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Deterministic lateral displacement (DLD) is a popular technique for size-based separation of particles. One of the challenges in design of DLD chips is to eliminate the disturbance of fluid flow patterns caused by channel sidewalls…
In conventional Deterministic Lateral Displacement (DLD), the migration behavior of a particle of specific size is determined by the critical diameter (Dc), which is predefined by the device's geometry. In contrast to the typical approach…
Size-based separation of bioparticles/cells is crucial to a variety of biomedical processing steps for applications such as exosomes and DNA isolation. Design and improvement of such microfluidic devices is a challenge to best answer the…
Deterministic lateral displacement (DLD) devices separate micrometer-scale particles in solution based on their size using a laminar microfluidic flow in an array of obstacles. We investigate array geometries with rational row-shift…
Deterministic Lateral Displacement (DLD) devices enable liquid biopsy for cancer detection by separating circulating tumor cells (CTCs) from blood samples based on size, but designing these microfluidic devices requires computationally…
The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based…
We solve a design optimization problem for deterministic lateral displacement (DLD) device to sort same-size biological cells by their deformability, in particular to sort red blood cells (RBCs) by their viscosity contrast between the fluid…
We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…
We use a macromodel of a flow-driven deterministic lateral displacement (DLD) microfluidic system to investigate conditions leading to size-separation of suspended particles. This model system can be easily reconfigured to establish an…
We present a simple solution to enhance the separation ability of deterministic lateral displacement (DLD) systems by expanding the two-dimensional nature of these devices and driving the particles into size-dependent, fully…
In this paper, we describe the unification and extension of multiple kinematic theories on the advection of colloidal particles through periodic obstacle lattices of arbitrary geometry and infinitesimally small obstacle size. We focus…
Sorting cells based on their mechanical properties is essential for applications in disease diagnostics, cell therapy, and biomedical research. Deterministic Lateral Displacement (DLD) devices provide a label-free method for achieving such…
An electrokinetically-driven deterministic lateral displacement (e-DLD) device is proposed for the continuous, two-dimensional fractionation of suspensions in microfluidic platforms. The suspended species are driven through an array of…
Dissipative Particle Dynamics (DPD) is becoming a popular particle based method to study flow through microchannels due to the ease with which the presence of biological cells or DNA chains can be modeled. Many Lab-On-Chip (LOC) devices…
Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer…
An important step in diagnostics is the isolation of specific cells and microorganisms of interest from blood. Since such bioparticles are often present at very low concentrations, throughput needs to be as high as possible. In addition, to…
The control of particle trajectories in structured microfluidic environments has significantly advanced sorting technologies, most notably through deterministic lateral displacement (DLD). While previous work has largely targeted rigid,…
We uncover anisotropic permeability in microfluidic deterministic lateral displacement (DLD) arrays. A DLD array can achieve high-resolution bimodal size-based separation of microparticles, including bioparticles, such as cells. For an…
We analyze the trajectory of suspended spherical particles moving through a square array of obstacles, in the deterministic limit and at zero Reynolds number. We show that, in the dilute approximation of widely separated obstacles, the…
We propose a deterministic method to design irregular Low-Density Parity-Check (LDPC) codes for binary erasure channels (BEC). Compared to the existing methods, which are based on the application of asymptomatic analysis tools such as…