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Introduction: Feature selection and gene set analysis are of increasing interest in bioinformatics. While these two approaches have been developed for different purposes, we describe how some gene set analysis methods can be used to conduct…

Methodology · Statistics 2015-11-30 Suyan Tian , Chi Wang , Howard H. Chang

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

Artificial Intelligence · Computer Science 2025-02-24 Brian Hyeongseok Kim , Chao Wang

The prediction of chemical synthesis pathways plays a pivotal role in materials science research. Challenges, such as the complexity of synthesis pathways and the lack of comprehensive datasets, currently hinder our ability to predict these…

Materials Science · Physics 2023-11-03 Ziyi Chen , Fankai Xie , Meng Wan , Yang Yuan , Miao Liu , Zongguo Wang , Sheng Meng , Yangang Wang

Retrieval-augmented Generation (RAG) extends large language models (LLMs) with external knowledge but faces key challenges: restricted effective context length and redundancy in retrieved documents. Pure compression-based approaches reduce…

Computation and Language · Computer Science 2025-07-09 Yiqiao Jin , Kartik Sharma , Vineeth Rakesh , Yingtong Dou , Menghai Pan , Mahashweta Das , Srijan Kumar

The interpretation of human voices holds importance across various applications. This study ventures into predicting age, gender, and emotion from vocal cues, a field with vast applications. Voice analysis tech advancements span domains,…

Audio and Speech Processing · Electrical Eng. & Systems 2024-03-05 Aron R , Indra Sigicharla , Chirag Periwal , Mohanaprasad K , Nithya Darisini P S , Sourabh Tiwari , Shivani Arora

Generative models are a class of AI models capable of creating new instances of data by learning and sampling from their statistical distributions. In recent years, these models have gained prominence in machine learning due to the…

Facial analysis technologies have recently measured up to the capabilities of expert clinicians in syndrome identification. To date, these technologies could only identify phenotypes of a few diseases, limiting their role in clinical…

Computer Vision and Pattern Recognition · Computer Science 2018-01-24 Yaron Gurovich , Yair Hanani , Omri Bar , Nicole Fleischer , Dekel Gelbman , Lina Basel-Salmon , Peter Krawitz , Susanne B Kamphausen , Martin Zenker , Lynne M. Bird , Karen W. Gripp

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable…

Machine Learning · Computer Science 2023-01-20 Pulakesh Upadhyaya , Kai Zhang , Can Li , Xiaoqian Jiang , Yejin Kim

Sentence semantic matching requires an agent to determine the semantic relation between two sentences, where much recent progress has been made by the advancement of representation learning techniques and inspiration of human behaviors.…

Computation and Language · Computer Science 2021-06-10 Kun Zhang , Guangyi Lv , Meng Wang , Enhong Chen

Unobserved confounding is common in many applications, making causal inference from observational data challenging. As a remedy, causal sensitivity analysis is an important tool to draw causal conclusions under unobserved confounding with…

Machine Learning · Computer Science 2024-04-10 Dennis Frauen , Fergus Imrie , Alicia Curth , Valentyn Melnychuk , Stefan Feuerriegel , Mihaela van der Schaar

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker…

Methodology · Statistics 2025-11-13 Anthony-Alexander Christidis , Stefan Van Aelst , Ruben Zamar

Semantic segmentation has made significant strides in pixel-level image understanding, yet it remains limited in capturing contextual and semantic relationships between objects. Current models, such as CNN and Transformer-based…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Ben Rahman

Computational analysis methods including machine learning have a significant impact in the fields of genomics and medicine. High-throughput gene expression analysis methods such as microarray technology and RNA sequencing produce enormous…

Genomics · Quantitative Biology 2022-09-28 Nikita Bhandari , Rahee Walambe , Ketan Kotecha , Satyajeet Khare

Structured data, such as tables, graphs, and databases, play a critical role in plentiful NLP tasks such as question answering and dialogue system. Recently, inspired by Vision-Language Models, Graph Neutral Networks (GNNs) have been…

Computation and Language · Computer Science 2025-02-11 Yao Xu , Shizhu He , Jiabei Chen , Zeng Xiangrong , Bingning Wang , Guang Liu , Jun Zhao , Kang Liu

GA LLM is a hybrid framework that combines Genetic Algorithms with Large Language Models to handle structured generation tasks under strict constraints. Each output, such as a plan or report, is treated as a gene, and evolutionary…

Computation and Language · Computer Science 2025-06-17 William Shum , Rachel Chan , Jonas Lin , Benny Feng , Patrick Lau

Gene expression profiles obtained through DNA microarray have proven successful in providing critical information for cancer detection classifiers. However, the limited number of samples in these datasets poses a challenge to employ complex…

Machine Learning · Computer Science 2024-08-20 Arya Hadizadeh Moghaddam , Mohsen Nayebi Kerdabadi , Cuncong Zhong , Zijun Yao

Speech, language, and communication deficits are present in most neurodegenerative syndromes. They enable the early detection, diagnosis, treatment planning, and monitoring of neurocognitive disease progression as part of traditional…

Computation and Language · Computer Science 2023-12-07 Charalambos Themistocleous , Kyrana Tsapkini , Dimitrios Kokkinakis

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Interpreting RNA-sequencing data requires identifying coordinated gene expression patterns that correspond to biological pathways. Standard factor models provide useful dimension reduction but typically ignore existing pathway knowledge or…

Methodology · Statistics 2026-03-25 Lorenzo Mauri , Federica Stolf , Amy H. Herring , Cameron Miller , David B. Dunson

Recently, several studies have explored methods for using KG embedding to answer logical queries. These approaches either treat embedding learning and query answering as two separated learning tasks, or fail to deal with the variability of…

Machine Learning · Computer Science 2019-10-02 Gengchen Mai , Krzysztof Janowicz , Bo Yan , Rui Zhu , Ling Cai , Ni Lao