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Artificially generated induced pluripotent stem cells (iPSCs) from somatic cells play an important role for disease modeling and drug screening of neurodegenerative diseases. Astrocytes differentiated from iPSCs are important targets to…
Optical coherence tomography angiography (OCTA) is a novel noninvasive imaging modality for visualization of retinal blood flow in the human retina. Using specific OCTA imaging biomarkers for the identification of pathologies, automated…
Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 x 3-mm OCT scans were acquired…
Purpose: Optical Coherence Tomography Angiography (OCT-A) permits visualization of the changes to the retinal circulation due to diabetic retinopathy (DR), a microvascular complication of diabetes. We demonstrate accurate segmentation of…
Thin-cap fibroatheroma (TCFA) is a prominent risk factor for plaque rupture. Intravascular optical coherence tomography (IVOCT) enables identification of fibrous cap (FC), measurement of FC thicknesses, and assessment of plaque…
Single-Photon Emission Computed Tomography (SPECT) is widely applied for the diagnosis of ischemic heart diseases. Low-dose (LD) SPECT aims to minimize radiation exposure but leads to increased image noise. Limited-angle (LA) SPECT enables…
We develop a connection sensitive attention U-Net(CSAU) for accurate retinal vessel segmentation. This method improves the recent attention U-Net for semantic segmentation with four key improvements: (1) connection sensitive loss that…
Feature Selection (FS) has become the focus of much research on decision support systems areas for which data sets with tremendous number of variables are analyzed. In this paper we present a new method for the diagnosis of Coronary Artery…
Cardiovascular Diseases (CVDs) are the leading cause of death worldwide, taking 17.9 million lives annually. Abdominal Aortic Calcification (AAC) is an established marker for CVD, which can be observed in lateral view Vertebral Fracture…
Cardiac auscultation is the most practiced non-invasive and cost-effective procedure for the early diagnosis of heart diseases. While machine learning based systems can aid in automatically screening patients, the robustness of these…
Accurate segmentation of medical images into anatomically meaningful regions is critical for the extraction of quantitative indices or biomarkers. The common pipeline for segmentation comprises regions of interest detection stage and…
Segmentation is a fundamental task in medical image analysis. However, most existing methods focus on primary region extraction and ignore edge information, which is useful for obtaining accurate segmentation. In this paper, we propose a…
Automated segmentation of intracranial arteries on magnetic resonance angiography (MRA) allows for quantification of cerebrovascular features, which provides tools for understanding aging and pathophysiological adaptations of the…
The precise detection of blood vessels in retinal images is crucial to the early diagnosis of the retinal vascular diseases, e.g., diabetic, hypertensive and solar retinopathies. Existing works often fail in predicting the abnormal areas,…
Pathological area segmentation in cardiac magnetic resonance (MR) images plays a vital role in the clinical diagnosis of cardiovascular diseases. Because of the irregular shape and small area, pathological segmentation has always been a…
Treatment of patients with obstructive coronary artery disease is guided by the functional significance of a coronary artery stenosis. Fractional flow reserve (FFR), measured during invasive coronary angiography (ICA), is considered the…
Automated fetal head segmentation in ultrasound images is critical for accurate biometric measurements in prenatal care. While existing deep learning approaches have achieved a reasonable performance, they struggle with issues like low…
An iris presentation attack detection (IPAD) is essential for securing personal identity is widely used iris recognition systems. However, the existing IPAD algorithms do not generalize well to unseen and cross-domain scenarios because of…
Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Predicting tumors like PDACs (including both classification and segmentation) from medical images by deep learning is becoming a…
In radiotherapy planning, manual contouring is labor-intensive and time-consuming. Accurate and robust automated segmentation models improve the efficiency and treatment outcome. We aim to develop a novel hybrid deep learning approach,…