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Optical absorption measurements characterize a wide variety of systems from atomic gases to \emph{in-vivo} diagnostics of living organisms. Here we study the potential of non-classical techniques to reduce statistical noise below the…

Quantitative phase imaging (QPI) is a label-free technique providing both morphology and quantitative biophysical information in biomedicine. However, applying such a powerful technique to in vivo pathological diagnosis remains challenging.…

The ability to perform high-precision optical measurements is paramount to science and engineering. Laser interferometry enables interaction-free sensing with a precision ultimately limited by shot noise. Quantum optical sensors can surpass…

The biomechanical properties of cells and tissues play an important role in our fundamental understanding of the structures and functions of biological systems at both the cellular and subcellular levels. Recently, Brillouin microscopy,…

The quantum noise of light fundamentally limits optical phase sensors. A semiclassical picture attributes this noise to the random arrival time of photons from a coherent light source such as a laser. An engineered source of squeezed states…

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…

We report both sub-diffraction-limited quantum metrology and quantum enhanced spatial resolution for the first time in a biological context. Nanoparticles are tracked with quantum correlated light as they diffuse through an extended region…

High-precision optical phase stabilization in quantum networks is fundamentally constrained by the strict photon-flux and duty-cycle limits required to avoid disturbing fragile quantum states. This challenge becomes especially critical when…

Quantum physics has brought enhanced capability in various sensing applications. Despite challenges from noise and loss in the radio-frequency (RF) domain, [Phys. Rev. Lett. 124, 150502 (2020)] demonstrates a route for enhanced RF-receiver…

Quantum Physics · Physics 2025-03-06 Haowei Shi , Christopher M. Jones , Mengjie Yu , Zheshen Zhang , Quntao Zhuang

Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but lacks chemical sensitivity limiting its application to…

Optics · Physics 2019-09-04 Miu Tamamitsu , Keiichiro Toda , Ryoichi Horisaki , Takuro Ideguchi

Far-field optical imaging inevitably involves low-pass spatial filtering, limiting the resolution. Moreover, conventional imaging suppresses high spatial frequency components close to the cutoff, making them invisible under noise,…

Quantum Physics · Physics 2026-05-08 Li Gong , Aonan Zhang , Madhura Ghosh Dastidar , Alexander Duplinskii , A. I. Lvovsky

Nonlinear optical microscopy techniques have emerged as a set of successful tools for biological imaging. Stimulated emission microscopy belongs to a small subset of pump-probe techniques which can image non-fluorescent samples without…

In the effort to aid cytologic diagnostics by establishing automatic single cell screening using high throughput digital holographic microscopy for clinical studies thousands of images and millions of cells are captured. The bottleneck lies…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Julia Sistermanns , Ellen Emken , Gregor Weirich , Oliver Hayden , Wolfgang Utschick

Quantitative phase microscopy (QPM), a technique combining phase imaging and microscopy, enables visualization of the 3D topography in reflective samples, as well as the inner structure or refractive index distribution of transparent and…

Optics · Physics 2025-01-17 Vicente Mico , Juanjuan Zheng , Javier Garcia , Zeev Zalevsky , Peng Gao

At the fundamental level, quantum communication is ultimately limited by noise. For instance, quantum signals cannot be amplified without the introduction of noise in the amplified states. Furthermore, photon loss reduces the…

Quantum imaging is an ever expanding research field, in which the aim is to exploit the quantum nature of light to enhance image reconstruction capabilities. Despite a number of successful demonstrations for quantum imaging, quantum…

With the rapid development of microwave photonics, which has expanded to numerous applications of commercial importance, eliminating the emerging bottlenecks becomes of vital importance. For example, as the main branch of microwave…

Quantum Physics · Physics 2022-01-31 Yaqing Jin , Ye Yang , Huibo Hong , Xiao Xiang , Runai Quan , Tao Liu , Shougang Zhang , Ninghua Zhu , Ming Li , Ruifang Dong

The ultimate sensitivity of optical measurements is a key element of many recent works. Classically, it is mainly limited by the shot noise limit. However, a measurement setup that incorporates quantum mechanical principles can surpass the…

Quantum Physics · Physics 2013-11-13 L. Cohen , D. Istrati , L. Dovrat , H. S. Eisenberg

For more than a century, the diffraction limit has defined the resolution achievable by passive optical imaging systems. Although some resolution improvement can be gained through classical data processing of the image, it is limited by the…

Quantum Physics · Physics 2026-05-12 A. I. Lvovsky , Michael R. Grace , Saikat Guha , Mankei Tsang , Gerardo Adesso , Nicolas Treps

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. Despite significant advances in fast multiplexed imaging sensors and deep-learning-based inverse…