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Incremental SAT and QBF solving potentially yields improvements when sequences of related formulas are solved. An incremental application is usually tailored towards some specific solver and decomposes a problem into incremental solver…

Logic in Computer Science · Computer Science 2015-12-04 Uwe Egly , Florian Lonsing , Johannes Oetsch

A range of quantum algorithms, especially those leveraging variational parameterization and circuit-based optimization, are being studied as alternatives for solving classically intractable combinatorial optimization problems (COPs).…

Quantum Physics · Physics 2025-06-18 Monit Sharma , Hoong Chuin Lau

Quantitative Systems Pharmacology (QSP) promises to accelerate drug development, enable personalized medicine, and improve the predictability of clinical outcomes. Realizing this potential requires effectively managing the complexity of…

Quantitative Methods · Quantitative Biology 2025-06-10 Noah DeTal , Christian N. K. Anderson , Mark K. Transtrum

Quantum machine learning is a promising field for efficiently learning features of a dataset to perform a specified task, such as classification. Interval bound propagation (IBP) is a popular certified training method in classical machine…

Quantum Physics · Physics 2026-05-04 Emma Andrews , Nahyeon Kim , Prabhat Mishra

Integer Quadratic Programming (IQP), $\min\{x^T Q x + c^T x : Ax \le b,\, x\in\Z^n\}$, is a fundamental problem in combinatorial optimization. While the convex and concave special cases admit polynomial-time algorithms for fixed~$n$, the…

Optimization and Control · Mathematics 2026-04-07 Cinar Ari , Robert Hildebrand

Missing data presents a critical challenge in real-world datasets, significantly degrading the performance of machine learning models. While Large Language Models (LLMs) have recently demonstrated remarkable capabilities in tabular data…

Machine Learning · Computer Science 2025-07-14 Hossein Jamali

Constraint programming (CP) is a paradigm used to model and solve constraint satisfaction and combinatorial optimization problems. In CP, problems are modeled with constraints that describe acceptable solutions and solved with backtracking…

Quantum Physics · Physics 2021-09-29 Kyle E. C. Booth , Bryan O'Gorman , Jeffrey Marshall , Stuart Hadfield , Eleanor Rieffel

This paper presents a new hybrid classical-quantum approach to solve Mixed Integer Linear Programming (MILP) using neutral atom quantum computations. We apply Benders decomposition (BD) to segment MILPs into a master problem (MP) and a…

Quantum Physics · Physics 2024-07-17 M. Yassine Naghmouchi , Wesley da Silva Coelho

Layer-wise PTQ is a promising technique for compressing large language models (LLMs), due to its simplicity and effectiveness without requiring retraining. However, recent progress in this area is saturating, underscoring the need to…

Machine Learning · Computer Science 2026-01-14 Yamato Arai , Yuma Ichikawa

The quantified Boolean formula (QBF) problem is an important decision problem generally viewed as the archetype for PSPACE-completeness. Many problems of central interest in AI are in general not included in NP, e.g., planning, model…

Computational Complexity · Computer Science 2024-05-13 Leif Eriksson , Victor Lagerkvist , George Osipov , Sebastian Ordyniak , Fahad Panolan , Mateusz Rychlicki

Mixed-integer linear programming (MILP) plays a crucial role in artificial intelligence, biochemistry, finance, cryptography, etc. Notwithstanding popular for decades, the researches of MILP solvers are still limited by the resource…

Quantum Physics · Physics 2022-04-12 Hao Wang , Yu Pan , Wei Cui

Quantum interior point methods (QIPMs) promise polynomial speed-ups over classical solvers for linear programming by outsourcing the solution of Newton linear systems to quantum linear solvers (QLSAs). However, asymptotic speed-ups do not…

Quantum Physics · Physics 2026-04-28 Lennart Binkowski

In this work, we introduce a novel Quadratic Binary Optimization (QBO) framework for training a quantized neural network. The framework enables the use of arbitrary activation and loss functions through spline interpolation, while Forward…

Machine Learning · Computer Science 2025-12-09 Wenxin Li , Chuan Wang , Hongdong Zhu , Qi Gao , Yin Ma , Hai Wei , Kai Wen

Answer Set Programming with Quantifiers (ASP(Q)) has been introduced to provide a natural extension of ASP modeling to problems in the polynomial hierarchy (PH). However, ASP(Q) lacks a method for encoding in an elegant and compact way…

Artificial Intelligence · Computer Science 2025-01-22 Giuseppe Mazzotta , Francesco Ricca , Mirek Truszczynski

Quadratically Constrained Quadratic Programs (QCQPs) are an important class of optimization problems with diverse real-world applications. In this work, we propose a variational quantum algorithm for general QCQPs. By encoding the variables…

Quantum Physics · Physics 2023-09-20 Hongyi Zhou , Sirui Peng , Qian Li , Xiaoming Sun

Machine Learning (ML) optimization frameworks have gained attention for their ability to accelerate the optimization of large-scale Quadratically Constrained Quadratic Programs (QCQPs) by learning shared problem structures. However,…

Optimization and Control · Mathematics 2024-10-08 Zhixiao Xiong , Fangyu Zong , Huigen Ye , Hua Xu

Iterative Refinement (IR) is a classical computing technique for obtaining highly precise solutions to linear systems of equations, as well as linear optimization problems. In this paper, motivated by the limited precision of quantum…

Optimization and Control · Mathematics 2023-12-19 Mohammadhossein Mohammadisiahroudi , Brandon Augustino , Pouya Sampourmahani , Tamás Terlaky

We study the problem of training and certifying adversarially robust quantized neural networks (QNNs). Quantization is a technique for making neural networks more efficient by running them using low-bit integer arithmetic and is therefore…

Machine Learning · Computer Science 2022-11-30 Mathias Lechner , Đorđe Žikelić , Krishnendu Chatterjee , Thomas A. Henzinger , Daniela Rus

The selection of branching variables is a key component of branch-and-bound algorithms for solving Mixed-Integer Programming (MIP) problems since the quality of the selection procedure is likely to have a significant effect on the size of…

Optimization and Control · Mathematics 2016-08-23 Pierre Le Bodic , George L. Nemhauser

We consider a discrete optimization formulation for learning sparse classifiers, where the outcome depends upon a linear combination of a small subset of features. Recent work has shown that mixed integer programming (MIP) can be used to…

Machine Learning · Statistics 2021-06-08 Antoine Dedieu , Hussein Hazimeh , Rahul Mazumder