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While pre-trained language models (LMs) have brought great improvements in many NLP tasks, there is increasing attention to explore capabilities of LMs and interpret their predictions. However, existing works usually focus only on a certain…

Computation and Language · Computer Science 2022-07-29 Yaozong Shen , Lijie Wang , Ying Chen , Xinyan Xiao , Jing Liu , Hua Wu

Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to their critical roles in gene regulation and disease mechanisms. However, the complexity and diversity of lncRNA sequences, along with the limited knowledge…

Genomics · Quantitative Biology 2024-11-07 Wei Wang , Zhichao Hou , Xiaorui Liu , Xinxia Peng

Large-scale language models such as DNABert and LOGO aim to learn optimal gene representations and are trained on the entire Human Reference Genome. However, standard tokenization schemes involve a simple sliding window of tokens like…

Computation and Language · Computer Science 2023-10-16 Soumyadeep Roy , Jonas Wallat , Sowmya S Sundaram , Wolfgang Nejdl , Niloy Ganguly

This paper pursues the insight that large language models (LLMs) trained to generate code can vastly improve the effectiveness of mutation operators applied to programs in genetic programming (GP). Because such LLMs benefit from training…

Neural and Evolutionary Computing · Computer Science 2022-06-20 Joel Lehman , Jonathan Gordon , Shawn Jain , Kamal Ndousse , Cathy Yeh , Kenneth O. Stanley

Neglecting non-functional requirements (NFRs) early in software development can lead to critical challenges. Despite their importance, NFRs are often overlooked or difficult to identify, impacting software quality. To support requirements…

Software Engineering · Computer Science 2025-03-20 Jomar Thomas Almonte , Santhosh Anitha Boominathan , Nathalia Nascimento

Vision-Language Models (VLMs), such as recent Qwen and Gemini models, are positioned as general-purpose AI systems capable of reasoning across domains. Yet their capabilities in scientific imaging, especially on unfamiliar and potentially…

Instrumentation and Methods for Astrophysics · Physics 2025-11-13 Mariia Drozdova , Erica Lastufka , Vitaliy Kinakh , Taras Holotyak , Daniel Schaerer , Slava Voloshynovskiy

Language models for biological and chemical sequences enable crucial applications such as drug discovery, protein engineering, and precision medicine. Currently, these language models are predominantly based on Transformer architectures.…

Deep Metric Learning (DML) learns a non-linear semantic embedding from input data that brings similar pairs together while keeping dissimilar data away from each other. To this end, many different methods are proposed in the last decade…

Computer Vision and Pattern Recognition · Computer Science 2023-01-02 Davood Zabihzadeh , Zahraa Alitbi , Seyed Jalaleddin Mousavirad

In this paper, we develop upon the topic of loss function learning, an emergent meta-learning paradigm that aims to learn loss functions that significantly improve the performance of the models trained under them. Specifically, we propose a…

Neural and Evolutionary Computing · Computer Science 2024-03-05 Christian Raymond , Qi Chen , Bing Xue , Mengjie Zhang

Iterative evaluation of LLMs during training is essential to ensure expected capability development, but can be time- and compute-intensive. While NLU tasks, where the model selects from fixed answer choices, are cheap to evaluate,…

Computation and Language · Computer Science 2025-09-17 Viktor Hangya , Fabian Küch , Darina Gold

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

A fundamental characteristic of natural language is the high rate at which speakers produce novel expressions. Because of this novelty, a heavy-tail of rare events accounts for a significant amount of the total probability mass of…

Computation and Language · Computer Science 2022-03-25 Benjamin LeBrun , Alessandro Sordoni , Timothy J. O'Donnell

Explicit structural information has been proven to be encoded by Graph Neural Networks (GNNs), serving as auxiliary knowledge to enhance model capabilities and improve performance in downstream NLP tasks. However, recent studies indicate…

Computation and Language · Computer Science 2025-06-30 Li Zhou , Hao Jiang , Junjie Li , Zefeng Zhao , Feng Jiang , Wenyu Chen , Haizhou Li

Large Language Models (LLMs) are increasingly employed in real-world applications, driving the need to evaluate the trustworthiness of their generated text. To this end, reliable uncertainty estimation is essential. Leading uncertainty…

Machine Learning · Computer Science 2026-04-21 Lukas Aichberger , Kajetan Schweighofer , Sepp Hochreiter

Recent advances in self-supervised models for natural language, vision, and protein sequences have inspired the development of large genomic DNA language models (DNALMs). These models aim to learn generalizable representations of diverse…

Machine Learning · Computer Science 2026-03-25 Aman Patel , Arpita Singhal , Austin Wang , Anusri Pampari , Maya Kasowski , Anshul Kundaje

Large language models (LLMs) are the result of a massive experiment in bottom-up, data-driven reverse engineering of language at scale. Despite their utility in a number of downstream NLP tasks, ample research has shown that LLMs are…

Artificial Intelligence · Computer Science 2024-08-05 Walid S. Saba

Large Language Models (LLMs) have demonstrated great promise in generating code, especially when used inside an evolutionary computation framework to iteratively optimize the generated algorithms. However, in some cases they fail to…

Neural and Evolutionary Computing · Computer Science 2025-03-24 Niki van Stein , Anna V. Kononova , Lars Kotthoff , Thomas Bäck

Large Language Models (LLMs) are recruited in applications that span from clinical assistance and legal support to question answering and education. Their success in specialized tasks has led to the claim that they possess human-like…

Computation and Language · Computer Science 2024-07-10 Vittoria Dentella , Fritz Guenther , Elliot Murphy , Gary Marcus , Evelina Leivada

Despite their impressive ability to generate high-quality and fluent text, generative large language models (LLMs) also produce hallucinations: statements that are misaligned with established world knowledge or provided input context.…

Computation and Language · Computer Science 2025-01-15 Abhilasha Ravichander , Shrusti Ghela , David Wadden , Yejin Choi

Recent advances in large language models (LLMs) have stepped forward the development of multilingual speech and machine translation by its reduced representation errors and incorporated external knowledge. However, both translation tasks…

Computation and Language · Computer Science 2024-05-17 Yuchen Hu , Chen Chen , Chao-Han Huck Yang , Ruizhe Li , Dong Zhang , Zhehuai Chen , Eng Siong Chng