

Cryptography and Security · Computer Science 2018-08-03 Marcel von Maltitz , Stefan Smarzly , Holger Kinkelin , Georg Carle

Recent advancements in large language model (LLM) agents have significantly accelerated scientific discovery automation, yet concurrently raised critical ethical and safety concerns. To systematically address these challenges, we introduce…

Artificial Intelligence · Computer Science 2025-05-30 Kunlun Zhu , Jiaxun Zhang , Ziheng Qi , Nuoxing Shang , Zijia Liu , Peixuan Han , Yue Su , Haofei Yu , Jiaxuan You

Given the remarkable performance of Large Language Models (LLMs), an important question arises: Can LLMs conduct human-like scientific research and discover new knowledge, and act as an AI scientist? Scientific discovery is an iterative…

Machine Learning · Computer Science 2025-02-24 Tingting Chen , Srinivas Anumasa , Beibei Lin , Vedant Shah , Anirudh Goyal , Dianbo Liu

As scientific research becomes increasingly complex, innovative tools are needed to manage vast data, facilitate interdisciplinary collaboration, and accelerate discovery. Large language models (LLMs) are now evolving into LLM-based…

Artificial Intelligence · Computer Science 2026-02-03 Shuo Ren , Can Xie , Pu Jian , Zhenjiang Ren , Chunlin Leng , Jiajun Zhang

We present S3ML, a secure serving system for machine learning inference in this paper. S3ML runs machine learning models in Intel SGX enclaves to protect users' privacy. S3ML designs a secure key management service to construct flexible…

Machine Learning · Computer Science 2020-10-14 Junming Ma , Chaofan Yu , Aihui Zhou , Bingzhe Wu , Xibin Wu , Xingyu Chen , Xiangqun Chen , Lei Wang , Donggang Cao

Automated scientific discovery with large language models is transforming the research lifecycle from ideation to experimentation, yet existing agents struggle to autonomously process raw data collected from scientific experiments. We…

Artificial Intelligence · Computer Science 2026-04-29 Ke Lin , Yilin Lu , Shreyas Bhat , Xuehang Guo , Junier Oliva , Qingyun Wang

Recent advancements in detector technology have significantly increased the size and complexity of experimental data, and high-performance computing (HPC) provides a path towards more efficient and timely data processing. However, movement…

Networking and Internet Architecture · Computer Science 2024-07-03 Samuel S. Welborn , Bjoern Enders , Chris Harris , Peter Ercius , Deborah J. Bard

The rapid proliferation of scientific knowledge presents a grand challenge: transforming this vast repository of information into an active engine for discovery, especially in high-stakes domains like healthcare. Current AI agents, however,…

Artificial Intelligence · Computer Science 2025-10-14 Yinghao Zhu , Yifan Qi , Zixiang Wang , Lei Gu , Dehao Sui , Haoran Hu , Xichen Zhang , Ziyi He , Junjun He , Liantao Ma , Lequan Yu

Application Programming Interfaces (APIs) are essential tools for social work researchers aiming to harness advanced technologies like Large Language Models (LLMs) and other AI services. This paper demystifies APIs and illustrates how they…

Software Engineering · Computer Science 2024-10-29 Brian E. Perron , Hui Luan , Zia Qi , Bryan G. Victor , Kavin Goyal

When users work with AI agents, they form conscious or subconscious expectations of them. Meeting user expectations is crucial for such agents to engage in successful interactions and teaming. However, users may form expectations of an…

Artificial Intelligence · Computer Science 2025-09-26 Akkamahadevi Hanni , Jonathan Montaño , Yu Zhang

Scientific research is being reshaped by AI systems that move beyond isolated assistance toward longer-horizon workflows spanning literature grounding, hypothesis generation, experimentation, validation, reporting, and revision. This shift…

Despite advances in scientific AI, a coherent framework for Scientific General Intelligence (SGI)-the ability to autonomously conceive, investigate, and reason across scientific domains-remains lacking. We present an operational SGI…

Agentic systems, in which diverse agents cooperate to tackle challenging problems, are exploding in popularity in the AI community. However, existing agentic frameworks take a relatively narrow view of agents, apply a centralized model, and…

Multiagent Systems · Computer Science 2026-01-30 Alok Kamatar , J. Gregory Pauloski , Yadu Babuji , Ryan Chard , Mansi Sakarvadia , Daniel Babnigg , Kyle Chard , Ian Foster

Deep research systems represent an emerging class of agentic information retrieval methods that generate comprehensive and well-supported reports to complex queries. However, most existing frameworks rely on dynamic commercial search APIs,…

Artificial intelligence systems are transforming scientific discovery by accelerating specific research tasks, from protein structure prediction to materials design, yet remain confined to narrow domains requiring substantial human…

Artificial Intelligence · Computer Science 2026-01-30 Gabrielle Wehr , Reuben Rideaux , Amaya J. Fox , David R. Lightfoot , Jason Tangen , Jason B. Mattingley , Shane E. Ehrhardt

There is an increasing need in our society to achieve faster advances in Science to tackle urgent problems, such as climate changes, environmental hazards, sustainable energy systems, pandemics, among others. In certain domains like…