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Motivated by applications in trajectory inference and particle tracking, we introduce Smooth Schr\"odinger Bridges. Our proposal generalizes prior work by allowing the reference process in the Schr\"odinger Bridge problem to be a smooth…

Machine Learning · Statistics 2025-03-04 Wanli Hong , Yuliang Shi , Jonathan Niles-Weed

Single-cell RNA sequencing (scRNA-seq) provides high-dimensional profiles of cellular states, enabling data-driven modeling of cellular dynamics over time. In practice, time-resolved scRNA-seq is collected at only a few discrete time points…

Machine Learning · Computer Science 2026-05-22 Siyu Pu , Qingqing Long , Xiaohan Huang , Haotian Chen , Jiajia Wang , Meng Xiao , Xiao Luo , Hengshu Zhu , Yuanchun Zhou , Xuezhi Wang

Generative artificial intelligence (AI) has made unprecedented advances in vision language models over the past two years. During the generative process, new samples (images) are generated from an unknown high-dimensional distribution.…

Graphics · Computer Science 2025-10-13 Gurprit Singh , Wenzel Jakob

We introduce Latent Space Distribution Matching (LSDM), a novel framework for semi-supervised generative modeling of conditional distributions. LSDM operates in two stages: (i) learning a low-dimensional latent space from both paired and…

Machine Learning · Statistics 2026-03-05 Kwong Yu Chong , Long Feng

Molecular Dynamics (MD) is crucial in various fields such as materials science, chemistry, and pharmacology to name a few. Conventional MD software struggles with the balance between time cost and prediction accuracy, which restricts its…

Chemical Physics · Physics 2024-12-05 Ziyang Yu , Wenbing Huang , Yang Liu

Score-based diffusion models are frequently employed as structural priors in inverse problems. However, their iterative denoising process, initiated from Gaussian noise, often results in slow inference speeds. The Image-to-Image…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Yuang Wang , Pengfei Jin , Siyeop Yoon , Matthew Tivnan , Quanzheng Li , Li Zhang , Dufan Wu

In this paper, we study the Schr\"odinger Bridge Problem (SBP), which is central to entropic optimal transport. For general reference processes and begin--endpoint distributions, we propose a forward-reverse iterative Monte Carlo procedure…

Machine Learning · Statistics 2025-07-02 Denis Belomestny , John. Schoenmakers

Learning discrete neural samplers is challenging due to the lack of gradients and combinatorial complexity. While stochastic optimal control (SOC) and Schr\"odinger bridge (SB) provide principled solutions, efficient SOC solvers like…

With growing demand for interpretability in deep learning, especially in high stakes domains, Concept Bottleneck Models (CBMs) address this by inserting human understandable concepts into the prediction pipeline, but they are generally…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Jiakai Lin , Jinchang Zhang , Guoyu Lu

A central goal in systems biology and drug discovery is to predict the transcriptional response of cells to perturbations. This task is challenging due to the noisy and sparse nature of single-cell measurements, as well as the fact that…

Quantitative Methods · Quantitative Biology 2026-02-10 Chenglei Yu , Chuanrui Wang , Bangyan Liao , Tailin Wu

This study employs a neural network that represents the solution to a Schr\"odinger bridge problem to perform super-resolution of 2-m temperature in an urban area. Schr\"odinger bridges generally describe transformations between two data…

Atmospheric and Oceanic Physics · Physics 2025-12-15 Yuki Yasuda , Ryo Onishi

Diffusion Bridge and Flow Matching have both demonstrated compelling empirical performance in transformation between arbitrary distributions. However, there remains confusion about which approach is generally preferable, and the substantial…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Kaizhen Zhu , Mokai Pan , Zhechuan Yu , Jingya Wang , Jingyi Yu , Ye Shi

The design of mean and variance schedules for the perturbed signal is a fundamental challenge in generative models. While score-based and Schr\"odinger bridge-based models require careful selection of the stochastic differential equation to…

Sound · Computer Science 2025-09-10 Taihui Wang , Rilin Chen , Tong Lei , Andong Li , Jinzheng Zhao , Meng Yu , Dong Yu

A paradigm put forth by E. Schr\"odinger in 1931/32, known as Schr\"odinger bridges, represents a formalism to pose and solve control and estimation problems seeking a perturbation from an initial control schedule (in the case of control),…

Optimization and Control · Mathematics 2023-07-12 Yongxin Chen , Tryphon T. Georgiou , Michele Pavon

Sequential probabilistic inference from streaming observations requires modeling distributions over future trajectories as new observations arrive. Although diffusion and flow-matching models are effective at capturing high-dimensional,…

Machine Learning · Computer Science 2026-05-15 Yinan Huang , Hans Hao-Hsun Hsu , Junran Wang , Bo Dai , Pan Li

Transportation on graphs is a fundamental challenge across many domains, where decisions must respect topological and operational constraints. Despite the need for actionable policies, existing graph-transport methods lack this…

Machine Learning · Computer Science 2026-02-05 Panagiotis Theodoropoulos , Juno Nam , Evangelos Theodorou , Jaemoo Choi

Many real-world prediction tasks, particularly those involving entities such as customers or patients, involve both {sequential} and {relational} data. Each entity maintains its own sequence of events while simultaneously engaging in…

Machine Learning · Computer Science 2026-04-03 Yuen Chen , Yulun Wu , Samuel Sharpe , Igor Melnyk , Nam H. Nguyen , Furong Huang , C. Bayan Bruss , Rizal Fathony

Accurately understanding the propagation environment is a fundamental challenge in site-specific beamforming (SSBF). This paper proposes a novel generative SSBF (GenSSBF) solution, which represents a paradigm shift from conventional…

Signal Processing · Electrical Eng. & Systems 2026-01-06 Zihao Zhou , Zhaolin Wang , Yuanwei Liu

Flow and bridge matching are a novel class of processes which encompass diffusion models. One of the main aspect of their increased flexibility is that these models can interpolate between arbitrary data distributions i.e. they generalize…

Machine Learning · Computer Science 2023-11-14 Valentin De Bortoli , Guan-Horng Liu , Tianrong Chen , Evangelos A. Theodorou , Weilie Nie

Visual traversability estimation is critical for autonomous navigation, but existing VLM-based methods rely on hand-crafted prompts, generalize poorly across embodiments, and output only traversability maps, leaving trajectory generation to…