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Accurate lesion segmentation in whole-body PET/CT scans is crucial for cancer diagnosis and treatment planning, but limited datasets often hinder the performance of automated segmentation models. In this paper, we explore the potential of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Lap Yan Lennon Chan , Chenxin Li , Yixuan Yuan

Despite the promise of computational pathology foundation models, adapting them to specific clinical tasks remains challenging due to the complexity of whole-slide image (WSI) processing, the opacity of learned features, and the wide range…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdul Rahman Diab , Emily E. Karn , Renchin Wu , Emily S. Ruiz , William Lotter

In the field of deep learning, large architectures often obtain the best performance for many tasks, but also require massive datasets. In the histological domain, tissue images are expensive to obtain and constitute sensitive medical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Andrei-Alexandru Preda , Iulian-Marius Tăiatu , Dumitru-Clementin Cercel

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Advancements in diffusion-based foundation models have improved text-to-image generation, yet most efforts have been limited to low-resolution settings. As high-resolution image synthesis becomes increasingly essential for various…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Zahra TehraniNasab , Amar Kumar , Tal Arbel

Generative Adversarial Networks (GANs) are the driving force behind the state-of-the-art in image generation. Despite their ability to synthesize high-resolution photo-realistic images, generating content with on-demand conditioning of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Markos Georgopoulos , James Oldfield , Grigorios G Chrysos , Yannis Panagakis

Learning high-quality, self-supervised, visual representations is essential to advance the role of computer vision in biomedical microscopy and clinical medicine. Previous work has focused on self-supervised representation learning (SSL)…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Cheng Jiang , Xinhai Hou , Akhil Kondepudi , Asadur Chowdury , Christian W. Freudiger , Daniel A. Orringer , Honglak Lee , Todd C. Hollon

Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Jingsong Liu , Xiaofeng Deng , Han Li , Azar Kazemi , Christian Grashei , Gesa Wilkens , Xin You , Tanja Groll , Nassir Navab , Carolin Mogler , Peter J. Schüffler

Generating synthetic datasets for training face recognition models is challenging because dataset generation entails more than creating high fidelity images. It involves generating multiple images of same subjects under different factors…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Minchul Kim , Feng Liu , Anil Jain , Xiaoming Liu

Early diagnosis of the cancer cells is necessary for making an effective treatment plan and for the health and safety of a patient. Nowadays, doctors usually use a histological grade that pathologists determine by performing a…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Varan Singh Rohila , Neeraj Lalwani , Lochan Basyal

The diagnosis of cancer is mainly performed by visual analysis of the pathologists, through examining the morphology of the tissue slices and the spatial arrangement of the cells. If the microscopic image of a specimen is not stained, it…

Image and Video Processing · Electrical Eng. & Systems 2020-02-06 Pegah Salehi , Abdolah Chalechale

Multi-modal foundation models are typically trained on millions of pairs of natural images and text captions, frequently obtained through web-crawling approaches. Although such models depict excellent generative capabilities, they do not…

Computer Vision and Pattern Recognition · Computer Science 2023-01-03 Pierre Chambon , Christian Bluethgen , Curtis P. Langlotz , Akshay Chaudhari

Counterfactual medical image generation effectively addresses data scarcity and enhances the interpretability of medical images. However, due to the complex and diverse pathological features of medical images and the imbalanced class…

Computer Vision and Pattern Recognition · Computer Science 2025-04-25 Weizhi Nie , Zichun Zhang , Weijie Wang , Bruno Lepri , Anan Liu , Nicu Sebe

Long-tailed class distributions are pervasive in multi-class medical datasets and pose significant challenges for deep learning models which typically underperform on tail classes with limited samples. This limitation is particularly…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Jiaxiang Jiang , Mahesh Subedar , Omesh Tickoo

In this paper, we present our approach to the DataCV ICCV Challenge, which centers on building a high-quality face dataset to train a face recognition model. The constructed dataset must not contain identities overlapping with any existing…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Feiran Li , Qianqian Xu , Shilong Bao , Boyu Han , Zhiyong Yang , Qingming Huang

Semantic segmentation of breast cancer metastases in histopathological slides is a challenging task. In fact, significant variation in data characteristics of histopathology images (domain shift) make generalization of deep learning to…

Image and Video Processing · Electrical Eng. & Systems 2021-06-01 Gianluca Gerard , Marco Piastra

Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Niccoló Marini , Manfredo Atzori , Sebastian Otálora , Stephane Marchand-Maillet , Henning Müller

Pretraining on large-scale, in-domain datasets grants histopathology foundation models (FM) the ability to learn task-agnostic data representations, enhancing transfer learning on downstream tasks. In computational pathology, automated…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Pablo Meseguer , Rocío del Amor , Valery Naranjo

Batch effects arising from technical variations in histopathology staining protocols, scanners, and acquisition pipelines pose a persistent challenge for computational pathology, hindering cross-batch generalization and limiting reliable…

Machine Learning · Computer Science 2026-03-02 Xiaolong Zhang , Jianwei Zhang , Selim Sevim , Emek Demir , Ece Eksi , Xubo Song

For invasive breast cancer, immunohistochemical (IHC) techniques are often used to detect the expression level of human epidermal growth factor receptor-2 (HER2) in breast tissue to formulate a precise treatment plan. From the perspective…