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Designing functional protein sequences that satisfy multiple desired properties is a core research focus of protein engineering. Prior methods struggle with inability or inefficiency when dealing with numerous, often conflicting,…

Biomolecules · Quantitative Biology 2026-05-08 Zitai Kong , Yifan Dong , Yixuan Wu , Zhaokang Liang , Jian Wu , Hongxia Xu

Diffusion Language Models (DLMs) have recently achieved significant success due to their any-order generation capabilities. However, existing inference methods typically rely on local, immediate-step metrics such as confidence or entropy…

Computation and Language · Computer Science 2025-12-03 Kecheng Chen , Ziru Liu , Xijia Tao , Hui Liu , Xinyu Fu , Suiyun Zhang , Dandan Tu , Lingpeng Kong , Rui Liu , Haoliang Li

Diffusion-based generative models have become dominant generators of high-fidelity images and videos but remain limited by their computationally expensive inference procedures. Existing acceleration techniques either require extensive model…

Machine Learning · Computer Science 2025-07-22 Jiaqi Han , Haotian Ye , Puheng Li , Minkai Xu , James Zou , Stefano Ermon

Diffusion-based trajectory planners can synthesize rich, multimodal action sequences for offline reinforcement learning, but their iterative denoising incurs substantial inference-time cost, making closed-loop planning slow under tight…

Robotics · Computer Science 2026-03-17 Gokul Puthumanaillam , Melkior Ornik

Monte Carlo Tree Search (MCTS), most famously used in game-play artificial intelligence (e.g., the game of Go), is a well-known strategy for constructing approximate solutions to sequential decision problems. Its primary innovation is the…

Optimization and Control · Mathematics 2017-04-21 Daniel R. Jiang , Lina Al-Kanj , Warren B. Powell

Addressing decision-making problems using sequence modeling to predict future trajectories shows promising results in recent years. In this paper, we take a step further to leverage the sequence predictive method in wider areas such as…

Robotics · Computer Science 2023-12-07 Mineui Hong , Minjae Kang , Songhwai Oh

In this work we solve the Dynamic Vehicle Routing Problem (DVRP). DVRP is a modification of the Vehicle Routing Problem, in which the clients' requests (cities) number and location might not be known at the beginning of the working day…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Michał Okulewicz , Jacek Mańdziuk

Diffusion models excel in generative tasks, but aligning them with specific objectives while maintaining their versatility remains challenging. Existing fine-tuning methods often suffer from reward over-optimization, while approximate…

Machine Learning · Computer Science 2025-04-18 Sunwoo Kim , Minkyu Kim , Dongmin Park

Discrete diffusion models have become highly effective across various domains. However, real-world applications often require the generative process to adhere to certain constraints. To this end, we propose a Sequential Monte Carlo (SMC)…

Machine Learning · Computer Science 2026-03-17 Zijing Ou , Chinmay Pani , Yingzhen Li

Joint pedestrian trajectory prediction has long grappled with the inherent unpredictability of human behaviors. Recent investigations employing variants of conditional diffusion models in trajectory prediction have exhibited notable…

Robotics · Computer Science 2024-09-05 Haotian Lin , Yixiao Wang , Mingxiao Huo , Chensheng Peng , Zhiyuan Liu , Masayoshi Tomizuka

By framing reinforcement learning as a sequence modeling problem, recent work has enabled the use of generative models, such as diffusion models, for planning. While these models are effective in predicting long-horizon state trajectories…

Discrete cosine transform (DCT) and other Fourier-related transforms have broad applications in scientific computing. However, off-the-shelf high-performance multi-dimensional DCT (MD DCT) libraries are not readily available in parallel…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-10-05 Zixuan Jiang , Jiaqi Gu , David Z. Pan

Autoregressive models (ARMs) are hindered by slow sequential inference. While masked diffusion models (MDMs) offer a parallel alternative, they suffer from critical drawbacks: high computational overhead from precluding Key-Value (KV)…

Computation and Language · Computer Science 2026-03-06 Jia-Nan Li , Jian Guan , Wei Wu , Chongxuan Li

The most widely used methods for toolpath planning in fused deposition 3D printing slice the input model into successive 2D layers in order to construct the toolpath. Unfortunately slicing-based methods can incur a substantial amount of…

Robotics · Computer Science 2020-02-06 Chanyeol Yoo , Samuel Lensgraf , Robert Fitch , Lee M. Clemon , Ramgopal Mettu

Diffusion models have emerged as the mainstream approach for visual generation. However, these models typically suffer from sample inefficiency and high training costs. Consequently, methods for efficient finetuning, inference and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Felix Krause , Timy Phan , Ming Gui , Stefan Andreas Baumann , Vincent Tao Hu , Björn Ommer

Guided diffusion-model generation is a promising direction for customizing the generation process of a pre-trained diffusion model to address specific downstream tasks. Existing guided diffusion models either rely on training the guidance…

Machine Learning · Computer Science 2025-04-01 Kim Yong Tan , Yueming Lyu , Ivor Tsang , Yew-Soon Ong

Diffusion is commonly used as a ranking or re-ranking method in retrieval tasks to achieve higher retrieval performance, and has attracted lots of attention in recent years. A downside to diffusion is that it performs slowly in comparison…

Computer Vision and Pattern Recognition · Computer Science 2019-01-07 Fan Yang , Ryota Hinami , Yusuke Matsui , Steven Ly , Shin'ichi Satoh

We study how to efficiently combine formal methods, Monte Carlo Tree Search (MCTS), and deep learning in order to produce high-quality receding horizon policies in large Markov Decision processes (MDPs). In particular, we use model-checking…

Artificial Intelligence · Computer Science 2023-08-16 Debraj Chakraborty , Damien Busatto-Gaston , Jean-François Raskin , Guillermo A. Pérez

Diffusion Models (DMs) have demonstrated state-of-the-art performance in content generation without requiring adversarial training. These models are trained using a two-step process. First, a forward - diffusion - process gradually adds…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Anwaar Ulhaq , Naveed Akhtar

Continuous transportation of material in the mining industry is achieved by the dispatch of autonomous haul-trucks with discrete haulage capacities. Recently, Monte Carlo Tree Search (MCTS) was successfully deployed in tackling challenges…

Artificial Intelligence · Computer Science 2024-07-24 Milan Tomy , Konstantin M. Seiler , Andrew J. Hill