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Related papers: An analytical model for gold nanoparticle radiosen…

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Precise radiation delivery is critical for effective radiotherapy, and gold nanoparticles (AuNPs) have emerged as promising tools to enhance local dose deposition while sparing the surrounding healthy tissue. In this study, the PENELOPE…

When irradiation is performed with gold nanoparticles (AuNPs), a different shape of cells in suspension or adherent to walls may result in different probability of cell survival. In a recent study, differences of up to a factor of 2 were…

Medical Physics · Physics 2025-12-04 Hans Rabus , Oswald Msosa Mkanda

This work investigates the change in cell survival predicted by the local effect model (LEM) for an irradiated cell containing metal nanoparticles (MNPs) depending on the distribution of neighboring cells and the uptake of MNPs into the…

Medical Physics · Physics 2025-10-20 Hans Rabus , Leo Thomas

In radiobiological experiments, the cells can either float in suspension or adhere to the walls of the sample holder. When irradiation is performed in the presence of dose modifying agents such as gold nanoparticles (AuNPs), the different…

Medical Physics · Physics 2025-12-04 Hans Rabus , Oswald Msosa Mkanda

This work explores the enhancement of ionization clusters around a gold nanoparticle (NP), indicative of the induction of DNA lesions, a potential trigger for cell-death. Monte Carlo track structure simulations were performed to determine…

Medical Physics · Physics 2024-03-08 Leo Thomas , Miriam Schwarze , Hans Rabus

This study investigates the dynamic control of third-order nonlinear optical absorption properties of gold nanoparticles (AuNPs) dispersed in nematic liquid crystals (LC). By leveraging the reconfigurable nature of liquid crystals under…

Soft Condensed Matter · Physics 2025-02-17 Shengwei Wang , Mohamed Amine Gharbi , Chandra S Yelleswarapu

Purpose: The introduction of Gold NanoParticles (GNPs) in radiotherapy requires consideration of GNP size, location, and quantity, and more, as well as beam quality. The work is presented in two parts, with Part I (this work) investigating…

Medical Physics · Physics 2023-05-04 Martin P. Martinov , Elizabeth M. Fletcher , Rowan M. Thomson

Purpose: A novel approach using nano technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies…

Medical Physics · Physics 2012-06-25 F. Van den Heuvel , J. P. Locquet , S. Nuyts

Functionalized metal nanoparticles (NPs) have been proposed as promising radiosensitizing agents for more efficient radiotherapy treatment using photons and ion beams. Radiosensitizing properties of NPs may depend on many different…

Atomic and Molecular Clusters · Physics 2023-09-06 Alexey V. Verkhovtsev , Adam Nichols , Nigel J. Mason , Andrey V. Solov'yov

This study aimed to investigate the antitumor effect of ultrasmall gold nanoparticles (AuNPs), around 3 nm, stabilized by the anionic polysaccharide gum arabic (GA-AuNPs). The focus was downregulation of cancer hallmarks of aggressive…

We investigate plasmon resonances in gold nanoparticles to enhance the quantum yield of upconverting materials. For this purpose, we use a rate equation model that describes the upconversion of trivalent erbium based upconverters. Changes…

In their article published in Phys. Med. Biol. 60 (2015) 4149-4168, Lin et al studied the radiosensitizing effect of gold nanoparticles (GNPs) using radiation transport simulations and a biological model for the survival of irradiated…

Medical Physics · Physics 2023-02-13 Hans Rabus

Correlative light electron microscopy (CLEM) requires the availability of robust probes which are visible both in light and electron microscopy. Here we demonstrate a CLEM approach using small gold nanoparticles as a single probe.…

This study presents the results of atomistic structural characterisation of 3.7 nm diameter gold nanoparticles (NP) coated with polymer polyethylene glycol (PEG)-based ligands of different lengths (containing $2-14$ monomers) and solvated…

Atomic and Molecular Clusters · Physics 2023-09-07 Matthew D. Dickers , Alexey V. Verkhovtsev , Nigel J. Mason , Andrey V. Solov'yov

We report here a quantitative method of Transmission Electron Microscopy (TEM) to measure the shapes, sizes and volumes of nanoparticles which are responsible for their properties. Gold nanoparticles (Au NPs) acting as nucleating agents for…

There is considerable interest in the use of heavy atom nanoparticles as theranostic contrast agents due to their high radiation cross-section compared to soft tissue. However, published studies have primarily focused on applications of…

Medical Physics · Physics 2016-01-20 Stephen J. McMahon , Harald Paganetti , Kevin M. Prise

In this study, various nanoparticle species-including Au and Gd$_2$O$_3$-were irradiated with low-energy gamma rays, such as 59.5 keV photons from $^{241}$Am. Pulse-height spectra were recorded using a liquid-scintillation counting system…

Medical Physics · Physics 2025-08-21 Darukesha B H M

We simulate the localized surface plasmon resonances of an Au nanoparticle within tunneling proximity of a Au substrate and demonstrate that the modes may be identified with those responsible for light emission from a scanning tunneling…

Mesoscale and Nanoscale Physics · Physics 2012-07-18 J. Mitra , Lei Feng , Michael G. Boyle , P. Dawson

We systematically investigated and quantified how gold (Au) metal nanoparticles (NPs) optical spectra change upon introduction into biological tissue phantoms environment, in which the AuNPs can agglomerate. Quantitative knowledge of how…

Applied Physics · Physics 2021-03-17 J. C. R. Araujo , A. F. G. Monte , R. L. Serrano , W. Iwamoto , A. Antunes , O. Brener , M. Foschini

Versatile quantum modes emerge for plasmon describing the collective oscillations of free electrons in metallic nanoparticles when the particle sizes are greatly reduced. Rather than traditional nanoscale study, the understanding of quantum…

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