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We develop diffusion-based samplers for target distributions known up to a normalising constant. To this end, we rely on the well-known diffusion path that smoothly interpolates between a simple base distribution and the target, popularised…

Polymer chains dissolved in a solvent take random conformations due to large internal degrees of freedom and are characterized geometrically by their average shape and size. The diffusive dynamics of such large macromolecules play an…

Soft Condensed Matter · Physics 2023-07-11 Prabeen Kumar Pattnayak , Aloke Kumar , Gaurav Tomar

Single-file diffusion refers to the motion in narrow channels of particles which cannot bypass each other. These strong correlations between particles lead to tracer subdiffusion, which has been observed in contexts as varied as transport…

Statistical Mechanics · Physics 2021-12-08 Alexis Poncet , Aurélien Grabsch , Pierre Illien , Olivier Bénichou

Anomalous diffusion has been widely observed by single particle tracking microscopy in complex systems such as biological cells. The resulting time series are usually evaluated in terms of time averages. Often anomalous diffusion is…

Statistical Mechanics · Physics 2017-09-13 Stas Burov , Jae-Hyung Jeon , Ralf Metzler , Eli Barkai

Slow dynamics in a fluid are studied in one of the most basic systems possible: polydisperse hard spheres. Monodisperse hard spheres cannot be studied as the slow down in dynamics as the density is increased is preempted by crystallisation.…

Soft Condensed Matter · Physics 2009-10-31 Richard P. Sear

30% of the DNA in E. coli bacteria is covered by proteins. Such high degree of crowding affect the dynamics of generic biological processes (e.g. gene regulation, DNA repair, protein diffusion etc.) in ways that are not yet fully…

Statistical Mechanics · Physics 2015-06-23 Sebastian Ahlberg , Tobias Ambjörnsson , Ludvig Lizana

Several recent experiments, including our own in the fission yeast, S. pombe, have characterized the motions of gene loci within living nuclei by measuring the locus position over time, then proceeding to obtain the statistical properties…

Biological Physics · Physics 2021-03-17 Mary Lou P Bailey , Hao Yan , Ivan Surovtsev , Jessica F Williams , Megan C King , Simon G J Mochrie

We introduce a probabilistic model for protein sliding motion along DNA during the search of a target sequence. The model accounts for possible effects due to sequence-dependent interaction between the nonspecific DNA and the protein. As an…

Biological Physics · Physics 2007-05-23 Maria Barbi , Christophe Place , Vladislav Popkov , Mario Salerno

The transport of biomolecules across a cell membrane is an important phenomena that plays a pivotal role in the functioning of biological cells. In this paper, we investigate such processes by modeling the translocation of polymers through…

Soft Condensed Matter · Physics 2022-11-01 Andri Sharma

Diffusion of chemicals or tracer molecules through complex systems containing irregularly shaped channels is important in many applications. Most theoretical studies based on the famed Fick-Jacobs equation focus on the idealised case of…

Statistical Mechanics · Physics 2014-12-24 Max Bauer , Aljaz Godec , Ralf Metzler

Diffusion coefficient measurements are important for many biological and material investigations, such as particle dynamics, kinetics, and size determinations. Amongst current measurement methods, single particle tracking (SPT) offers the…

Biomolecules · Quantitative Biology 2011-07-12 Shannon Kian Zareh , Michael C. DeSantis , Jonathan Kessler , Je-Luen Li , Y. M. Wang

We address the now classical problem of a diffusion process that crosses over from a ballistic behavior at short times to a fractional diffusion (sub- or super-diffusion) at longer times. Using the standard non-Markovian diffusion equation…

Statistical Mechanics · Physics 2015-05-14 Valery Ilyin , Itamar Procaccia , Anatoly Zagorodny

There is now a certain consensus that Transcription Factors (TFs) reach their target sites, where they regulate gene transcription, via a mechanism dubbed facilitated diffusion (FD). In FD, the TF cycles between events of 3D-diffusion in…

Biomolecules · Quantitative Biology 2015-06-18 Carlo Guardiani , Massimo Cencini , Fabio Cecconi

We investigate the single-file dynamics of a tagged particle in a system consisting of N hardcore interacting particles (the particles cannot pass each other) which are diffusing in a one-dimensional system where the particles have…

Statistical Mechanics · Physics 2009-11-13 Tobias Ambjornsson , Ludvig Lizana , Michael A. Lomholt , Robert J. Silbey

We analyze a simple model of deterministic diffusion. The model consists of a one-dimensional periodic array of scatterers in which point particles move from cell to cell as defined by a piecewise linear map. The microscopic chaotic…

chao-dyn · Physics 2009-10-31 R. Klages , J. R. Dorfman

The translocation dynamics of a polymer chain through a nanopore in the absence of an external driving force is analyzed by means of scaling arguments, fractional calculus, and computer simulations. The problem at hand is mapped on a one…

Soft Condensed Matter · Physics 2007-07-29 J. L. A. Dubbeldam , A. Milchev , V. G. Rostiashvili , T. A. Vilgis

Using Monte Carlo simulations, we systematically investigate the effect of particle size distribution on the phase behaviour of polydisperse hard disks. Compared with the commonly used Gaussian-like polydisperse hard disks [Commun. Phys. 2,…

Soft Condensed Matter · Physics 2020-11-04 Pablo Sampedro Ruiz , Ran Ni

Evaluating the completion time of a random algorithm or a running stochastic process is a valuable tip not only from a purely theoretical, but also pragmatic point of view. In the formal sense, this kind of a task is specified in terms of…

Statistical Mechanics · Physics 2022-11-24 Przemyslaw Chelminiak

The experimental literature on the motion of mesoscopic probe particles through polymer solutions is systematically reviewed. The primary focus is the study of diffusive motion of small probe particles. Comparison is made with measurements…

Soft Condensed Matter · Physics 2007-05-23 George D. J. Phillies

We investigate the long-time evolution of branching diffusion processes (starting with a single particle) in inhomogeneous media. The qualitative behavior of the processes depends on the intensity of the branching. We analyze the…

Probability · Mathematics 2012-07-03 Leonid Koralov , Stanislav Molchanov
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