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A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital twins for disease processes, we can perform in-silico…

Machine Learning · Computer Science 2024-11-04 Keying Kuang , Frances Dean , Jack B. Jedlicki , David Ouyang , Anthony Philippakis , David Sontag , Ahmed M. Alaa

One of the challenges in twinned systems is ensuring the digital twin remains a valid representation of the system it twins. Depending on the type of twinning occurring, it is either trivial, such as in dashboarding/visualizations that…

Software Engineering · Computer Science 2025-12-05 Joost Mertens , Joachim Denil

Digital Twin (DT) has gained great interest as an innovative technology in Industry 4.0 that enables advanced modeling, simulation, and optimization of service and manufacturing systems. This article provides an extensive review of the…

General Mathematics · Mathematics 2026-01-26 Sarow Saeedi

With rapid digitization and digitalization, drawing a fine line between the digital and the physical world has become nearly impossible. It has become essential more than ever to integrate all spheres of life into a single Digital Thread to…

Since the introduction of Industry 4.0, digital twin technology has significantly evolved, laying the groundwork for a transition toward Industry 5.0 principles centered on human-centricity, sustainability, and resilience. Through digital…

Digital Twins (DTs) are virtual representations of physical systems synchronized in real time through Internet of Things (IoT) sensors and computational models. In industrial applications, DTs enable predictive maintenance, fault diagnosis,…

Other Computer Science · Computer Science 2025-07-18 Ali Mohammad-Djafari

Digital twins (DT) of industrial processes have become increasingly important. They aim to digitally represent the physical world to help evaluate, optimize, and predict physical processes and behaviors. Therefore, DT is a vital tool to…

Software Engineering · Computer Science 2023-02-28 Yunpeng Ma , Khalil Younis , Bestoun S. Ahmed , Andreas Kassler , Pavel Krakhmalev , Andreas Thore , Hans Lindback

Developing embodied AI for intelligent surgical systems requires safe, controllable environments for continual learning and evaluation. However, safety regulations and operational constraints in operating rooms (ORs) limit agents from…

As the manufacturing industry shifts from mass production to mass customization, there is a growing emphasis on adopting agile, resilient, and human-centric methodologies in line with the directives of Industry 5.0. Central to this…

Digital twin, which enables emulation, evaluation, and optimization of physical entities through synchronized digital replicas, has gained increasing attention as a promising technology for intricate wireless networks. For 6G, numerous…

Networking and Internet Architecture · Computer Science 2024-08-12 Zhenyu Tao , Wei Xu , Yongming Huang , Xiaoyun Wang , Xiaohu You

Digital twins are transforming engineering and applied sciences by enabling real-time monitoring, simulation, and predictive analysis of physical systems and processes. However, conventional digital twins rely primarily on passive data…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Matteo Torzoni , Domenico Maisto , Andrea Manzoni , Francesco Donnarumma , Giovanni Pezzulo , Alberto Corigliano

Animal behavior reflects interactions between the nervous system, body, and environment. Therefore, biomechanics and environmental context must be considered to understand algorithms for behavioral control. Neuromechanical digital twins,…

Neurons and Cognition · Quantitative Biology 2026-04-14 Sibo Wang-Chen , Pavan Ramdya

Digital Twin has emerged as a promising paradigm for accurately representing wireless communication electromagnetic environments. The resulting virtual representation of reality facilitates comprehensive insights into the propagation…

Signal Processing · Electrical Eng. & Systems 2024-10-03 Michele Zhu , Lorenzo Cazzella , Francesco Linsalata , Maurizio Magarini , Matteo Matteucci , Umberto Spagnolini

The design and operation of systems are conventionally viewed as a sequential decision-making process that is informed by data from physical experiments and simulations. However, the integration of these high-dimensional and heterogeneous…

Applications · Statistics 2025-03-04 Anton van Beek , Vispi Karkaria , Wei Chen

As a pivotal virtualization technology, network digital twin is expected to accurately reflect real-time status and abstract features in the on-going sixth generation (6G) networks. In this article, we propose an artificial intelligence…

Networking and Internet Architecture · Computer Science 2024-10-10 Wen Wu , Xinyu Huang , Tom H. Luan

As a bridge from virtuality to reality, Digital Twin has increased in popularity since proposed. Ideas have been proposed theoretical and practical for digital twins. From theoretical perspective, digital twin is fusion of data mapping…

Computers and Society · Computer Science 2024-03-27 Lu Jingyu

Digital Twin is an emerging technology at the forefront of Industry 4.0, with the ultimate goal of combining the physical space and the virtual space. To date, the Digital Twin concept has been applied in many engineering fields, providing…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Alex To , Maican Liu , Muhammad Hazeeq Bin Muhammad Hairul , Joseph G. Davis , Jeannie S. A. Lee , Henrik Hesse , Hoang D. Nguyen

Digital Twins combine simulation, operational data and Artificial Intelligence (AI), and have the potential to bring significant benefits across the aviation industry. Project Bluebird, an industry-academic collaboration, has developed a…

Artificial Intelligence · Computer Science 2026-01-07 Adam Keane , Nick Pepper , Chris Burr , Amy Hodgkin , Dewi Gould , John Korna , Marc Thomas

Simulation frameworks have been key enablers for the development and validation of autonomous driving systems. However, existing methods struggle to comprehensively address the autonomy-oriented requirements of balancing: (i) dynamical…

Robotics · Computer Science 2026-02-23 Tanmay Vilas Samak , Chinmay Vilas Samak , Bing Li , Venkat Krovi

The adoption of Digital Twin technologies is rapidly expanding in diverse industrial, economic, and societal domains. Over the past decade, a multitude of studies, surveys, and investigations have been conducted, examining the nature,…

Software Engineering · Computer Science 2026-03-09 Philipp Zech , Yanis Mair , Michael Vierhauser , Pablo Oliveira Antonino , Frank Schnicke , Tony Clark