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Despite the wide adoption of Large Language Models (LLM)s, clinical decision support systems face a critical challenge: achieving high predictive accuracy while generating explanations aligned with the predictions. Current approaches suffer…

Artificial Intelligence · Computer Science 2026-05-07 H M Quamran Hasan , Housam Khalifa Bashier , Jiayi Dai , Mi-Young Kim , Randy Goebel

The paradigm shift in large language models (LLMs) from instinctive responses to chain-of-thought (CoT) reasoning has fueled two prevailing assumptions: (1) reasoning capabilities only emerge in sufficiently large models, and (2) such…

Multimodal large language models (MLLMs) have shown great potential in general domains but perform poorly in some specific domains due to a lack of domain-specific data, such as image-text data or vedio-text data. In some specific domains,…

Artificial Intelligence · Computer Science 2025-06-10 Shijie Wang , Yilun Zhang , Zeyu Lai , Dexing Kong

As large language models (LLMs) enter the medical domain, most benchmarks evaluate them on question answering or descriptive reasoning, overlooking quantitative reasoning critical to clinical decision-making. Existing datasets like…

Computation and Language · Computer Science 2025-11-03 Kangkun Mao , Jinru Ding , Jiayuan Chen , Mouxiao Bian , Ruiyao Chen , Xinwei Peng , Sijie Ren , Linyang Li , Jie Xu

Current Large Language Models (LLMs) exhibit significant limitations, notably in structured, interpretable, and verifiable medical reasoning, alongside practical deployment challenges related to computational resources and data privacy.…

Computation and Language · Computer Science 2025-06-06 Boqin Zhuang , Chenxiao Song , Huitong Lu , Jiacheng Qiao , Mingqian Liu , Mingxing Yu , Ping Hong , Rui Li , Xiaoxia Song , Xiangjun Xu , Xu Chen , Yaoyao Ma , Yujie Gao

Multimodal large language models (MLLMs) have demonstrated significant progress in semantic scene understanding and text-image alignment, with reasoning variants enhancing performance on more complex tasks involving mathematics and logic.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Sicheng Feng , Song Wang , Shuyi Ouyang , Lingdong Kong , Zikai Song , Jianke Zhu , Huan Wang , Xinchao Wang

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Large language models (LLMs) face significant challenges in specialized biomedical tasks due to the inherent complexity of medical reasoning and the sensitive nature of clinical data. Existing LLMs often struggle with intricate medical…

Computation and Language · Computer Science 2026-05-12 Zongxian Yang , Jiayu Qian , Kay Chen Tan , Hau-San Wong , Yulong Chen , Haoyu Zhang , Zhi-An Huang

High-quality and carefully curated data is a cornerstone of training medical large language models, as it directly impacts both generalization and robustness to unseen clinical tasks. We investigate strategies for training and data curation…

Artificial Intelligence · Computer Science 2025-12-01 Timothy Ossowski , Sheng Zhang , Qianchu Liu , Guanghui Qin , Reuben Tan , Tristan Naumann , Junjie Hu , Hoifung Poon

Interpretation is critical for disease diagnosis, but existing models struggle to balance predictive accuracy with human-understandable rationales. While large language models (LLMs) offer strong reasoning abilities, their clinical use is…

Computation and Language · Computer Science 2025-07-15 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Yida Xu , Yunya Song , Xian Yang

Large Language Models (LLMs) have advanced Verilog code generation significantly, yet face challenges in data quality, reasoning capabilities, and computational efficiency. This paper presents ReasoningV, a novel model employing a hybrid…

Hardware Architecture · Computer Science 2025-05-02 Haiyan Qin , Zhiwei Xie , Jingjing Li , Liangchen Li , Xiaotong Feng , Junzhan Liu , Wang Kang

Large Language Models have achieved strong performance on reasoning tasks, solving competition-level coding and math problems. However, their scalability is limited by human-labeled datasets and the lack of large-scale, challenging coding…

Computation and Language · Computer Science 2025-10-21 Hanxu Hu , Xingxing Zhang , Jannis Vamvas , Rico Sennrich , Furu Wei

We introduce MedAgentGym, a scalable and interactive training environment designed to enhance coding-based biomedical reasoning capabilities in large language model (LLM) agents. MedAgentGym comprises 72,413 task instances across 129…

Electronic Health Records (EHRs) contain rich yet complex information, and their automated analysis is critical for clinical decision-making. Despite recent advances of large language models (LLMs) in clinical workflows, their ability to…

Computation and Language · Computer Science 2025-11-26 Yusheng Liao , Chaoyi Wu , Junwei Liu , Shuyang Jiang , Pengcheng Qiu , Haowen Wang , Yun Yue , Shuai Zhen , Jian Wang , Qianrui Fan , Jinjie Gu , Ya Zhang , Yanfeng Wang , Yu Wang , Weidi Xie

Medical image segmentation is crucial for clinical diagnosis, yet existing models are limited by their reliance on explicit human instructions and lack the active reasoning capabilities to understand complex clinical questions. While recent…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Yu Huang , Zelin Peng , Yichen Zhao , Piao Yang , Xiaokang Yang , Wei Shen

Large Language Models (LLMs) and Large Multimodal Models (LMMs) demonstrate impressive problem-solving skills in many tasks and domains. However, their ability to reason with complex images in academic domains has not been systematically…

Multimedia · Computer Science 2025-10-01 Chenghao Ma , Haihong E. , Junpeng Ding , Jun Zhang , Ziyan Ma , Huang Qing , Bofei Gao , Liang Chen , Yifan Zhu , Meina Song

Recent advances in reasoning with large language models (LLMs)has shown remarkable reasoning capabilities in domains such as mathematics and coding, yet their application to clinical diagnosis remains underexplored. Here, we introduce…

Computation and Language · Computer Science 2025-04-16 Wuyang Lan , Wenzheng Wang , Changwei Ji , Guoxing Yang , Yongbo Zhang , Xiaohong Liu , Song Wu , Guangyu Wang

Pre-training on large-scale, high-quality datasets is crucial for enhancing the reasoning capabilities of Large Language Models (LLMs), especially in specialized domains such as mathematics. Despite the recognized importance, the Multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Xiaotian Han , Yiren Jian , Xuefeng Hu , Haogeng Liu , Yiqi Wang , Qihang Fan , Yuang Ai , Huaibo Huang , Ran He , Zhenheng Yang , Quanzeng You

Multimodal Large Language Models (MLLMs) have achieved remarkable progress in domains such as visual understanding and mathematical reasoning. However, their application in the medical domain is constrained by two key challenges: (1)…

Computation and Language · Computer Science 2025-10-09 Zeyu Liu , Zhitian Hou , Guanghao Zhu , Zhijie Sang , Congkai Xie , Hongxia Yang

When provided with sufficient explanatory context, smaller Language Models have been shown to exhibit strong reasoning ability on challenging short-answer question-answering tasks where the questions are unseen in training. We evaluate two…

Computation and Language · Computer Science 2023-10-16 Tim Hartill , Diana Benavides-Prado , Michael Witbrock , Patricia J. Riddle