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The vast amount of health data has been continuously collected for each patient, providing opportunities to support diverse healthcare predictive tasks such as seizure detection and hospitalization prediction. Existing models are mostly…

Machine Learning · Computer Science 2023-02-16 Chaoqi Yang , M. Brandon Westover , Jimeng Sun

Developing predictive models that perform reliably across diverse patient populations and heterogeneous environments is a core aim of medical research. However, generalization is only possible if the learned model is robust to statistical…

When domains, which represent underlying data distributions, vary during training and testing processes, deep neural networks suffer a drop in their performance. Domain generalization allows improvements in the generalization performance…

Computer Vision and Pattern Recognition · Computer Science 2019-11-19 Toshihiko Matsuura , Tatsuya Harada

Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem…

Machine Learning · Computer Science 2021-04-16 Haoran Zhang , Natalie Dullerud , Laleh Seyyed-Kalantari , Quaid Morris , Shalmali Joshi , Marzyeh Ghassemi

Domain generalization approaches aim to learn a domain invariant prediction model for unknown target domains from multiple training source domains with different distributions. Significant efforts have recently been committed to broad…

Computer Vision and Pattern Recognition · Computer Science 2021-08-23 Mohammad Mahfujur Rahman , Clinton Fookes , Sridha Sridharan

Population attributes are essential in health for understanding who the data represents and precision medicine efforts. Even within disease infection labels, patients can exhibit significant variability; "fever" may mean something different…

Machine Learning · Statistics 2018-11-28 Vishwali Mhasawade , Nabeel Abdur Rehman , Rumi Chunara

Deep learning models for clinical event prediction on electronic health records (EHR) often suffer performance degradation when deployed under different data distributions. While domain adaptation (DA) methods can mitigate such shifts, its…

Machine Learning · Computer Science 2026-02-16 Pengfei Hu , Chang Lu , Feifan Liu , Yue Ning

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Machine Learning · Computer Science 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Domain generalization involves learning a classifier from a heterogeneous collection of training sources such that it generalizes to data drawn from similar unknown target domains, with applications in large-scale learning and personalized…

Machine Learning · Computer Science 2021-12-24 Xavier Thomas , Dhruv Mahajan , Alex Pentland , Abhimanyu Dubey

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

The well known domain shift issue causes model performance to degrade when deployed to a new target domain with different statistics to training. Domain adaptation techniques alleviate this, but need some instances from the target domain to…

Machine Learning · Computer Science 2019-06-11 Yiying Li , Yongxin Yang , Wei Zhou , Timothy M. Hospedales

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Reiji Saito , Kazuhiro Hotta

The performance of predictive models in clinical settings often degrades when deployed in new hospitals due to distribution shifts. This paper presents a large-scale study of causality-inspired domain generalization on heterogeneous…

Applications · Statistics 2026-03-03 Malte Londschien , Manuel Burger , Gunnar Rätsch , Peter Bühlmann

Domain generalization (DG) aims to help models trained on a set of source domains generalize better on unseen target domains. The performances of current DG methods largely rely on sufficient labeled data, which are usually costly or…

Computer Vision and Pattern Recognition · Computer Science 2022-04-13 Xingxuan Zhang , Linjun Zhou , Renzhe Xu , Peng Cui , Zheyan Shen , Haoxin Liu

Deep learning based medical image diagnosis has shown great potential in clinical medicine. However, it often suffers two major difficulties in real-world applications: 1) only limited labels are available for model training, due to…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Yifan Zhang , Ying Wei , Qingyao Wu , Peilin Zhao , Shuaicheng Niu , Junzhou Huang , Mingkui Tan

Achieving domain generalization in medical imaging poses a significant challenge, primarily due to the limited availability of publicly labeled datasets in this domain. This limitation arises from concerns related to data privacy and the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Ahmed Radwan , Islam Osman , Mohamed S. Shehata

The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Mauricio Orbes-Arteaga , Thomas Varsavsky , Lauge Sorensen , Mads Nielsen , Akshay Pai , Sebastien Ourselin , Marc Modat , M Jorge Cardoso

Domain generalization(DG) endeavors to develop robust models that possess strong generalizability while preserving excellent discriminability. Nonetheless, pivotal DG techniques tend to improve the feature generalizability by learning…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Shaocong Long , Qianyu Zhou , Chenhao Ying , Lizhuang Ma , Yuan Luo

Deep neural networks (DNN) have demonstrated unprecedented success for medical imaging applications. However, due to the issue of limited dataset availability and the strict legal and ethical requirements for patient privacy protection, the…

Machine Learning · Computer Science 2023-09-19 Chris Xing Tian , Haoliang Li , Yufei Wang , Shiqi Wang

The generalization of deep neural networks to unknown domains is a major challenge despite their tremendous progress in recent years. For this reason, the dynamic area of domain generalization (DG) has emerged. In contrast to unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Manuel Schwonberg , Hanno Gottschalk
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