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Consumption of antimicrobial drugs, such as antibiotics, is linked with antimicrobial resistance. Surveillance of antimicrobial drug consumption is therefore an important element in dealing with antimicrobial resistance. Many countries lack…

Information Retrieval · Computer Science 2018-03-12 Niels Dalum Hansen , Kåre Mølbak , Ingemar Cox , Christina Lioma

Antibiotic resistance presents a growing global health threat by diminishing the effectiveness of treatments and allowing once-manageable bacterial infections to persist. This study develops and analyzes an optimization-based mathematical…

Populations and Evolution · Quantitative Biology 2025-09-23 Uzzwal Kumar Mallick , Jobayer Ahmed , Khan Anik Islam , Pulak Kundu

Antibiotic-resistant bacteria has posed a grave threat to public health by causing a number of nosocomial infections in hospitals. Mathematical models have been used to study the transmission of antibiotic-resistant bacteria within a…

Populations and Evolution · Quantitative Biology 2016-10-06 Xiuli Cen , Zhilan Feng , Yiqiang Zheng , Yulin Zhao

Inspired by the natural defence strategies of insect wings and plant leaves, nanostructured surfaces have emerged as a promising tool in various fields, including engineering, biomedical sciences, and materials science to combat bacterial…

Biological Physics · Physics 2025-03-04 Vladimir A. Baulin , Denver P. Linklater , Saulius Juodkazis , Elena P. Ivanova

In this paper, we propose an unsupervised approach for bacterial detection in optical endomicroscopy images. This approach splits each image into a set of overlapping patches and assumes that observed intensities are linear combinations of…

Computer Vision and Pattern Recognition · Computer Science 2019-01-25 Ahmed Karam Eldaly , Yoann Altmann , Ahsan Akram , Antonios Perperidis , Kevin Dhaliwal , Stephen McLaughlin

We propose a mathematical model of Antimicrobial Resistance in the host to predict the failure of two antagonists of bacterial growth: the immune response and a single-antibiotic therapy. After characterising the initial bacterial load that…

Populations and Evolution · Quantitative Biology 2026-01-08 Alejandro Anderson , Rami Katz , Francesca Calà Campana , Giulia Giordano

Clinicians prescribe antibiotics by looking at the patient's health record with an experienced eye. However, the therapy might be rendered futile if the patient has drug resistance. Determining drug resistance requires time-consuming…

Artificial Intelligence · Computer Science 2023-03-09 Honglin Shu , Pei Gao , Lingwei Zhu , Zheng Chen

The large reservoir of antibiotic resistant bacteria in raw and treated water supplies is a matter of public health concern. Currently, the National Antimicrobial Resistance Monitoring Systems, a collaborative effort of the Centers for…

Populations and Evolution · Quantitative Biology 2010-07-09 Bonita Lawrence , Anna Mummert , Charles Somerville

A common shortfall of supervised learning for medical imaging is the greedy need for human annotations, which is often expensive and time-consuming to obtain. This paper proposes a semi-supervised classification method for three kinds of…

Computer Vision and Pattern Recognition · Computer Science 2021-04-15 Yanni Ren , Hangyu Deng , Hao Jiang , Jinglu Hu

Bacteria develop resistance to antibiotics through various mechanisms, with the specific mechanism depending on the drug-bacteria pair. It remains unclear, however, which resistance mechanism best supports favorable treatment outcomes,…

Populations and Evolution · Quantitative Biology 2025-11-06 Ailin Zhang , Shigui Ruan , Xi Huo

The intestinal microbiota plays important roles in digestion and resistance against entero-pathogens. As with other ecosystems, its species composition is resilient against small disturbances but strong perturbations such as antibiotics can…

Quantitative Methods · Quantitative Biology 2015-06-04 Vanni Bucci , Serena Bradde , Giulio Biroli , Joao B. Xavier

Antibiotic resistance constitutes a major health threat. Predicting bacterial causes of infections is key to reducing antibiotic misuse, a leading driver of antibiotic resistance. We train a machine learning algorithm on administrative and…

General Economics · Economics 2019-06-10 Michael Allan Ribers , Hannes Ullrich

Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix.…

Biological Physics · Physics 2017-05-30 Bjorn Birnir , Ana Carpio , Elena Cebrian , Perfecto Vidal

Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with correct antibiotics and slowing down the emergence of antibiotic-resistant bacteria. Here, we report a phenotypic platform that rapidly…

Background: Microbiota have evolved to acclimate themselves to many environments. Humanity is become ever increasingly medicated and many of those medications are antibiotics. Sadly, Microbiota are adapting to medication and with each…

Genomics · Quantitative Biology 2012-09-27 Casey Richardson

The power of photothermal spectroscopic imaging to visualize antimicrobial interaction on the surface of individual bacteria cells has been demonstrated on the model system Bacillus subtilis and vancomycin using mid-infrared photo-induced…

Antibiotic resistance is a major threat to global health. It emerges in multispecies microbial communities under antibiotic exposure. This makes antibiotic spectrum -- a drug's distribution of effects across species -- a potential key…

Populations and Evolution · Quantitative Biology 2026-04-21 Magnus Aspenberg , Erik Andreas Martens , Kristofer Wollein Waldetoft

Bacterial infectious diseases are a major threat to human health. Timely and sensitive pathogenic bacteria detection is crucial in identifying the bacterial contaminations and preventing the spread of infectious diseases. Due to limitations…

Antibiotic resistance, which is a serious healthcare issue, emerges due to uncontrolled and repeated antibiotic use that causes bacteria to mutate and develop resistance to antibiotics. The Antibiotics Time Machine Problem aims to come up…

Optimization and Control · Mathematics 2025-01-22 Deniz Tuncer , Burak Kocuk

The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and presence of antimicrobial on resistance evolution in a…

Populations and Evolution · Quantitative Biology 2020-04-14 Loïc Marrec , Anne-Florence Bitbol