English
Related papers

Related papers: Equivariant Neural Diffusion for Molecule Generati…

200 papers

Multi-modal image fusion aims to consolidate complementary information from diverse source images into a unified representation. The fused image is expected to preserve fine details and maintain high visual fidelity. While diffusion models…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Xingxin Xu , Bing Cao , DongDong Li , Qinghua Hu , Pengfei Zhu

Deep generative models such as diffusion and flow matching are powerful machine learning tools capable of learning and sampling from high-dimensional distributions. They are particularly useful when the training data appears to be…

High Energy Physics - Phenomenology · Physics 2026-04-30 Zachary Bogorad , Ibrahim Elsharkawy , Yonatan Kahn , Andrew J. Larkoski , Noam Levi

Autoregressive video models offer distinct advantages over bidirectional diffusion models in creating interactive video content and supporting streaming applications with arbitrary duration. In this work, we present Next-Frame Diffusion…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Xinle Cheng , Tianyu He , Jiayi Xu , Junliang Guo , Di He , Jiang Bian

The images produced by diffusion models can attain excellent perceptual quality. However, it is challenging for diffusion models to guarantee distortion, hence the integration of diffusion models and image compression models still needs…

Image and Video Processing · Electrical Eng. & Systems 2024-05-03 Yiyang Ma , Wenhan Yang , Jiaying Liu

Recent advances in self-supervised learning for EEG representation have largely relied on masked reconstruction, where models are trained to recover randomly masked signal segments. While effective at modeling local dependencies, such…

Machine Learning · Computer Science 2026-04-17 Shaocong Wang , Tong Liu , Yihan Li , Ming Li , Kairui Wen , Pei Yang , Wenqi Ji , Minjing Yu , Yong-Jin Liu

We present Graph Neural Diffusion (GRAND) that approaches deep learning on graphs as a continuous diffusion process and treats Graph Neural Networks (GNNs) as discretisations of an underlying PDE. In our model, the layer structure and…

De novo 3D molecule generation is a pivotal task in drug discovery. However, many recent geometric generative models struggle to produce high-quality 3D structures, even if they maintain 2D validity and topological stability. To tackle this…

Machine Learning · Computer Science 2025-05-27 Danny Reidenbach , Filipp Nikitin , Olexandr Isayev , Saee Paliwal

The most advanced diffusion models have recently adopted increasingly deep stacked networks (e.g., U-Net or Transformer) to promote the generative emergence capabilities of vision generation models similar to large language models (LLMs).…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Zhiyuan Ma , Liangliang Zhao , Biqing Qi , Bowen Zhou

Deep neural networks continue to show improved performance with increasing depth, an encouraging trend that implies an explosion in the possible permutations of network architectures and hyperparameters for which there is little intuitive…

Machine Learning · Statistics 2017-09-27 Emmanuel Dufourq , Bruce A. Bassett

The recently developed discrete diffusion models perform extraordinarily well in the text-to-image task, showing significant promise for handling the multi-modality signals. In this work, we harness these traits and present a unified…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Minghui Hu , Chuanxia Zheng , Heliang Zheng , Tat-Jen Cham , Chaoyue Wang , Zuopeng Yang , Dacheng Tao , Ponnuthurai N. Suganthan

Denoising diffusion models have shown great potential in multiple research areas. Existing diffusion-based generative methods on de novo 3D molecule generation face two major challenges. Since majority heavy atoms in molecules allow…

Machine Learning · Computer Science 2024-04-23 Can Xu , Haosen Wang , Weigang Wang , Pengfei Zheng , Hongyang Chen

Representing and reasoning about 3D structures of macromolecules is emerging as a distinct challenge in machine learning. Here, we extend recent work on geometric vector perceptrons and apply equivariant graph neural networks to a wide…

Machine Learning · Computer Science 2021-07-14 Bowen Jing , Stephan Eismann , Pratham N. Soni , Ron O. Dror

We propose an algorithm for learning a conditional generative model of a molecule given a target. Specifically, given a receptor molecule that one wishes to bind to, the conditional model generates candidate ligand molecules that may bind…

Machine Learning · Computer Science 2022-11-10 Eyal Rozenberg , Daniel Freedman

Current generative models, such as autoregressive and diffusion approaches, decompose high-dimensional data distribution learning into a series of simpler subtasks. However, inherent conflicts arise during the joint optimization of these…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Ruixiao Dong , Mengde Xu , Zigang Geng , Li Li , Han Hu , Shuyang Gu

Recent progress on end-to-end neural diarization (EEND) has enabled overlap-aware speaker diarization with a single neural network. This paper proposes to enhance EEND by using multi-channel signals from distributed microphones. We replace…

Audio and Speech Processing · Electrical Eng. & Systems 2022-03-29 Shota Horiguchi , Yuki Takashima , Paola Garcia , Shinji Watanabe , Yohei Kawaguchi

Molecular structure elucidation from spectra is a fundamental challenge in molecular science. Conventional approaches rely heavily on expert interpretation and lack scalability, while retrieval-based machine learning approaches remain…

Machine Learning · Computer Science 2025-11-06 Liang Wang , Yu Rong , Tingyang Xu , Zhenyi Zhong , Zhiyuan Liu , Pengju Wang , Deli Zhao , Qiang Liu , Shu Wu , Liang Wang , Yang Zhang

The generation of 3D molecules requires simultaneously deciding the categorical features~(atom types) and continuous features~(atom coordinates). Deep generative models, especially Diffusion Models (DMs), have demonstrated effectiveness in…

Machine Learning · Computer Science 2023-12-13 Yuxuan Song , Jingjing Gong , Minkai Xu , Ziyao Cao , Yanyan Lan , Stefano Ermon , Hao Zhou , Wei-Ying Ma

We report a series of deep learning models to solve complex forward and inverse design problems in molecular modeling and design. Using both diffusion models inspired by nonequilibrium thermodynamics and attention-based transformer…

Materials Science · Physics 2023-06-21 Rachel K. Luu , Marcin Wysokowski , Markus J. Buehler

Diffusion Models have become a cornerstone of modern generative AI for their exceptional generation quality and controllability. However, their inherent \textit{multi-step iterations} and \textit{complex backbone networks} lead to…

Equivariance of neural networks to transformations helps to improve their performance and reduce generalization error in computer vision tasks, as they apply to datasets presenting symmetries (e.g. scalings, rotations, translations). The…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Mateus Sangalli , Samy Blusseau , Santiago Velasco-Forero , Jesus Angulo